Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281569242> ?p ?o ?g. }
- W4281569242 endingPage "86" @default.
- W4281569242 startingPage "80" @default.
- W4281569242 abstract "Activation of microglia in the spinal cord dorsal horn after peripheral nerve injury contributes to the development of pain hypersensitivity. How activated microglia selectively enhance the activity of spinal nociceptive circuits is not well understood. We discovered that after peripheral nerve injury, microglia degrade extracellular matrix structures, perineuronal nets (PNNs), in lamina I of the spinal cord dorsal horn. Lamina I PNNs selectively enwrap spinoparabrachial projection neurons, which integrate nociceptive information in the spinal cord and convey it to supraspinal brain regions to induce pain sensation. Degradation of PNNs by microglia enhances the activity of projection neurons and induces pain-related behaviors. Thus, nerve injury–induced degradation of PNNs is a mechanism by which microglia selectively augment the output of spinal nociceptive circuits and cause pain hypersensitivity." @default.
- W4281569242 created "2022-05-27" @default.
- W4281569242 creator A5001518887 @default.
- W4281569242 creator A5004685940 @default.
- W4281569242 creator A5005776897 @default.
- W4281569242 creator A5008683790 @default.
- W4281569242 creator A5009011998 @default.
- W4281569242 creator A5014486667 @default.
- W4281569242 creator A5017328884 @default.
- W4281569242 creator A5017383692 @default.
- W4281569242 creator A5023021185 @default.
- W4281569242 creator A5032853383 @default.
- W4281569242 creator A5037541410 @default.
- W4281569242 creator A5038502044 @default.
- W4281569242 creator A5041185154 @default.
- W4281569242 creator A5041473246 @default.
- W4281569242 creator A5047306210 @default.
- W4281569242 creator A5052015413 @default.
- W4281569242 creator A5052557530 @default.
- W4281569242 creator A5053795308 @default.
- W4281569242 creator A5071565653 @default.
- W4281569242 creator A5073443931 @default.
- W4281569242 creator A5077546094 @default.
- W4281569242 creator A5078028262 @default.
- W4281569242 creator A5081202655 @default.
- W4281569242 creator A5082583100 @default.
- W4281569242 date "2022-07-01" @default.
- W4281569242 modified "2023-10-10" @default.
- W4281569242 title "Microglia-mediated degradation of perineuronal nets promotes pain" @default.
- W4281569242 cites W1978269241 @default.
- W4281569242 cites W1996195292 @default.
- W4281569242 cites W1997218140 @default.
- W4281569242 cites W2012928251 @default.
- W4281569242 cites W2017343522 @default.
- W4281569242 cites W2020098484 @default.
- W4281569242 cites W2047010161 @default.
- W4281569242 cites W2049938995 @default.
- W4281569242 cites W2074966254 @default.
- W4281569242 cites W2091187766 @default.
- W4281569242 cites W2115855931 @default.
- W4281569242 cites W2125814499 @default.
- W4281569242 cites W2161057248 @default.
- W4281569242 cites W2163470859 @default.
- W4281569242 cites W2168250283 @default.
- W4281569242 cites W2172201406 @default.
- W4281569242 cites W2195259275 @default.
- W4281569242 cites W2196308323 @default.
- W4281569242 cites W2395203167 @default.
- W4281569242 cites W2421777402 @default.
- W4281569242 cites W2469773095 @default.
- W4281569242 cites W2527794060 @default.
- W4281569242 cites W2547373552 @default.
- W4281569242 cites W2565754955 @default.
- W4281569242 cites W2735735043 @default.
- W4281569242 cites W2753593979 @default.
- W4281569242 cites W2767383793 @default.
- W4281569242 cites W2773803332 @default.
- W4281569242 cites W2793751474 @default.
- W4281569242 cites W2894865807 @default.
- W4281569242 cites W2895645365 @default.
- W4281569242 cites W2904185271 @default.
- W4281569242 cites W2955918581 @default.
- W4281569242 cites W2962396447 @default.
- W4281569242 cites W2964995646 @default.
- W4281569242 cites W2979638528 @default.
- W4281569242 cites W2989875337 @default.
- W4281569242 cites W3007425433 @default.
- W4281569242 cites W3109914580 @default.
- W4281569242 cites W3165490951 @default.
- W4281569242 cites W4220824022 @default.
- W4281569242 cites W4243130812 @default.
- W4281569242 cites W972583108 @default.
- W4281569242 doi "https://doi.org/10.1126/science.abl6773" @default.
- W4281569242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35617374" @default.
- W4281569242 hasPublicationYear "2022" @default.
- W4281569242 type Work @default.
- W4281569242 citedByCount "29" @default.
- W4281569242 countsByYear W42815692422022 @default.
- W4281569242 countsByYear W42815692422023 @default.
- W4281569242 crossrefType "journal-article" @default.
- W4281569242 hasAuthorship W4281569242A5001518887 @default.
- W4281569242 hasAuthorship W4281569242A5004685940 @default.
- W4281569242 hasAuthorship W4281569242A5005776897 @default.
- W4281569242 hasAuthorship W4281569242A5008683790 @default.
- W4281569242 hasAuthorship W4281569242A5009011998 @default.
- W4281569242 hasAuthorship W4281569242A5014486667 @default.
- W4281569242 hasAuthorship W4281569242A5017328884 @default.
- W4281569242 hasAuthorship W4281569242A5017383692 @default.
- W4281569242 hasAuthorship W4281569242A5023021185 @default.
- W4281569242 hasAuthorship W4281569242A5032853383 @default.
- W4281569242 hasAuthorship W4281569242A5037541410 @default.
- W4281569242 hasAuthorship W4281569242A5038502044 @default.
- W4281569242 hasAuthorship W4281569242A5041185154 @default.
- W4281569242 hasAuthorship W4281569242A5041473246 @default.
- W4281569242 hasAuthorship W4281569242A5047306210 @default.
- W4281569242 hasAuthorship W4281569242A5052015413 @default.
- W4281569242 hasAuthorship W4281569242A5052557530 @default.
- W4281569242 hasAuthorship W4281569242A5053795308 @default.