Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281551160> ?p ?o ?g. }
- W4281551160 endingPage "546" @default.
- W4281551160 startingPage "534" @default.
- W4281551160 abstract "Background: Lung cancer is the leading cause of cancer death in most countries. Although early diagnosis and treatment critically influence prognosis, lung cancers are generally only discovered in the late stages of the disease. Objective: Widely-used screening and diagnostic methods are not suitable for preventive screening, and high-throughput technologies based on serum biomarkers are needed. Methods: We screened 501 serum samples, including 224 lung cancer (LC), 126 disease control (DC), and 151 healthy donor (HC) samples for new serum autoantibodies as biomarkers in the early diagnosis of lung cancer. In phase I, we used HuProtTM microarrays to perform preliminary serum antibody screening on 24 LC and 24 HC samples. In phase II, we screened 60 LC, 60 DC, and 60 HC serum samples using focused arrays constructed with 22 of the candidate autoantibody biomarkers screened out in phase I. Results: After data modeling and validation, we selected four potential early LC protein biomarker candidates, IL2RB, CENPB, TP53, and XAGE1A, with individual specificities >90% and sensitivities ranging from 21.2% to 32.2%. These four biomarkers had a specificity of >90% and a sensitivity of >65.5% for early LC when they combined in a panel. Further evaluation of these four biomarker candidates using ELISA assays and 273 serum samples (140 LC, 66 DC, and 67 HC) gave similar results (specificity of >91.7%, sensitivity >61.43%). Conclusion: IL2RB, CENPB, TP53, and XAGE1A combined biomarker panel holds potential for rapid screening and improving the diagnosis of early-stage LC, thus potentially also improving its prognosis." @default.
- W4281551160 created "2022-05-27" @default.
- W4281551160 creator A5003019825 @default.
- W4281551160 creator A5008471907 @default.
- W4281551160 creator A5017092885 @default.
- W4281551160 creator A5027111370 @default.
- W4281551160 creator A5035317876 @default.
- W4281551160 creator A5042416654 @default.
- W4281551160 creator A5060002817 @default.
- W4281551160 creator A5087822045 @default.
- W4281551160 date "2023-08-01" @default.
- W4281551160 modified "2023-09-27" @default.
- W4281551160 title "Serum Biomarker Panel for Rapid Early Diagnosis of Lung Cancer" @default.
- W4281551160 cites W1213336605 @default.
- W4281551160 cites W130099911 @default.
- W4281551160 cites W1757407923 @default.
- W4281551160 cites W1967112185 @default.
- W4281551160 cites W1985594917 @default.
- W4281551160 cites W1988014376 @default.
- W4281551160 cites W2034269086 @default.
- W4281551160 cites W2035618305 @default.
- W4281551160 cites W2061932411 @default.
- W4281551160 cites W2065432064 @default.
- W4281551160 cites W2076272738 @default.
- W4281551160 cites W2088720324 @default.
- W4281551160 cites W2095138364 @default.
- W4281551160 cites W2096844390 @default.
- W4281551160 cites W2097814320 @default.
- W4281551160 cites W2113396130 @default.
- W4281551160 cites W2124878371 @default.
- W4281551160 cites W2126901657 @default.
- W4281551160 cites W2128059998 @default.
- W4281551160 cites W2128450902 @default.
- W4281551160 cites W2129769331 @default.
- W4281551160 cites W2133006389 @default.
- W4281551160 cites W2143899846 @default.
- W4281551160 cites W2147796863 @default.
- W4281551160 cites W2148876339 @default.
- W4281551160 cites W2148977892 @default.
- W4281551160 cites W2171697262 @default.
- W4281551160 cites W2178408458 @default.
- W4281551160 cites W2332885956 @default.
- W4281551160 cites W2346651667 @default.
- W4281551160 cites W2418297050 @default.
- W4281551160 cites W2532684607 @default.
- W4281551160 cites W2537127006 @default.
- W4281551160 cites W2559588208 @default.
- W4281551160 cites W2570618306 @default.
- W4281551160 cites W2755864482 @default.
- W4281551160 cites W2761050422 @default.
- W4281551160 cites W2781525129 @default.
- W4281551160 cites W2889646458 @default.
- W4281551160 cites W2902025537 @default.
- W4281551160 cites W2945291503 @default.
- W4281551160 cites W2999673403 @default.
- W4281551160 cites W3031536151 @default.
- W4281551160 cites W4211133103 @default.
- W4281551160 cites W4233648682 @default.
- W4281551160 cites W4294107304 @default.
- W4281551160 doi "https://doi.org/10.2174/1568009622666220523154333" @default.
- W4281551160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35616661" @default.
- W4281551160 hasPublicationYear "2023" @default.
- W4281551160 type Work @default.
- W4281551160 citedByCount "1" @default.
- W4281551160 countsByYear W42815511602022 @default.
- W4281551160 crossrefType "journal-article" @default.
- W4281551160 hasAuthorship W4281551160A5003019825 @default.
- W4281551160 hasAuthorship W4281551160A5008471907 @default.
- W4281551160 hasAuthorship W4281551160A5017092885 @default.
- W4281551160 hasAuthorship W4281551160A5027111370 @default.
- W4281551160 hasAuthorship W4281551160A5035317876 @default.
- W4281551160 hasAuthorship W4281551160A5042416654 @default.
- W4281551160 hasAuthorship W4281551160A5060002817 @default.
- W4281551160 hasAuthorship W4281551160A5087822045 @default.
- W4281551160 hasConcept C104317684 @default.
- W4281551160 hasConcept C121608353 @default.
- W4281551160 hasConcept C124535831 @default.
- W4281551160 hasConcept C126322002 @default.
- W4281551160 hasConcept C143998085 @default.
- W4281551160 hasConcept C150194340 @default.
- W4281551160 hasConcept C159654299 @default.
- W4281551160 hasConcept C163764329 @default.
- W4281551160 hasConcept C186836561 @default.
- W4281551160 hasConcept C195814341 @default.
- W4281551160 hasConcept C203014093 @default.
- W4281551160 hasConcept C2776256026 @default.
- W4281551160 hasConcept C2781197716 @default.
- W4281551160 hasConcept C46111723 @default.
- W4281551160 hasConcept C55493867 @default.
- W4281551160 hasConcept C71924100 @default.
- W4281551160 hasConcept C86803240 @default.
- W4281551160 hasConceptScore W4281551160C104317684 @default.
- W4281551160 hasConceptScore W4281551160C121608353 @default.
- W4281551160 hasConceptScore W4281551160C124535831 @default.
- W4281551160 hasConceptScore W4281551160C126322002 @default.
- W4281551160 hasConceptScore W4281551160C143998085 @default.
- W4281551160 hasConceptScore W4281551160C150194340 @default.
- W4281551160 hasConceptScore W4281551160C159654299 @default.