FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281493637> ?p ?o ?g. }

• W4281493637 abstract "Abstract Background Monoiodoacetate (MIA)-induced arthritis models are used widely in osteoarthritis (OA) research to develop effective conservative treatments for hip OA, as an alternative to joint replacement surgery. In joint OA models, such as the MIA-induced knee OA model, various doses of MIA are utilized, depending on the purpose of the research. So far, only 2 mg of MIA has been used for MIA-induced hip OA research. We hypothesized that the amount of MIA should be adjusted according to the osteoarthritis model under investigation. We performed radiographic and histological evaluations in rats for hip OA models induced by different doses of MIA. Methods One hundred and eighty right hips of six-week-old, male Sprague–Dawley rats ( n = 30 rats per group) were treated with either a single intra-articular injection of various doses of MIA (0.25, 0.5, 1.0, 2.0, and 4.0 mg) dissolved in 25 μl of sterile saline (MIA group), or with 25 μl of sterile saline alone (Sham group). Radiographic and histological evaluations of the hip joint were performed at one, two, four, eight, and 12 weeks after administration ( n = 6 rats per group per time point). Results OA changes progressed from 1 week after administration in the 1.0-mg, 2.0-mg, and 4.0-mg MIA groups. The degree of OA changes increased as the dose of MIA increased. The 0.25-mg and 0.5-mg MIA groups presented fewer OA changes than the 2.0-mg and 4.0-mg MIA groups during the entire study period (up to 12 weeks). The administration of 0.25 mg and 0.5 mg of MIA-induced both radiographic and histological OA changes in a time-dependent manner, whereas more than 2 mg of MIA provoked end-stage OA at 8 weeks after injection. Absolute, dose-dependent histopathological OA changes were observed 4 weeks after MIA administration. Conclusions Intra-articular MIA injection to the hip joints of rats induced diverse OA changes dose-dependently. Research for developing novel conservative treatments for hip OA and intractable pain should consider the pathological condition when determining the dose of MIA to be employed." @default.
• W4281493637 created "2022-05-26" @default.
• W4281493637 creator A5010917785 @default.
• W4281493637 creator A5011530088 @default.
• W4281493637 creator A5011848589 @default.
• W4281493637 creator A5034804236 @default.
• W4281493637 creator A5042113287 @default.
• W4281493637 creator A5051143832 @default.
• W4281493637 creator A5059011724 @default.
• W4281493637 creator A5072359896 @default.
• W4281493637 creator A5073733659 @default.
• W4281493637 creator A5074115820 @default.
• W4281493637 creator A5087889642 @default.
• W4281493637 date "2022-05-25" @default.
• W4281493637 modified "2023-09-30" @default.
• W4281493637 title "Intra-articular injection of monoiodoacetate induces diverse hip osteoarthritis in rats, depending on its dose" @default.
• W4281493637 cites W130249347 @default.
• W4281493637 cites W1967057044 @default.
• W4281493637 cites W1967113556 @default.
• W4281493637 cites W1968937965 @default.
• W4281493637 cites W1988441219 @default.
• W4281493637 cites W1993990835 @default.
• W4281493637 cites W2018393962 @default.
• W4281493637 cites W2019972898 @default.
• W4281493637 cites W2022219238 @default.
• W4281493637 cites W2098082628 @default.
• W4281493637 cites W2099427592 @default.
• W4281493637 cites W2109443157 @default.
• W4281493637 cites W2115601182 @default.
• W4281493637 cites W2117040516 @default.
• W4281493637 cites W2133255767 @default.
• W4281493637 cites W2140513563 @default.
• W4281493637 cites W2153960708 @default.
• W4281493637 cites W2163024184 @default.
• W4281493637 cites W2163956223 @default.
• W4281493637 cites W2285319279 @default.
• W4281493637 cites W2300616782 @default.
• W4281493637 cites W2501898085 @default.
• W4281493637 cites W2508876487 @default.
• W4281493637 cites W2765567489 @default.
• W4281493637 cites W2808097672 @default.
• W4281493637 cites W2896403653 @default.
• W4281493637 cites W2973353799 @default.
• W4281493637 cites W2986998757 @default.
• W4281493637 cites W2992799944 @default.
• W4281493637 cites W3158766562 @default.
• W4281493637 cites W3211879702 @default.
• W4281493637 cites W4232225647 @default.
• W4281493637 doi "https://doi.org/10.1186/s12891-022-05454-y" @default.
• W4281493637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35614438" @default.
• W4281493637 hasPublicationYear "2022" @default.
• W4281493637 type Work @default.
• W4281493637 citedByCount "1" @default.
• W4281493637 countsByYear W42814936372022 @default.
• W4281493637 crossrefType "journal-article" @default.
• W4281493637 hasAuthorship W4281493637A5010917785 @default.
• W4281493637 hasAuthorship W4281493637A5011530088 @default.
• W4281493637 hasAuthorship W4281493637A5011848589 @default.
• W4281493637 hasAuthorship W4281493637A5034804236 @default.
• W4281493637 hasAuthorship W4281493637A5042113287 @default.
• W4281493637 hasAuthorship W4281493637A5051143832 @default.
• W4281493637 hasAuthorship W4281493637A5059011724 @default.
• W4281493637 hasAuthorship W4281493637A5072359896 @default.
• W4281493637 hasAuthorship W4281493637A5073733659 @default.
• W4281493637 hasAuthorship W4281493637A5074115820 @default.
• W4281493637 hasAuthorship W4281493637A5087889642 @default.
• W4281493637 hasBestOaLocation W42814936371 @default.
• W4281493637 hasConcept C126322002 @default.
• W4281493637 hasConcept C126894567 @default.
• W4281493637 hasConcept C141071460 @default.
• W4281493637 hasConcept C142724271 @default.
• W4281493637 hasConcept C1862650 @default.
• W4281493637 hasConcept C198451711 @default.
• W4281493637 hasConcept C204787440 @default.
• W4281493637 hasConcept C2775961468 @default.
• W4281493637 hasConcept C2776164576 @default.
• W4281493637 hasConcept C2777077863 @default.
• W4281493637 hasConcept C2777397205 @default.
• W4281493637 hasConcept C3019843197 @default.
• W4281493637 hasConcept C43893838 @default.
• W4281493637 hasConcept C68312169 @default.
• W4281493637 hasConcept C71924100 @default.
• W4281493637 hasConceptScore W4281493637C126322002 @default.
• W4281493637 hasConceptScore W4281493637C126894567 @default.
• W4281493637 hasConceptScore W4281493637C141071460 @default.
• W4281493637 hasConceptScore W4281493637C142724271 @default.
• W4281493637 hasConceptScore W4281493637C1862650 @default.
• W4281493637 hasConceptScore W4281493637C198451711 @default.
• W4281493637 hasConceptScore W4281493637C204787440 @default.
• W4281493637 hasConceptScore W4281493637C2775961468 @default.
• W4281493637 hasConceptScore W4281493637C2776164576 @default.
• W4281493637 hasConceptScore W4281493637C2777077863 @default.
• W4281493637 hasConceptScore W4281493637C2777397205 @default.
• W4281493637 hasConceptScore W4281493637C3019843197 @default.
• W4281493637 hasConceptScore W4281493637C43893838 @default.
• W4281493637 hasConceptScore W4281493637C68312169 @default.
• W4281493637 hasConceptScore W4281493637C71924100 @default.
• W4281493637 hasFunder F4320310759 @default.
• W4281493637 hasFunder F4320334764 @default.
• W4281493637 hasIssue "1" @default.

• next