FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281489076> ?p ?o ?g. }

• W4281489076 endingPage "285" @default.
• W4281489076 startingPage "277" @default.
• W4281489076 abstract "Non-small cell lung cancer (NSCLC) occupies the first place in the structure of mortality due to oncological diseases. Late diagnosis worsens the effectiveness of its treatment. There are no informative biomarkers that allow us to judge the prevalence of the tumor process, especially in the early stages of NSCLC. To determine the level of CXCL5, CXCL8, CXCR1 and CXCR2 in the peripheral blood of patients with NSCLC to assess the possibility of their use in the diagnosis of the disease. The material was the blood of 218 patients with NSCLC, 19 patients with lung hamartoma and 42 healthy people. The concentration of CXCL5, CXCL8, and SCC in blood serum was determined by enzyme immunoassay, the CYFRA 21-1 level was determined by immunochemiluminescence analysis. The proportion of leukocytes equipped with CXCR1 and CXCR2 receptors and the fluorescence intensity of receptor complexes with antibodies (MFI) in them were measured by flow cytometry. MFI CXCR1 in granulocytes and the proportion of lymphocytes supplied CXCR2, increased in the blood already at stage I of NSCLC and showed an even more significant increase in subsequent stages. The level of these indicators was correlatively related to the stages and characteristics of NSCLC. Measuring the level of MFI CXCR1 in the blood serum makes it possible to diagnose the early stages of NSCLC with a sensitivity of 87.4% (specificity - 73.8%). Determination of the proportion of lymphocytes equipped with CXCR2 demonstrates comparable diagnostic sensitivity (87.2%) and specificity of 66.7% in the detection of stages I-II of NSCLC. MFI CXCR1 in granulocytes can also be used to differentiate stages I and II of NSCLC (diagnostic sensitivity - 75,3%, specificity - 69,6%). The sensitivity of determining for this purpose the proportion of lymphocytes equipped with CXCR2 is 75.0% with a specificity of 71.7%. In 89.7% of patients with stages III-IV NSCLC, the MFI CXCR1 in granulocytes exceeds the threshold value of 47.8 (specificity - 74.8%). Diagnostic sensitivity of determining the proportion of lymphocytes for this purpose was 90.7%." @default.
• W4281489076 created "2022-05-26" @default.
• W4281489076 creator A5000329136 @default.
• W4281489076 creator A5002304828 @default.
• W4281489076 creator A5018364544 @default.
• W4281489076 creator A5078972262 @default.
• W4281489076 creator A5089715189 @default.
• W4281489076 date "2022-05-21" @default.
• W4281489076 modified "2023-10-16" @default.
• W4281489076 title "On the issue of diagnostic value of determining the level of receptors and their ligands in blood in non-small cell lung cancer" @default.
• W4281489076 cites W1992287102 @default.
• W4281489076 cites W1998833321 @default.
• W4281489076 cites W2011674399 @default.
• W4281489076 cites W2031162487 @default.
• W4281489076 cites W2056088187 @default.
• W4281489076 cites W2076115419 @default.
• W4281489076 cites W2093511814 @default.
• W4281489076 cites W2110620425 @default.
• W4281489076 cites W2111736738 @default.
• W4281489076 cites W2117499321 @default.
• W4281489076 cites W2145921423 @default.
• W4281489076 cites W2148538574 @default.
• W4281489076 cites W2149405617 @default.
• W4281489076 cites W2162954813 @default.
• W4281489076 cites W2515969222 @default.
• W4281489076 cites W2588498677 @default.
• W4281489076 cites W2611412386 @default.
• W4281489076 cites W2729152108 @default.
• W4281489076 cites W2754608002 @default.
• W4281489076 cites W2768730324 @default.
• W4281489076 cites W2805101554 @default.
• W4281489076 cites W2968510131 @default.
• W4281489076 cites W2969447204 @default.
• W4281489076 cites W3006998898 @default.
