Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281551808> ?p ?o ?g. }
- W4281551808 endingPage "121863" @default.
- W4281551808 startingPage "121863" @default.
- W4281551808 abstract "Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval, numerous polymeric drugs and polymeric nanoparticles have entered the market as advanced or next-generation polymer-based therapeutics, while many others have currently been tested clinically. The polymer conjugation to therapeutic moiety offers several advantages, like enhanced solubilization of drug, controlled release, reduced immunogenicity, and prolonged circulation. The present review intends to highlight considerations in the design of therapeutically effective polymer-drug conjugates (PDCs), including the choice of linker chemistry. The potential synthetic strategies to formulate PDCs have been discussed along with recent advancements in the different types of PDCs, i.e., polymer-small molecular weight drug conjugates, polymer-protein conjugates, and stimuli-responsive PDCs, which are under clinical/preclinical investigation. Current impediments and regulatory hurdles hindering the clinical translation of PDC into effective therapeutic regimens for the amelioration of disease conditions have been addressed." @default.
- W4281551808 created "2022-05-27" @default.
- W4281551808 creator A5006694915 @default.
- W4281551808 creator A5013934398 @default.
- W4281551808 creator A5014881760 @default.
- W4281551808 creator A5030417466 @default.
- W4281551808 creator A5043499143 @default.
- W4281551808 creator A5060099979 @default.
- W4281551808 creator A5074973795 @default.
- W4281551808 date "2022-07-01" @default.
- W4281551808 modified "2023-10-17" @default.
- W4281551808 title "Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview" @default.
- W4281551808 cites W1478059225 @default.
- W4281551808 cites W1490299254 @default.
- W4281551808 cites W1555210583 @default.
- W4281551808 cites W1645621228 @default.
- W4281551808 cites W166778795 @default.
- W4281551808 cites W1819045417 @default.
- W4281551808 cites W1936637282 @default.
- W4281551808 cites W1937102262 @default.
- W4281551808 cites W1941244085 @default.
- W4281551808 cites W1964307788 @default.
- W4281551808 cites W1965889970 @default.
- W4281551808 cites W1967167579 @default.
- W4281551808 cites W1968640798 @default.
- W4281551808 cites W1971026321 @default.
- W4281551808 cites W1976041621 @default.
- W4281551808 cites W1978317679 @default.
- W4281551808 cites W1978486325 @default.
- W4281551808 cites W1978584972 @default.
- W4281551808 cites W1978654303 @default.
- W4281551808 cites W1981273187 @default.
- W4281551808 cites W1981453679 @default.
- W4281551808 cites W1982488307 @default.
- W4281551808 cites W1982915834 @default.
- W4281551808 cites W1983728177 @default.
- W4281551808 cites W1983775358 @default.
- W4281551808 cites W1984548348 @default.
- W4281551808 cites W1989236699 @default.
- W4281551808 cites W1990163407 @default.
- W4281551808 cites W1990687831 @default.
- W4281551808 cites W1994271543 @default.
- W4281551808 cites W1994936258 @default.
- W4281551808 cites W1995591348 @default.
- W4281551808 cites W1998187527 @default.
- W4281551808 cites W1999379061 @default.
- W4281551808 cites W2000691433 @default.
- W4281551808 cites W2001690617 @default.
- W4281551808 cites W2002007707 @default.
- W4281551808 cites W2002384766 @default.
- W4281551808 cites W2003610868 @default.
- W4281551808 cites W2003910065 @default.
- W4281551808 cites W2004248864 @default.
- W4281551808 cites W2007659821 @default.
- W4281551808 cites W2009419411 @default.
- W4281551808 cites W2010312818 @default.
- W4281551808 cites W2014562931 @default.
- W4281551808 cites W2015119937 @default.
- W4281551808 cites W2016867355 @default.
- W4281551808 cites W2016891616 @default.
- W4281551808 cites W2019729176 @default.
- W4281551808 cites W2021804758 @default.
- W4281551808 cites W2022745514 @default.
- W4281551808 cites W2022943495 @default.
- W4281551808 cites W2024315050 @default.
- W4281551808 cites W2024787650 @default.
- W4281551808 cites W2027847743 @default.
- W4281551808 cites W2028735371 @default.
- W4281551808 cites W2029263533 @default.
- W4281551808 cites W2030855909 @default.
- W4281551808 cites W2033674314 @default.
- W4281551808 cites W2034473786 @default.
- W4281551808 cites W2035309334 @default.
- W4281551808 cites W2036693197 @default.
- W4281551808 cites W2038443207 @default.
- W4281551808 cites W2038552054 @default.
- W4281551808 cites W2038882972 @default.
- W4281551808 cites W2039246109 @default.
- W4281551808 cites W2040273584 @default.
- W4281551808 cites W2041914114 @default.
- W4281551808 cites W2042940583 @default.
- W4281551808 cites W2043044122 @default.
- W4281551808 cites W2044637366 @default.
- W4281551808 cites W2046772999 @default.
- W4281551808 cites W2047387695 @default.
- W4281551808 cites W2047412840 @default.
- W4281551808 cites W2048115621 @default.
- W4281551808 cites W2049336362 @default.
- W4281551808 cites W2050492259 @default.
- W4281551808 cites W2054077680 @default.
- W4281551808 cites W2054770710 @default.
- W4281551808 cites W2055991021 @default.
- W4281551808 cites W2057498995 @default.
- W4281551808 cites W2061531844 @default.
- W4281551808 cites W2062549413 @default.
- W4281551808 cites W2065434939 @default.
- W4281551808 cites W2065735911 @default.
- W4281551808 cites W2065941395 @default.