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- W4281553897 abstract "Abstract The 3′‐end poly(A) tail is an important and potent feature of most mRNA molecules that affects mRNA fate and translation efficiency. Polyadenylation is a posttranscriptional process that occurs in the nucleus by canonical poly(A) polymerases (PAPs). In some specific instances, the poly(A) tail can also be extended in the cytoplasm by noncanonical poly(A) polymerases (ncPAPs). This epitranscriptomic regulation of mRNA recently became one of the most interesting aspects in the field. Advances in RNA sequencing technologies and software development have allowed the precise measurement of poly(A) tails, identification of new ncPAPs, expansion of the function of known enzymes, discovery and a better understanding of the physiological role of tail heterogeneity, and recognition of a correlation between tail length and RNA translatability. Here, we summarize the development of polyadenylation research methods, including classic low‐throughput approaches, Illumina‐based genome‐wide analysis, and advanced state‐of‐art techniques that utilize long‐read third‐generation sequencing with Pacific Biosciences and Oxford Nanopore Technologies platforms. A boost in technical opportunities over recent decades has allowed a better understanding of the regulation of gene expression at the mRNA level. This article is categorized under: RNA Methods > RNA Analyses In Vitro and In Silico" @default.
- W4281553897 created "2022-05-27" @default.
- W4281553897 creator A5005825789 @default.
- W4281553897 creator A5032490180 @default.
- W4281553897 creator A5036619595 @default.
- W4281553897 creator A5082888270 @default.
- W4281553897 date "2022-05-26" @default.
- W4281553897 modified "2023-10-09" @default.
- W4281553897 title "Measuring the tail: Methods for poly(A) tail profiling" @default.
- W4281553897 cites W1542762360 @default.
- W4281553897 cites W173012242 @default.
- W4281553897 cites W1963704405 @default.
- W4281553897 cites W1966711656 @default.
- W4281553897 cites W1974676736 @default.
- W4281553897 cites W1976019518 @default.
- W4281553897 cites W1988904557 @default.
- W4281553897 cites W1991397489 @default.
- W4281553897 cites W1993107878 @default.
- W4281553897 cites W1995824852 @default.
- W4281553897 cites W2005829737 @default.
- W4281553897 cites W2006378465 @default.
- W4281553897 cites W2009580887 @default.
- W4281553897 cites W2012852314 @default.
- W4281553897 cites W2025304958 @default.
- W4281553897 cites W2026570758 @default.
- W4281553897 cites W2026863186 @default.
- W4281553897 cites W2031707270 @default.
- W4281553897 cites W2032382786 @default.
- W4281553897 cites W2032828731 @default.
- W4281553897 cites W2034257028 @default.
- W4281553897 cites W2035268935 @default.
- W4281553897 cites W2036023356 @default.
- W4281553897 cites W203942436 @default.
- W4281553897 cites W2045565555 @default.
- W4281553897 cites W2049868101 @default.
- W4281553897 cites W2064641822 @default.
- W4281553897 cites W2066666252 @default.
- W4281553897 cites W2068767807 @default.
- W4281553897 cites W2070749983 @default.
- W4281553897 cites W2071138575 @default.
- W4281553897 cites W2071950386 @default.
- W4281553897 cites W2072770570 @default.
- W4281553897 cites W2074915514 @default.
- W4281553897 cites W2075443202 @default.
- W4281553897 cites W2076984671 @default.
- W4281553897 cites W2077746165 @default.
- W4281553897 cites W2078531707 @default.
- W4281553897 cites W2082514511 @default.
- W4281553897 cites W2087789109 @default.
- W4281553897 cites W2088453439 @default.
- W4281553897 cites W2094651035 @default.
- W4281553897 cites W2095370567 @default.
- W4281553897 cites W2100654035 @default.
- W4281553897 cites W2105775411 @default.
- W4281553897 cites W2106801137 @default.
- W4281553897 cites W2116486533 @default.
- W4281553897 cites W2120593461 @default.
- W4281553897 cites W2122795897 @default.
- W4281553897 cites W2123742352 @default.
- W4281553897 cites W2132322930 @default.
- W4281553897 cites W2132341951 @default.
- W4281553897 cites W2151562469 @default.
- W4281553897 cites W2152432732 @default.
- W4281553897 cites W2153401206 @default.
- W4281553897 cites W2161030070 @default.
- W4281553897 cites W2161160353 @default.
- W4281553897 cites W2164643779 @default.
- W4281553897 cites W2168760462 @default.
- W4281553897 cites W2169290305 @default.
- W4281553897 cites W2171324601 @default.
- W4281553897 cites W2231475773 @default.
- W4281553897 cites W2233880096 @default.
- W4281553897 cites W2295195360 @default.
- W4281553897 cites W2335434378 @default.
- W4281553897 cites W2347006509 @default.
- W4281553897 cites W2487617124 @default.
- W4281553897 cites W2493043445 @default.
- W4281553897 cites W2518030906 @default.
- W4281553897 cites W2525507785 @default.
- W4281553897 cites W2551764026 @default.
- W4281553897 cites W2605171817 @default.
- W4281553897 cites W2743879473 @default.
- W4281553897 cites W2765840555 @default.
- W4281553897 cites W2767360874 @default.
- W4281553897 cites W2767733991 @default.
- W4281553897 cites W2796449627 @default.
- W4281553897 cites W2800526695 @default.
- W4281553897 cites W2800606587 @default.
- W4281553897 cites W2801826986 @default.
- W4281553897 cites W2883511460 @default.
- W4281553897 cites W2884627335 @default.
- W4281553897 cites W2885113599 @default.
- W4281553897 cites W2894073648 @default.
- W4281553897 cites W2900014784 @default.
- W4281553897 cites W2900216082 @default.
- W4281553897 cites W2900372684 @default.
- W4281553897 cites W2903167102 @default.
- W4281553897 cites W2923706270 @default.
- W4281553897 cites W2926323761 @default.
- W4281553897 cites W2950063384 @default.