• W4281489076 cites W3020886383 @default.
• W4281489076 cites W3128646645 @default.
• W4281489076 cites W3202857239 @default.
• W4281489076 cites W3210461663 @default.
• W4281489076 doi "https://doi.org/10.51620/0869-2084-2022-67-5-277-285" @default.
• W4281489076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35613346" @default.
• W4281489076 hasPublicationYear "2022" @default.
• W4281489076 type Work @default.
• W4281489076 citedByCount "0" @default.
• W4281489076 crossrefType "journal-article" @default.
• W4281489076 hasAuthorship W4281489076A5000329136 @default.
• W4281489076 hasAuthorship W4281489076A5002304828 @default.
• W4281489076 hasAuthorship W4281489076A5018364544 @default.
• W4281489076 hasAuthorship W4281489076A5078972262 @default.
• W4281489076 hasAuthorship W4281489076A5089715189 @default.
• W4281489076 hasConcept C121608353 @default.
• W4281489076 hasConcept C126322002 @default.
• W4281489076 hasConcept C12823836 @default.
• W4281489076 hasConcept C13373296 @default.
• W4281489076 hasConcept C142724271 @default.
• W4281489076 hasConcept C143998085 @default.
• W4281489076 hasConcept C146357865 @default.
• W4281489076 hasConcept C151730666 @default.
• W4281489076 hasConcept C159654299 @default.
• W4281489076 hasConcept C170493617 @default.
• W4281489076 hasConcept C203014093 @default.
• W4281489076 hasConcept C2776256026 @default.
• W4281489076 hasConcept C2777714996 @default.
• W4281489076 hasConcept C2780420688 @default.
• W4281489076 hasConcept C553184892 @default.
• W4281489076 hasConcept C71924100 @default.
• W4281489076 hasConcept C7806222 @default.
• W4281489076 hasConcept C84913492 @default.
• W4281489076 hasConcept C86803240 @default.
• W4281489076 hasConcept C90924648 @default.
• W4281489076 hasConceptScore W4281489076C121608353 @default.
• W4281489076 hasConceptScore W4281489076C126322002 @default.
• W4281489076 hasConceptScore W4281489076C12823836 @default.
• W4281489076 hasConceptScore W4281489076C13373296 @default.
• W4281489076 hasConceptScore W4281489076C142724271 @default.
• W4281489076 hasConceptScore W4281489076C143998085 @default.
• W4281489076 hasConceptScore W4281489076C146357865 @default.
• W4281489076 hasConceptScore W4281489076C151730666 @default.
• W4281489076 hasConceptScore W4281489076C159654299 @default.
• W4281489076 hasConceptScore W4281489076C170493617 @default.
• W4281489076 hasConceptScore W4281489076C203014093 @default.
• W4281489076 hasConceptScore W4281489076C2776256026 @default.
• W4281489076 hasConceptScore W4281489076C2777714996 @default.
• W4281489076 hasConceptScore W4281489076C2780420688 @default.
• W4281489076 hasConceptScore W4281489076C553184892 @default.
• W4281489076 hasConceptScore W4281489076C71924100 @default.
• W4281489076 hasConceptScore W4281489076C7806222 @default.
• W4281489076 hasConceptScore W4281489076C84913492 @default.
• W4281489076 hasConceptScore W4281489076C86803240 @default.
• W4281489076 hasConceptScore W4281489076C90924648 @default.
• W4281489076 hasIssue "5" @default.
• W4281489076 hasLocation W42814890761 @default.
• W4281489076 hasLocation W42814890762 @default.
• W4281489076 hasOpenAccess W4281489076 @default.
• W4281489076 hasPrimaryLocation W42814890761 @default.
• W4281489076 hasRelatedWork W2020488282 @default.
• W4281489076 hasRelatedWork W2032912323 @default.
• W4281489076 hasRelatedWork W2044631954 @default.
• W4281489076 hasRelatedWork W2087332109 @default.

• next