Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281492643> ?p ?o ?g. }
- W4281492643 endingPage "825" @default.
- W4281492643 startingPage "825" @default.
- W4281492643 abstract "Tuberculosis (TB), caused by the human pathogen Mycobacterium tuberculosis (Mtb), is an infectious disease that presents a major threat to human health. Bacillus Calmette-Guérin (BCG), the only licensed TB vaccine, is ineffective against latent TB infection, necessitating the development of further TB drugs or therapeutic vaccines. Herein, we evaluated the therapeutic effect of a novel subunit vaccine AEC/BC02 after chemotherapy in a spontaneous Mtb relapse model. Immunotherapy followed 4 weeks of treatment with isoniazid and rifapentine, and bacterial loads in organs, pathological changes, and adaptive immune characteristics were investigated. The results showed slowly increased bacterial loads in the spleen and lungs of mice inoculated with AEC/BC02 with significantly lower loads than those of the control groups. Pathological scores for the liver, spleen, and lungs decreased accordingly. Moreover, AEC/BC02 induced antigen-specific IFN-γ-secreting or IL-2-secreting cellular immune responses, which decreased with the number of immunizations and times. Obvious Ag85b- and EC-specific IgG were observed in mice following the treatment with AEC/BC02, indicating a significant Th1-biased response. Taken together, these data suggest that AEC/BC02 immunotherapy post-chemotherapy may shorten future TB treatment." @default.
- W4281492643 created "2022-05-26" @default.
- W4281492643 creator A5001045957 @default.
- W4281492643 creator A5005586286 @default.
- W4281492643 creator A5008845556 @default.
- W4281492643 creator A5020415389 @default.
- W4281492643 creator A5024101693 @default.
- W4281492643 creator A5025024898 @default.
- W4281492643 creator A5028919210 @default.
- W4281492643 creator A5053292671 @default.
- W4281492643 date "2022-05-23" @default.
- W4281492643 modified "2023-10-05" @default.
- W4281492643 title "Therapeutic Effect of Subunit Vaccine AEC/BC02 on Mycobacterium tuberculosis Post-Chemotherapy Relapse Using a Latent Infection Murine Model" @default.
- W4281492643 cites W1498590626 @default.
- W4281492643 cites W1546213590 @default.
- W4281492643 cites W1588876880 @default.
- W4281492643 cites W1592760947 @default.
- W4281492643 cites W1902026070 @default.
- W4281492643 cites W1970021707 @default.
- W4281492643 cites W1977900381 @default.
- W4281492643 cites W1996364719 @default.
- W4281492643 cites W1998664439 @default.
- W4281492643 cites W2010318115 @default.
- W4281492643 cites W2025951355 @default.
- W4281492643 cites W2031750196 @default.
- W4281492643 cites W2060333387 @default.
- W4281492643 cites W2066091327 @default.
- W4281492643 cites W2083234984 @default.
- W4281492643 cites W2106682613 @default.
- W4281492643 cites W2125049374 @default.
- W4281492643 cites W2131715198 @default.
- W4281492643 cites W2131995938 @default.
- W4281492643 cites W2147339483 @default.
- W4281492643 cites W2153317865 @default.
- W4281492643 cites W2196673026 @default.
- W4281492643 cites W2338940156 @default.
- W4281492643 cites W2347132389 @default.
- W4281492643 cites W2437228747 @default.
- W4281492643 cites W2512141013 @default.
- W4281492643 cites W2516938750 @default.
- W4281492643 cites W2524340104 @default.
- W4281492643 cites W2539134479 @default.
- W4281492643 cites W2557666166 @default.
- W4281492643 cites W2587862424 @default.
- W4281492643 cites W2593652139 @default.
- W4281492643 cites W2608290060 @default.
- W4281492643 cites W2741667950 @default.
- W4281492643 cites W2756158128 @default.
- W4281492643 cites W2762649195 @default.
- W4281492643 cites W2791997229 @default.
- W4281492643 cites W2794434563 @default.
- W4281492643 cites W2797540534 @default.
- W4281492643 cites W2808292810 @default.
- W4281492643 cites W2885023327 @default.
- W4281492643 cites W2955596290 @default.
- W4281492643 cites W2980430960 @default.
- W4281492643 cites W2997968756 @default.
- W4281492643 cites W3035078779 @default.
- W4281492643 cites W3086676449 @default.
- W4281492643 cites W3135682442 @default.
- W4281492643 cites W3174664533 @default.
- W4281492643 cites W4235935369 @default.
- W4281492643 doi "https://doi.org/10.3390/vaccines10050825" @default.
- W4281492643 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35632581" @default.
- W4281492643 hasPublicationYear "2022" @default.
- W4281492643 type Work @default.
- W4281492643 citedByCount "13" @default.
- W4281492643 countsByYear W42814926432022 @default.
- W4281492643 countsByYear W42814926432023 @default.
- W4281492643 crossrefType "journal-article" @default.
- W4281492643 hasAuthorship W4281492643A5001045957 @default.
- W4281492643 hasAuthorship W4281492643A5005586286 @default.
- W4281492643 hasAuthorship W4281492643A5008845556 @default.
- W4281492643 hasAuthorship W4281492643A5020415389 @default.
- W4281492643 hasAuthorship W4281492643A5024101693 @default.
- W4281492643 hasAuthorship W4281492643A5025024898 @default.
- W4281492643 hasAuthorship W4281492643A5028919210 @default.
- W4281492643 hasAuthorship W4281492643A5053292671 @default.
- W4281492643 hasBestOaLocation W42814926431 @default.
- W4281492643 hasConcept C126322002 @default.
- W4281492643 hasConcept C142724271 @default.
- W4281492643 hasConcept C159047783 @default.
- W4281492643 hasConcept C203014093 @default.
- W4281492643 hasConcept C2776694085 @default.
- W4281492643 hasConcept C2776967927 @default.
- W4281492643 hasConcept C2776991065 @default.
- W4281492643 hasConcept C2777701055 @default.
- W4281492643 hasConcept C2777975735 @default.
- W4281492643 hasConcept C2779806340 @default.
- W4281492643 hasConcept C2780931953 @default.
- W4281492643 hasConcept C2781069245 @default.
- W4281492643 hasConcept C71924100 @default.
- W4281492643 hasConcept C8891405 @default.
- W4281492643 hasConceptScore W4281492643C126322002 @default.
- W4281492643 hasConceptScore W4281492643C142724271 @default.
- W4281492643 hasConceptScore W4281492643C159047783 @default.
- W4281492643 hasConceptScore W4281492643C203014093 @default.
- W4281492643 hasConceptScore W4281492643C2776694085 @default.