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- W4281493485 abstract "Cancer cells undergo alterations in lipid metabolism to support their high energy needs, tumorigenesis and evade an anti-tumor immune response. Alterations in fatty acid production are controlled by multiple enzymes, chiefly Acetyl CoA Carboxylase, ATP-Citrate Lyase, Fatty Acid Synthase, and Stearoyl CoA Desaturase 1. Ovarian cancer (OC) is a common gynecological malignancy with a high rate of aggressive carcinoma progression and drug resistance. The accumulation of unsaturated fatty acids in ovarian cancer supports cell growth, increased cancer cell migration, and worse patient outcomes. Ovarian cancer cells also expand their lipid stores via increased uptake of lipids using fatty acid translocases, fatty acid-binding proteins, and low-density lipoprotein receptors. Furthermore, increased lipogenesis and lipid uptake promote chemotherapy resistance and dampen the adaptive immune response needed to eliminate tumors. In this review, we discuss the role of lipid synthesis and metabolism in driving tumorigenesis and drug resistance in ovarian cancer conferring poor prognosis and outcomes in patients. We also cover some aspects of how lipids fuel ovarian cancer stem cells, and how these metabolic alterations in intracellular lipid content could potentially serve as biomarkers of ovarian cancer." @default.
- W4281493485 created "2022-05-26" @default.
- W4281493485 creator A5004198026 @default.
- W4281493485 creator A5017022810 @default.
- W4281493485 creator A5051732343 @default.
- W4281493485 date "2022-05-25" @default.
- W4281493485 modified "2023-10-01" @default.
- W4281493485 title "Targeting lipid metabolism in the treatment of ovarian cancer" @default.
- W4281493485 cites W1490315563 @default.
- W4281493485 cites W1878535762 @default.
- W4281493485 cites W1933223040 @default.
- W4281493485 cites W1967482096 @default.
- W4281493485 cites W1972462355 @default.
- W4281493485 cites W1973417968 @default.
- W4281493485 cites W1973963113 @default.
- W4281493485 cites W1978099625 @default.
- W4281493485 cites W1978281808 @default.
- W4281493485 cites W1986234170 @default.
- W4281493485 cites W1991328178 @default.
- W4281493485 cites W1997435180 @default.
- W4281493485 cites W2004161103 @default.
- W4281493485 cites W2005959174 @default.
- W4281493485 cites W2010696996 @default.
- W4281493485 cites W2010854970 @default.
- W4281493485 cites W2014349355 @default.
- W4281493485 cites W2015012139 @default.
- W4281493485 cites W2016921045 @default.
- W4281493485 cites W2017399995 @default.
- W4281493485 cites W2019865561 @default.
- W4281493485 cites W2020773529 @default.
- W4281493485 cites W2021844025 @default.
- W4281493485 cites W2027273582 @default.
- W4281493485 cites W2027699337 @default.
- W4281493485 cites W2030901818 @default.
- W4281493485 cites W2035536340 @default.
- W4281493485 cites W2035851178 @default.
- W4281493485 cites W2036292773 @default.
- W4281493485 cites W2037073070 @default.
- W4281493485 cites W2039524626 @default.
- W4281493485 cites W2041237929 @default.
- W4281493485 cites W2041830158 @default.
- W4281493485 cites W2045868505 @default.
- W4281493485 cites W2048540822 @default.
- W4281493485 cites W2056785598 @default.
- W4281493485 cites W2056950140 @default.
- W4281493485 cites W2059273277 @default.
- W4281493485 cites W2066783138 @default.
- W4281493485 cites W2067278135 @default.
- W4281493485 cites W2067783339 @default.
- W4281493485 cites W2086546138 @default.
- W4281493485 cites W2094003769 @default.
- W4281493485 cites W2097080554 @default.
- W4281493485 cites W2097259163 @default.
- W4281493485 cites W2098918967 @default.
- W4281493485 cites W2104424545 @default.
- W4281493485 cites W2112237903 @default.
- W4281493485 cites W2113334939 @default.
- W4281493485 cites W2118408423 @default.
- W4281493485 cites W2119732456 @default.
- W4281493485 cites W2127229383 @default.
- W4281493485 cites W2127451310 @default.
- W4281493485 cites W2127791131 @default.
- W4281493485 cites W2134480742 @default.
- W4281493485 cites W2137642531 @default.
- W4281493485 cites W2138110344 @default.
- W4281493485 cites W2143632660 @default.
- W4281493485 cites W2144343828 @default.
- W4281493485 cites W2149840294 @default.
- W4281493485 cites W2168347591 @default.
- W4281493485 cites W2170597525 @default.
- W4281493485 cites W2171874512 @default.
- W4281493485 cites W2199649852 @default.
- W4281493485 cites W2265836483 @default.
- W4281493485 cites W2283847485 @default.
- W4281493485 cites W2317648720 @default.
- W4281493485 cites W2399745752 @default.
- W4281493485 cites W2401957611 @default.
- W4281493485 cites W2405951222 @default.
- W4281493485 cites W2408904158 @default.
- W4281493485 cites W2443189794 @default.
- W4281493485 cites W2471044485 @default.
- W4281493485 cites W2507118233 @default.
- W4281493485 cites W2519193025 @default.
- W4281493485 cites W2560396365 @default.
- W4281493485 cites W2566405543 @default.
- W4281493485 cites W2589658059 @default.
- W4281493485 cites W2604165468 @default.
- W4281493485 cites W2605321533 @default.
- W4281493485 cites W2607206893 @default.
- W4281493485 cites W2623068422 @default.
- W4281493485 cites W2697143151 @default.
- W4281493485 cites W2700962337 @default.
- W4281493485 cites W2741135377 @default.
- W4281493485 cites W2755306738 @default.
- W4281493485 cites W2763905191 @default.
- W4281493485 cites W2767381389 @default.
- W4281493485 cites W2774913487 @default.
- W4281493485 cites W2783366082 @default.