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- W4281492015 abstract "Potential noninvasive biomarkers and immune cell populations may help predict histological activity versus quiescence in patients with autoimmune hepatitis. Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment consists of systemic corticosteroids, or budesonide, and azathioprine, to which most patients are initially responsive, although predictors of response are lacking. Relapses are very common, correlate with histological activity despite normal serum transaminases, and increase hepatic fibrosis. Furthermore, current regimens lead to adverse effects and reduced quality of life, whereas medication titration is imprecise. Biomarkers that can predict the clinical course of disease, identify patients at elevated risk for relapse, and improve monitoring and medication dosing beyond current practice would have high clinical value. Herein, we review novel candidate biomarkers in adult and pediatric AIH based on prespecified criteria, including gene expression profiles, proteins, metabolites, and immune cell phenotypes in different stages of AIH. We also discuss biomarkers relevant to AIH from other immune diseases. We conclude with proposed future directions in which biomarker implementation into clinical practice could lead to advances in personalized therapeutic management of AIH." @default.
- W4281492015 created "2022-05-26" @default.
- W4281492015 creator A5005075162 @default.
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- W4281492015 creator A5070688586 @default.
- W4281492015 creator A5084160097 @default.
- W4281492015 date "2022-06-08" @default.
- W4281492015 modified "2023-10-10" @default.
- W4281492015 title "Noninvasive biomarkers for the diagnosis and management of autoimmune hepatitis" @default.
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