FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281559979> ?p ?o ?g. }

• W4281559979 abstract "Luteolin (3',4',5,7‑tetrahydroxy flavone) is a flavonoid, which is widely distributed in various plants including flowers, vegetables, and medicinal herbs and spices. Luteolin can be applied in the treatment of various diseases due to its multiple biological activities, such as anti‑inflammatory, anticancer, and antioxidative activity. However, its role in intervertebral disc degeneration has not been previously reported. Therefore, the purpose of the present study was to explore the effects of luteolin on Tumor necrosis factor (TNF)‑α‑induced inflammatory injury and senescence of human nucleus pulposus cells (HNPCs), as well as the underlying mechanisms of action of this compound. Cell viability and apoptosis were assessed by MTT assay and TUNEL staining, respectively. ELISA kits were applied to detect the levels of inflammatory cytokines and the activity of telomerase. Senescence β‑galactosidase staining was used to detect the activity levels of β‑galactosidase in the cells. Cell transfection was performed to achieve interference of sirtuin 6 (Sirt6). The protein expression levels were detected by western blot analysis. TUNEL staining and western blot analysis were performed to assess the expression levels of apoptosis‑related proteins. The results indicated that TNF‑α induced a significant decrease in HNPC viability and an increase in inflammatory factor levels, while the application of luteolin effectively increased cell viability and decreased intracellular interleukin (IL)‑1β and IL‑6 expression levels. Furthermore, luteolin decreased apoptosis compared with the TNF‑α groups in a dose‑dependent manner. In addition, the results of the detection kits suggested that luteolin reversed TNF‑α‑induced senescence. Notably, interference with Sirt6 partially reduced the protective effect of luteolin on TNF‑α‑induced HNPC senescence via the Sirt6/NF‑κB pathway. In summary, the data indicated that luteolin suppresses TNF‑α‑induced inflammatory injury and senescence of HNPCs via the Sirt6/NF‑κB pathway." @default.
• W4281559979 created "2022-05-27" @default.
• W4281559979 creator A5011079375 @default.
• W4281559979 creator A5013460580 @default.
• W4281559979 creator A5016087317 @default.
• W4281559979 creator A5057088934 @default.
• W4281559979 creator A5073070877 @default.
• W4281559979 date "2022-05-26" @default.
• W4281559979 modified "2023-10-05" @default.
• W4281559979 title "Luteolin suppresses TNF‑α‑induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF‑κB pathway" @default.
• W4281559979 cites W1931704533 @default.
• W4281559979 cites W1989077880 @default.
• W4281559979 cites W2000723582 @default.
• W4281559979 cites W2009846643 @default.
• W4281559979 cites W2032955209 @default.
• W4281559979 cites W2040824755 @default.
• W4281559979 cites W2056564149 @default.
• W4281559979 cites W2061456864 @default.
• W4281559979 cites W2063084036 @default.
• W4281559979 cites W2068547085 @default.
• W4281559979 cites W2072936530 @default.
• W4281559979 cites W2073882423 @default.
• W4281559979 cites W2107277218 @default.
• W4281559979 cites W2109069677 @default.
• W4281559979 cites W2116112397 @default.
• W4281559979 cites W2140163728 @default.
• W4281559979 cites W2192080449 @default.
• W4281559979 cites W2589016670 @default.
• W4281559979 cites W2756763833 @default.
• W4281559979 cites W2761263615 @default.
• W4281559979 cites W2767757592 @default.
• W4281559979 cites W2793622197 @default.
• W4281559979 cites W2796922360 @default.
• W4281559979 cites W2804636211 @default.
• W4281559979 cites W2805158663 @default.
• W4281559979 cites W2902118901 @default.
• W4281559979 cites W2903534860 @default.
• W4281559979 cites W2917968580 @default.
• W4281559979 cites W2924329285 @default.
• W4281559979 cites W2969003985 @default.
• W4281559979 cites W2989876701 @default.
• W4281559979 cites W2997600695 @default.
• W4281559979 cites W3006300232 @default.
• W4281559979 cites W3010341671 @default.
• W4281559979 cites W3012168781 @default.
• W4281559979 cites W3028479423 @default.
• W4281559979 cites W3045445828 @default.
• W4281559979 cites W3046181019 @default.
• W4281559979 cites W3094267821 @default.
• W4281559979 cites W3105924436 @default.
• W4281559979 cites W3114154535 @default.
• W4281559979 cites W3114927754 @default.
• W4281559979 cites W3128846620 @default.
• W4281559979 cites W3143682753 @default.
• W4281559979 cites W3154538171 @default.
• W4281559979 cites W3164835730 @default.
• W4281559979 cites W3165341187 @default.
• W4281559979 cites W3177046881 @default.
• W4281559979 cites W3181805284 @default.
• W4281559979 cites W3197004207 @default.
• W4281559979 cites W3199343526 @default.
• W4281559979 doi "https://doi.org/10.3892/etm.2022.11396" @default.
• W4281559979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35747154" @default.
• W4281559979 hasPublicationYear "2022" @default.
• W4281559979 type Work @default.
• W4281559979 citedByCount "4" @default.
• W4281559979 countsByYear W42815599792022 @default.
• W4281559979 countsByYear W42815599792023 @default.
• W4281559979 crossrefType "journal-article" @default.
• W4281559979 hasAuthorship W4281559979A5011079375 @default.
• W4281559979 hasAuthorship W4281559979A5013460580 @default.
• W4281559979 hasAuthorship W4281559979A5016087317 @default.
• W4281559979 hasAuthorship W4281559979A5057088934 @default.
• W4281559979 hasAuthorship W4281559979A5073070877 @default.
• W4281559979 hasBestOaLocation W42815599791 @default.
• W4281559979 hasConcept C104317684 @default.
• W4281559979 hasConcept C153911025 @default.
• W4281559979 hasConcept C17991360 @default.
• W4281559979 hasConcept C185592680 @default.
• W4281559979 hasConcept C190283241 @default.
• W4281559979 hasConcept C196795494 @default.
• W4281559979 hasConcept C203014093 @default.
• W4281559979 hasConcept C2776080593 @default.
• W4281559979 hasConcept C2776415932 @default.
• W4281559979 hasConcept C2777730290 @default.
• W4281559979 hasConcept C2778004101 @default.
• W4281559979 hasConcept C2779054382 @default.
• W4281559979 hasConcept C2780783641 @default.
• W4281559979 hasConcept C53227056 @default.
• W4281559979 hasConcept C55493867 @default.
• W4281559979 hasConcept C86803240 @default.
• W4281559979 hasConcept C95444343 @default.
• W4281559979 hasConcept C98274493 @default.
• W4281559979 hasConceptScore W4281559979C104317684 @default.
• W4281559979 hasConceptScore W4281559979C153911025 @default.
• W4281559979 hasConceptScore W4281559979C17991360 @default.
• W4281559979 hasConceptScore W4281559979C185592680 @default.
• W4281559979 hasConceptScore W4281559979C190283241 @default.
• W4281559979 hasConceptScore W4281559979C196795494 @default.
• W4281559979 hasConceptScore W4281559979C203014093 @default.

• next