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- W4281567457 abstract "We developed a novel asymmetric Friedel-Crafts alkylation/transamidation tandem reaction for the enantio- and diastereoselective synthesis of pyrazolo[3,4-b]pyridin-6-ones bearing a -CF3 unit via synergistic chiral phosphoric acid and MgSO4 catalysis. This [3 + 3] annulation protocol allows the formation of trifluoromethylated pyrazolo[3,4-b]pyridin-6-ones with two adjacent tertiary stereocenters in moderate to high yields (up to 90%), enantioselectivities (up to 97% ee), and diastereoselectivities (up to >20:1 dr)." @default.
- W4281567457 created "2022-05-27" @default.
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- W4281567457 date "2022-05-25" @default.
- W4281567457 modified "2023-10-18" @default.
- W4281567457 title "Asymmetric [3 + 3] Annulation to Construct Trifluoromethylated Pyrazolo[3,4-<i>b</i>]pyridin-6-ones via Chiral Phosphoric Acid and MgSO<sub>4</sub> Synergistic Catalysis" @default.
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- W4281567457 doi "https://doi.org/10.1021/acs.orglett.2c01513" @default.
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