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- W4281550140 endingPage "273" @default.
- W4281550140 startingPage "249" @default.
- W4281550140 abstract "Glioblastoma (GBM) is a deadly malignancy with a poor prognosis. An important factor contributing to GBM recurrence is high resistance of GBM cancer stem cells (GSCs). While temozolomide (TMZ), has been shown to consistently extend survival, GSCs grow resistant to TMZ through upregulation of DNA damage repair mechanisms and avoidance of apoptosis. Since a single-drug approach has failed to significantly alter prognosis in the past 15 years, unique approaches such as multidrug combination therapy together with distinctive targeted drug-delivery approaches against cancer stem cells are needed. In this review, a rationale for multidrug therapy using a targeted nanotechnology approach that preferentially target GSCs is proposed with discussion and examples of drugs, nanomedicine delivery systems, and targeting moieties." @default.
- W4281550140 created "2022-05-27" @default.
- W4281550140 creator A5017741675 @default.
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- W4281550140 creator A5068363616 @default.
- W4281550140 creator A5070128017 @default.
- W4281550140 creator A5089265440 @default.
- W4281550140 date "2022-04-01" @default.
- W4281550140 modified "2023-10-14" @default.
- W4281550140 title "Novel therapeutics and drug-delivery approaches in the modulation of glioblastoma stem cell resistance" @default.
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