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- W4281489734 abstract "Current treatment for chronic HBV infection is mainly based on nucleos(t)ide analogues, that in most cases need to be administered for a patient’s lifetime. There is therefore a pressing need to develop new therapeutic strategies to shorten antiviral treatments. A severe dysfunction of virus-specific T cell responses contributes to virus persistence; hence, immune-modulation to reconstitute an efficient host antiviral response is considered a potential approach for HBV cure. In this perspective, a detailed understanding of the different causes of T cell exhaustion is essential for the design of successful functional T cell correction strategies. Among many different mechanisms which are widely believed to play a role in T cell dysfunction, persistent T cell exposure to high antigen burden, in particular HBsAg, is expected to influence T cell differentiation and function. Definitive evidence of the possibility to improve anti-viral T cell functions by antigen decline is, however, still lacking. This review aims at recapitulating what we have learned so far on the complex T cell–viral antigen interplay in chronic HBV infection." @default.
- W4281489734 created "2022-05-26" @default.
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- W4281489734 date "2022-05-24" @default.
- W4281489734 modified "2023-10-16" @default.
- W4281489734 title "Antigen Load and T Cell Function: A Challenging Interaction in HBV Infection" @default.
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- W4281489734 doi "https://doi.org/10.3390/biomedicines10061224" @default.
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