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• W4281491368 endingPage "103454" @default.
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• W4281491368 abstract "Protein/peptide aggregation-induced cell death is the culprit of many neurodegenerative diseases. Many peptide drugs were designed to inhibit protein/peptide aggregation. However, the brain penetration rate is a key issue in determining the efficacy of the peptide drugs in the brain. The nose-to-brain drug delivery is a potential administration route to bypass the blood-brain barrier and to avoid peptide degradation that possibly occurred in other administrative routes. Here, the temporal and spatial distribution of a radiolabeled anti-amyloid peptide, that could reduce the amyloid load and attenuate the cognitive decline in AD transgenic mice via intranasal administration, was examined by the SPECT/CT scan. The brain uptake rate was 0.73–1.78%ID/g tissue. The biological half-life of the peptide in the brain was 10.2 ± 0.8 h. The nose-to-brain penetration efficiency and the whole-body biodistribution of an anti-Aβ peptide drug via intranasal administration was measured by the in vivo SPECT/CT imaging. • The nose-to-brain delivery of an anti-amyloid peptide drug is monitored by the SPECT/CT imaging. • The biological half-life of the peptide in the brain is 10.2 ± 0.8 h. • The nose-to-brain uptake rate is 0.73–1.78%ID/g tissue at 0.5 h post-administration." @default.
• W4281491368 created "2022-05-26" @default.
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• W4281491368 date "2022-07-01" @default.
• W4281491368 modified "2023-09-29" @default.
• W4281491368 title "Biodistribution analysis of an intranasal-delivered peptide by the nanoSPECT/CT imaging" @default.
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• W4281491368 doi "https://doi.org/10.1016/j.jddst.2022.103454" @default.
• W4281491368 hasPublicationYear "2022" @default.
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