FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281550403> ?p ?o ?g. }

• W4281550403 endingPage "1526" @default.
• W4281550403 startingPage "1514" @default.
• W4281550403 abstract "A series of novel dual A2A/A2B AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A2A AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or its open-ring bioisosteres. In addition, compound 7i displayed better inhibitory activity on A2B AR (IC50 14.12 nM) and higher potency in IL-2 production than AB928. Moreover, molecular docking studies were carried out to explain the rationality of molecular design and the activity of compound 7i. Further studies on 7f and 7i revealed good liver microsomes stabilities and acceptable in vivo PK profiles. This study provides insight into the future development of dual A2A/A2B AR antagonists for cancer immunotherapy." @default.
• W4281550403 created "2022-05-27" @default.
• W4281550403 creator A5010977397 @default.
• W4281550403 creator A5019056174 @default.
• W4281550403 creator A5040009629 @default.
• W4281550403 creator A5040303259 @default.
• W4281550403 creator A5059148106 @default.
• W4281550403 creator A5065296919 @default.
• W4281550403 creator A5068109019 @default.
• W4281550403 creator A5077742444 @default.
• W4281550403 creator A5079589648 @default.
• W4281550403 creator A5084437774 @default.
• W4281550403 date "2022-05-26" @default.
• W4281550403 modified "2023-10-14" @default.
• W4281550403 title "Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A_2A/A_2B adenosine receptor antagonists" @default.
• W4281550403 cites W1428818293 @default.
• W4281550403 cites W1546479459 @default.
• W4281550403 cites W1975740938 @default.
• W4281550403 cites W2003483275 @default.
• W4281550403 cites W2030703596 @default.
• W4281550403 cites W2083077426 @default.
• W4281550403 cites W2159945718 @default.
• W4281550403 cites W2160141570 @default.
• W4281550403 cites W2650642858 @default.
• W4281550403 cites W2731062074 @default.
• W4281550403 cites W2754993961 @default.
• W4281550403 cites W2791280007 @default.
• W4281550403 cites W2804822363 @default.
• W4281550403 cites W2896442534 @default.
• W4281550403 cites W2900622866 @default.
• W4281550403 cites W2904967643 @default.
• W4281550403 cites W2952894777 @default.
• W4281550403 cites W2964057433 @default.
• W4281550403 cites W2979711396 @default.
• W4281550403 cites W2990564687 @default.
• W4281550403 cites W3008934877 @default.
• W4281550403 cites W3031067760 @default.
• W4281550403 cites W3036892182 @default.
• W4281550403 cites W3043058341 @default.
• W4281550403 cites W3109607854 @default.
• W4281550403 cites W3114493954 @default.
• W4281550403 cites W3117282943 @default.
• W4281550403 cites W3126679094 @default.
• W4281550403 cites W3128397093 @default.
• W4281550403 cites W3152730126 @default.
• W4281550403 cites W3175864259 @default.
• W4281550403 cites W3184230971 @default.
• W4281550403 cites W3195600424 @default.
• W4281550403 cites W3197671829 @default.
• W4281550403 cites W3205209733 @default.
• W4281550403 cites W3206486961 @default.
• W4281550403 doi "https://doi.org/10.1080/14756366.2022.2077731" @default.
• W4281550403 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35616298" @default.
• W4281550403 hasPublicationYear "2022" @default.
• W4281550403 type Work @default.
• W4281550403 citedByCount "2" @default.
• W4281550403 countsByYear W42815504032022 @default.
• W4281550403 countsByYear W42815504032023 @default.
• W4281550403 crossrefType "journal-article" @default.
• W4281550403 hasAuthorship W4281550403A5010977397 @default.
• W4281550403 hasAuthorship W4281550403A5019056174 @default.
• W4281550403 hasAuthorship W4281550403A5040009629 @default.
• W4281550403 hasAuthorship W4281550403A5040303259 @default.
• W4281550403 hasAuthorship W4281550403A5059148106 @default.
• W4281550403 hasAuthorship W4281550403A5065296919 @default.
• W4281550403 hasAuthorship W4281550403A5068109019 @default.
• W4281550403 hasAuthorship W4281550403A5077742444 @default.
• W4281550403 hasAuthorship W4281550403A5079589648 @default.
• W4281550403 hasAuthorship W4281550403A5084437774 @default.
• W4281550403 hasBestOaLocation W42815504031 @default.
• W4281550403 hasConcept C150903083 @default.
• W4281550403 hasConcept C159110408 @default.
• W4281550403 hasConcept C170493617 @default.
• W4281550403 hasConcept C178790620 @default.
• W4281550403 hasConcept C185592680 @default.
• W4281550403 hasConcept C202751555 @default.
• W4281550403 hasConcept C207001950 @default.
• W4281550403 hasConcept C21951064 @default.
• W4281550403 hasConcept C2776309666 @default.
• W4281550403 hasConcept C2776885963 @default.
• W4281550403 hasConcept C2777752497 @default.
• W4281550403 hasConcept C2777907353 @default.
• W4281550403 hasConcept C2779321679 @default.
• W4281550403 hasConcept C41685203 @default.
• W4281550403 hasConcept C55493867 @default.
• W4281550403 hasConcept C57992300 @default.
• W4281550403 hasConcept C71240020 @default.
• W4281550403 hasConcept C71924100 @default.
• W4281550403 hasConcept C86803240 @default.
• W4281550403 hasConcept C87644729 @default.
• W4281550403 hasConcept C98274493 @default.
• W4281550403 hasConceptScore W4281550403C150903083 @default.
• W4281550403 hasConceptScore W4281550403C159110408 @default.
• W4281550403 hasConceptScore W4281550403C170493617 @default.
• W4281550403 hasConceptScore W4281550403C178790620 @default.
• W4281550403 hasConceptScore W4281550403C185592680 @default.
• W4281550403 hasConceptScore W4281550403C202751555 @default.
• W4281550403 hasConceptScore W4281550403C207001950 @default.

• next