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• W4281567279 abstract "Abstract Establishing the biological basis of cognition and its disorders will require high precision spatiotemporal measurements of neural activity. Recently developed genetically encoded voltage indicators (GEVIs) report both spiking and subthreshold activity of identified neurons. However, maximally capitalising on the potential of GEVIs will require imaging at the millisecond time scales, which remains challenging with standard camera systems. Here we report application of single photon avalanche diode (SPAD) sensors to imaging neural activity at kilohertz frame rates. SPADs are electronic devices that when activated by a single photon cause an avalanche of electrons and a large electric current. We use an array of SPAD sensors to image individual neurons expressing genetically encoded voltage indicators. We show that subthreshold and spiking activity can be resolved with shot noise limited signals at frame rates of up to 10 kHz. SPAD imaging was able to reveal millisecond scale synchronisation of neural activity in an ex-vivo seizure model. SPAD sensors may have widespread applications for investigation of millisecond timescale neural dynamics. Table of contents The high temporal precision of single photon avalanche diodes (SPADs) is leveraged to record neural activity reported by genetically encoded voltage indicators. Sub-threshold and spiking activity of single neurons was resolved with shot noise limited signals at frame rates of up to 10 kHz. SPAD sensors may have widespread applications for neural imaging at high frame rates." @default.
• W4281567279 created "2022-05-27" @default.
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• W4281567279 date "2022-05-24" @default.
• W4281567279 modified "2023-10-17" @default.
• W4281567279 title "Single photon kilohertz frame rate imaging of neural activity" @default.
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• W4281567279 doi "https://doi.org/10.1101/2022.05.23.493031" @default.
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