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- W4281561397 abstract "Diphyllin and its natural derivatives were identified as potent vacuolar H+ -ATPase (V-ATPase) inhibitors. In this study, twelve 2, 4, 5-trideoxyhexopyranosides derivatives of diphyllin were synthesized. Most of these compounds showed potent abilities to inhibit the growth of HT-29, MCF-7, HepG2 cancer cells with IC50 values at submicromolar concentration. The compounds 5c3 and 5c4 showed the best inhibitory activity on breast cancer cell lines MCF-7 with IC50 values of 0.09 and 0.10 μM. Compounds 5c3 and 5c4 showed similar V-ATPase inhibitory potency to diphyllin. Molecular docking showed that a hydrogen bond was found between the hydroxyl of 5c3 and SerA534 in the pocket of the V-ATPase receptor." @default.
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- W4281561397 date "2022-06-02" @default.
- W4281561397 modified "2023-10-04" @default.
- W4281561397 title "2, 4, <scp>5‐Trideoxyhexopyranosides</scp> Derivatives of Diphyllin: Synthesis and Anticancer activity" @default.
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- W4281561397 doi "https://doi.org/10.1111/cbdd.14095" @default.
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