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• W4281569137 abstract "The respiratory illness triggered by severe acute respiratory syndrome virus-2 (SARS-CoV-2) is often particularly serious or fatal amongst patients with pre-existing heart conditions. Although the mechanisms underlying SARS-CoV-2-related cardiac damage remain elusive, inflammation (i.e. 'cytokine storm') and oxidative stress are likely involved.Here we sought to determine: 1) if cardiomyocytes are targeted by SARS-CoV-2 and 2) how inflammation and oxidative stress promote the viral entry into cardiac cells. We analysed pro-inflammatory and oxidative stress and its impact on virus entry and virus-associated cardiac damage from SARS-CoV-2 infected patients and compared it to left ventricular myocardial tissues obtained from non-infected transplanted hearts either from end stage heart failure or non-failing hearts (donor group). We found that neuropilin-1 potentiates SARS-CoV-2 entry into human cardiomyocytes, a phenomenon driven by inflammatory and oxidant signals. These changes accounted for increased proteases activity and apoptotic markers thus leading to cell damage and apoptosis.This study provides new insights into the mechanisms of SARS-CoV-2 entry into the heart and defines promising targets for antiviral interventions for COVID-19 patients with pre-existing heart conditions or patients with co-morbidities." @default.
• W4281569137 created "2022-05-27" @default.
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• W4281569137 date "2022-09-01" @default.
• W4281569137 modified "2023-09-30" @default.
• W4281569137 title "SARS-CoV-2 infects human cardiomyocytes promoted by inflammation and oxidative stress" @default.
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• W4281569137 doi "https://doi.org/10.1016/j.ijcard.2022.05.055" @default.
• W4281569137 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35643215" @default.
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