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• W4281489781 abstract "In recent years, there has been a decrease in reproductive potential, especially among residents of the Arctic territories, having the greatest stress from various body systems, including the state of the hormonal regulation of the male reproductive system. The study of the dopamine levels and the content of sex hormones in the male population of various Arctic regions is relevant due to the increased stress on the part of the dopaminergic system and the hypothalamic-pituitary-gonadal axis in residents of the Northern regions, as well as the lack of information about their interaction among the apparently healthy population. The aim of the investigation is to study the possible effect of various plasma concentrations of the dopamine on the content of sex hormones and sex-steroid-binding β-globulin (SHBG) in apparently healthy men in the Arctic zone of the Russian Federation, taking into account the territory of residence. There were examined 181 men aged 22-60 years, living in the territories of the European and Asian North. The levels of sex hormones, SHBG, and dopamine were determined by the enzyme-linked immunosorbent assay. The inhabitants of the Asian North in comparison with the men of the European North have higher levels of dopamine, luteinizing hormone, progesterone, prolactin, estradiol and SHBG with decreased serum levels of free fractions of testosterone. Reference levels of dopamine in men from the European North are combined with the stimulatory effect of dopamine on LH levels, which may indicate an increase steroidogenesis. The high levels of dopamine in men from the Asian North are combined with increased level of estradiol, which may be related to the effect of dopamine on testosterone aromatization. The separate region with its ecological differences is characterized by the presence of features of compensatory-adaptive reactions of an organism in male representatives on the part of the dopaminergic system and the hypothalamic-pituitary-gonadal axis. The identified features can help in carrying out preventive measures aimed at preserving the male reproductive potential of the inhabitants of the Arctic territories." @default.
• W4281489781 created "2022-05-26" @default.
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• W4281489781 date "2022-05-21" @default.
• W4281489781 modified "2023-10-18" @default.
• W4281489781 title "Distinctive features of the hypothalamic-pituitary-gonadal axis and the level of dopamine in men of the European and Asian North" @default.
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• W4281489781 doi "https://doi.org/10.51620/0869-2084-2022-67-5-261-266" @default.
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