Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281553959> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W4281553959 abstract "Abstract Intervertebral disc degeneration (IDD) is the pathological reason of back pain and the therapeutic approaches are still unsatisfactory. Recently, mesenchymal stem cell-derived small extracellular vesicles (EVs) have emerged as the novel regenerative method for IDD. In this study, we intensively investigated the therapeutic mechanism of small EVs, and found that vasorin protein enriched in EVs promoted the proliferation and extracellular matrix anabolism of nucleus pulposus cells via the Notch1 signaling pathway. Then, we fabricated a thermoresponsive gel which composed of Pluronic F127 and decellularized extracellular matrix (FEC) for the delivery and sustained release of EVs. Besides, ex vivo and in vivo results showed that EVs embedded in FEC (EVs@FEC) ameliorate the disc degeneration efficiently and achieve better therapeutic effects than one-off EVs delivery. Collectively, these findings deepen the understanding of EVs mechanism in treating intervertebral disc degeneration, and also illustrate the promising capacity of sustained EVs release system for intervertebral disc regeneration." @default.
- W4281553959 created "2022-05-27" @default.
- W4281553959 creator A5012450574 @default.
- W4281553959 creator A5018073436 @default.
- W4281553959 creator A5020631350 @default.
- W4281553959 creator A5020727811 @default.
- W4281553959 creator A5039183169 @default.
- W4281553959 creator A5058329956 @default.
- W4281553959 creator A5059810617 @default.
- W4281553959 creator A5065328550 @default.
- W4281553959 creator A5065912071 @default.
- W4281553959 creator A5067575242 @default.
- W4281553959 creator A5074735359 @default.
- W4281553959 creator A5075504699 @default.
- W4281553959 creator A5088315672 @default.
- W4281553959 creator A5088769821 @default.
- W4281553959 creator A5090326176 @default.
- W4281553959 date "2022-05-25" @default.
- W4281553959 modified "2023-09-30" @default.
- W4281553959 title "Vasorin-abundant small extracellular vesicles retard intervertebral disc degeneration utilizing an injectable thermoresponsive delivery system" @default.
- W4281553959 doi "https://doi.org/10.21203/rs.3.rs-1640225/v1" @default.
- W4281553959 hasPublicationYear "2022" @default.
- W4281553959 type Work @default.
- W4281553959 citedByCount "0" @default.
- W4281553959 crossrefType "posted-content" @default.
- W4281553959 hasAuthorship W4281553959A5012450574 @default.
- W4281553959 hasAuthorship W4281553959A5018073436 @default.
- W4281553959 hasAuthorship W4281553959A5020631350 @default.
- W4281553959 hasAuthorship W4281553959A5020727811 @default.
- W4281553959 hasAuthorship W4281553959A5039183169 @default.
- W4281553959 hasAuthorship W4281553959A5058329956 @default.
- W4281553959 hasAuthorship W4281553959A5059810617 @default.
- W4281553959 hasAuthorship W4281553959A5065328550 @default.
- W4281553959 hasAuthorship W4281553959A5065912071 @default.
- W4281553959 hasAuthorship W4281553959A5067575242 @default.
- W4281553959 hasAuthorship W4281553959A5074735359 @default.
- W4281553959 hasAuthorship W4281553959A5075504699 @default.
- W4281553959 hasAuthorship W4281553959A5088315672 @default.
- W4281553959 hasAuthorship W4281553959A5088769821 @default.
- W4281553959 hasAuthorship W4281553959A5090326176 @default.
- W4281553959 hasBestOaLocation W42815539591 @default.
- W4281553959 hasConcept C105702510 @default.
- W4281553959 hasConcept C136229726 @default.
- W4281553959 hasConcept C142724271 @default.
- W4281553959 hasConcept C150903083 @default.
- W4281553959 hasConcept C171056886 @default.
- W4281553959 hasConcept C185592680 @default.
- W4281553959 hasConcept C189165786 @default.
- W4281553959 hasConcept C190672674 @default.
- W4281553959 hasConcept C198826908 @default.
- W4281553959 hasConcept C207001950 @default.
- W4281553959 hasConcept C26291073 @default.
- W4281553959 hasConcept C2777755357 @default.
- W4281553959 hasConcept C2779354088 @default.
- W4281553959 hasConcept C28406088 @default.
- W4281553959 hasConcept C71924100 @default.
- W4281553959 hasConcept C86803240 @default.
- W4281553959 hasConcept C95444343 @default.
- W4281553959 hasConceptScore W4281553959C105702510 @default.
- W4281553959 hasConceptScore W4281553959C136229726 @default.
- W4281553959 hasConceptScore W4281553959C142724271 @default.
- W4281553959 hasConceptScore W4281553959C150903083 @default.
- W4281553959 hasConceptScore W4281553959C171056886 @default.
- W4281553959 hasConceptScore W4281553959C185592680 @default.
- W4281553959 hasConceptScore W4281553959C189165786 @default.
- W4281553959 hasConceptScore W4281553959C190672674 @default.
- W4281553959 hasConceptScore W4281553959C198826908 @default.
- W4281553959 hasConceptScore W4281553959C207001950 @default.
- W4281553959 hasConceptScore W4281553959C26291073 @default.
- W4281553959 hasConceptScore W4281553959C2777755357 @default.
- W4281553959 hasConceptScore W4281553959C2779354088 @default.
- W4281553959 hasConceptScore W4281553959C28406088 @default.
- W4281553959 hasConceptScore W4281553959C71924100 @default.
- W4281553959 hasConceptScore W4281553959C86803240 @default.
- W4281553959 hasConceptScore W4281553959C95444343 @default.
- W4281553959 hasLocation W42815539591 @default.
- W4281553959 hasOpenAccess W4281553959 @default.
- W4281553959 hasPrimaryLocation W42815539591 @default.
- W4281553959 hasRelatedWork W10766190 @default.
- W4281553959 hasRelatedWork W2226909 @default.
- W4281553959 hasRelatedWork W26849349 @default.
- W4281553959 hasRelatedWork W26923789 @default.
- W4281553959 hasRelatedWork W31110946 @default.
- W4281553959 hasRelatedWork W32019318 @default.
- W4281553959 hasRelatedWork W33746831 @default.
- W4281553959 hasRelatedWork W34051461 @default.
- W4281553959 hasRelatedWork W34348768 @default.
- W4281553959 hasRelatedWork W655853 @default.
- W4281553959 isParatext "false" @default.
- W4281553959 isRetracted "false" @default.
- W4281553959 workType "article" @default.