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• W4281551330 endingPage "247" @default.
• W4281551330 startingPage "233" @default.
• W4281551330 abstract "Aim: In this study, brinzolamide (BRZ) was loaded in balafilcon A silicone hydrogel soft contact lens to enhance delivery in glaucoma therapy. Materials & methods: BRZ-loaded soft contact lens was prepared by the soaking method with optimization of pH, temperature and concentration of drug loading solution. Results: At pH 7.4, loading temperature and concentration of 32°C and 3 mg/ml, respectively, enhanced drug loading capacity and release were observed. Diffusional experiments showed Higuchi model of release. BRZ loading brought no appreciable changes in the physical properties of soft contact lens, likewise, maintaining stability. Conclusion: The results demonstrated BRZ loading and delivery through silicone hydrogel soft contact lens which provides a potential alternative in glaucoma therapy.Aim: In this study, brinzolamide (BRZ) was loaded in soft contact lens to improve drug delivery in glaucoma therapy. Materials & methods BRZ-loaded soft contact lens was prepared by the soaking method modifying pH, temperature and concentration of drug loading solution. Results: At pH 7.4, loading temperature and concentration of 32°C and 3 mg/ml, respectively, enhanced drug loading and release were observed. Diffusion is the main mechanism regulating drug release. BRZ loading brought no changes in the physical properties of soft contact lens, likewise, maintaining stability. Conclusion: The results demonstrated BRZ loading and delivery through soft contact lens which provides a potential alternative in glaucoma therapy." @default.
• W4281551330 created "2022-05-27" @default.
• W4281551330 creator A5028408540 @default.
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• W4281551330 date "2022-04-01" @default.
• W4281551330 modified "2023-10-06" @default.
• W4281551330 title "Brinzolamide-loaded soft contact lens for ophthalmic delivery" @default.
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• W4281551330 doi "https://doi.org/10.4155/tde-2022-0005" @default.
• W4281551330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35615865" @default.
• W4281551330 hasPublicationYear "2022" @default.
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