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- W4281554814 abstract "Abstract Dysregulation of auto-reactive T cells and autoantibody-producing B cells and excessive inflammation are responsible for the occurrence and development of autoimmune diseases. The suppression of autoreactive T cell activation and autoantibody production, as well as inhibition of inflammatory cytokine production have been utilized to ameliorate autoimmune disease symptoms. However, the existing treatment strategies are not sufficient to cure autoimmune diseases since patients can quickly suffer a relapse following the end of treatments. Pattern recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLRs), RIG-I like receptors (RLRs), C-type lectin receptors (CLRs) and various nucleic acid sensors, are expressed in both innate and adaptive immune cells and are involved in the development of autoimmune diseases. Here, we have summarized advances of PRRs signaling pathways, association between PRRs and autoimmune diseases, application of inhibitors targeting PRRs and the corresponding signaling molecules relevant to strategies targeting autoimmune diseases. This review emphasizes the roles of different PRRs in activating both innate and adaptive immunity, which can coordinate to trigger autoimmune responses. The review may also prompt the formulation of novel ideas for developing therapeutic strategies against autoimmune diseases by targeting PRRs-related signals." @default.
- W4281554814 created "2022-05-27" @default.
- W4281554814 creator A5003759585 @default.
- W4281554814 creator A5005160163 @default.
- W4281554814 creator A5046774599 @default.
- W4281554814 creator A5071924385 @default.
- W4281554814 date "2022-05-26" @default.
- W4281554814 modified "2023-10-16" @default.
- W4281554814 title "Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases" @default.
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