Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281567149> ?p ?o ?g. }
- W4281567149 endingPage "1236" @default.
- W4281567149 startingPage "1236" @default.
- W4281567149 abstract "Oligodendrocytes are cells fundamental for brain functions as they form the myelin sheath and feed axons. They perform these critical functions thanks to the cooperation with other glial cells, mainly astrocytes. The astrocyte/oligodendrocyte crosstalk needs numerous mediators and receptors, such as peroxisome proliferator-activated receptors (PPARs). PPAR agonists promote oligodendrocyte precursor cells (OPCs) maturation in myelinating oligodendrocytes. In the Alzheimer’s disease brain, deposition of beta-amyloid (Aβ) has been linked to several alterations, including astrogliosis and changes in OPCs maturation. However, very little is known about the molecular mechanisms. Here, we investigated for the first time the maturation of OPCs co-cultured with astrocytes in an in vitro model of Aβ1–42 toxicity. We also tested the potential beneficial effect of the anti-inflammatory and neuroprotective composite palmitoylethanolamide and luteolin (co-ultra PEALut), which is known to engage the isoform alfa of the PPARs. Our results show that Aβ1–42 triggers astrocyte reactivity and inflammation and reduces the levels of growth factors important for OPCs maturation. Oligodendrocytes indeed show low cell surface area and few arborizations. Co-ultra PEALut counteracts the Aβ1–42-induced inflammation and astrocyte reactivity preserving the morphology of co-cultured oligodendrocytes through a mechanism that in some cases involves PPAR-α. This is the first evidence of the negative effects exerted by Aβ1–42 on astrocyte/oligodendrocyte crosstalk and discloses a never-explored co-ultra PEALut ability in restoring oligodendrocyte homeostasis." @default.
- W4281567149 created "2022-05-27" @default.
- W4281567149 creator A5022185376 @default.
- W4281567149 creator A5026440028 @default.
- W4281567149 creator A5033403935 @default.
- W4281567149 creator A5053643962 @default.
- W4281567149 creator A5069026332 @default.
- W4281567149 creator A5074044284 @default.
- W4281567149 creator A5079123795 @default.
- W4281567149 date "2022-05-26" @default.
- W4281567149 modified "2023-10-01" @default.
- W4281567149 title "Co-Ultramicronized Palmitoylethanolamide/Luteolin Restores Oligodendrocyte Homeostasis via Peroxisome Proliferator-Activated Receptor-α in an In Vitro Model of Alzheimer’s Disease" @default.
- W4281567149 cites W1544991924 @default.
- W4281567149 cites W1597614159 @default.
- W4281567149 cites W1647126819 @default.
- W4281567149 cites W1780440403 @default.
- W4281567149 cites W1867188294 @default.
- W4281567149 cites W1938046568 @default.
- W4281567149 cites W1973479349 @default.
- W4281567149 cites W1974390938 @default.
- W4281567149 cites W1981030744 @default.
- W4281567149 cites W1982691004 @default.
- W4281567149 cites W1985192341 @default.
- W4281567149 cites W1988595374 @default.
- W4281567149 cites W1989975126 @default.
- W4281567149 cites W1992765303 @default.
- W4281567149 cites W1993320204 @default.
- W4281567149 cites W1996718104 @default.
- W4281567149 cites W2004750343 @default.
- W4281567149 cites W2006593236 @default.
- W4281567149 cites W2006699056 @default.
- W4281567149 cites W2008582944 @default.
- W4281567149 cites W2018767861 @default.
- W4281567149 cites W2019942858 @default.
- W4281567149 cites W2026082154 @default.
- W4281567149 cites W2036940243 @default.
- W4281567149 cites W2037200077 @default.
- W4281567149 cites W2048638801 @default.
- W4281567149 cites W2050975036 @default.
- W4281567149 cites W2058959394 @default.
- W4281567149 cites W2082302366 @default.
- W4281567149 cites W2085973940 @default.
- W4281567149 cites W2092644527 @default.
- W4281567149 cites W2097232765 @default.
- W4281567149 cites W2099026515 @default.
- W4281567149 cites W2103650093 @default.
- W4281567149 cites W2107752044 @default.
- W4281567149 cites W2108244474 @default.
- W4281567149 cites W2118254221 @default.
- W4281567149 cites W2164942167 @default.
- W4281567149 cites W2165533183 @default.
- W4281567149 cites W2167279371 @default.
- W4281567149 cites W2168025729 @default.
- W4281567149 cites W2214706654 @default.
- W4281567149 cites W2289895672 @default.
- W4281567149 cites W2301137789 @default.
- W4281567149 cites W2306699765 @default.
- W4281567149 cites W2464556617 @default.
- W4281567149 cites W2469466281 @default.
- W4281567149 cites W2513219691 @default.
- W4281567149 cites W2554389950 @default.
- W4281567149 cites W2584394395 @default.
- W4281567149 cites W2735240222 @default.
- W4281567149 cites W2769464088 @default.
- W4281567149 cites W2770653478 @default.
- W4281567149 cites W2771523624 @default.
- W4281567149 cites W2773540472 @default.
- W4281567149 cites W2777525962 @default.
- W4281567149 cites W2783797280 @default.
- W4281567149 cites W2788331446 @default.
- W4281567149 cites W2792211025 @default.
- W4281567149 cites W2793877399 @default.
- W4281567149 cites W2802493769 @default.
- W4281567149 cites W2802764933 @default.
- W4281567149 cites W2805598377 @default.
- W4281567149 cites W2898142024 @default.
- W4281567149 cites W2905861053 @default.
- W4281567149 cites W2914660079 @default.
- W4281567149 cites W2928157366 @default.
- W4281567149 cites W2944147248 @default.
- W4281567149 cites W2948282677 @default.
- W4281567149 cites W2948989680 @default.
- W4281567149 cites W2950108987 @default.
- W4281567149 cites W2984544781 @default.
- W4281567149 cites W3001162363 @default.
- W4281567149 cites W3004287559 @default.
- W4281567149 cites W3009751543 @default.
- W4281567149 cites W3014448076 @default.
- W4281567149 cites W3032359734 @default.
- W4281567149 cites W3033481761 @default.
- W4281567149 cites W3089352106 @default.
- W4281567149 cites W3097943335 @default.
- W4281567149 cites W3103582367 @default.
- W4281567149 cites W3111607518 @default.
- W4281567149 cites W3132240972 @default.
- W4281567149 cites W3134247990 @default.
- W4281567149 cites W3153415807 @default.
- W4281567149 cites W3174994127 @default.