Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281569294> ?p ?o ?g. }
- W4281569294 abstract "Abstract 1,3‐ trans ‐Disubstituted tetrahydroisoquinoline (THIQ) is a common heterocyclic structural unit of naphthylisoquinoline alkaloids. The assembly of this structural unit is not trivial, which constitutes a substantial challenge in the total synthesis of naphthylisoquinoline alkaloids and related pharmaceuticals. Herein, we report a modular and convergent method for the rapid assembly of 1,3‐ trans ‐disubstituted THIQ frameworks through a three‐component Catellani reaction and a Au I ‐catalyzed cyclization/reduction cascade. With widely available simple aryl iodides, aziridines and (triisopropylsilyl)acetylene as the building blocks, this method paves a practical way for the diversity‐oriented synthesis of 1,3‐ trans ‐disubstituted THIQs. Based on this new method, concise syntheses of an analogue of the new drug mevidalen and four naphthylisoquinoline alkaloids have been accomplished, demonstrating the broad synthetic utility of this approach." @default.
- W4281569294 created "2022-05-27" @default.
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- W4281569294 date "2022-06-17" @default.
- W4281569294 modified "2023-10-18" @default.
- W4281569294 title "A Modular Approach for Diversity‐Oriented Synthesis of 1,3‐<i>trans</i>‐Disubstituted Tetrahydroisoquinolines: Seven‐Step Asymmetric Synthesis of Michellamines B and C" @default.
- W4281569294 cites W1721673847 @default.
- W4281569294 cites W1968623468 @default.
- W4281569294 cites W1979015895 @default.
- W4281569294 cites W1985897849 @default.
- W4281569294 cites W1989772178 @default.
- W4281569294 cites W1997257311 @default.
- W4281569294 cites W2000299083 @default.
- W4281569294 cites W2000484552 @default.
- W4281569294 cites W2000491586 @default.
- W4281569294 cites W2003977701 @default.
- W4281569294 cites W2004867175 @default.
- W4281569294 cites W2005321159 @default.
- W4281569294 cites W2006231479 @default.
- W4281569294 cites W2006764912 @default.
- W4281569294 cites W2010580563 @default.
- W4281569294 cites W2014143880 @default.
- W4281569294 cites W2018146879 @default.
- W4281569294 cites W2020919534 @default.
- W4281569294 cites W2047643366 @default.
- W4281569294 cites W2048994453 @default.
- W4281569294 cites W2050848666 @default.
- W4281569294 cites W2051061316 @default.
- W4281569294 cites W2052964041 @default.
- W4281569294 cites W2053666931 @default.
- W4281569294 cites W2054691369 @default.
- W4281569294 cites W2054738303 @default.
- W4281569294 cites W2063080241 @default.
- W4281569294 cites W2063544580 @default.
- W4281569294 cites W2064881372 @default.
- W4281569294 cites W2066226964 @default.
- W4281569294 cites W2069427156 @default.
- W4281569294 cites W2086258617 @default.
- W4281569294 cites W2087035383 @default.
- W4281569294 cites W2095335734 @default.
- W4281569294 cites W2100678901 @default.
- W4281569294 cites W2121970136 @default.
- W4281569294 cites W2123581639 @default.
- W4281569294 cites W2140187528 @default.
- W4281569294 cites W2147744585 @default.
- W4281569294 cites W2152801082 @default.
- W4281569294 cites W2153738509 @default.
- W4281569294 cites W2161243905 @default.
- W4281569294 cites W2167235593 @default.
- W4281569294 cites W2320197145 @default.
- W4281569294 cites W2465616692 @default.
- W4281569294 cites W2470267586 @default.
- W4281569294 cites W2800117630 @default.
- W4281569294 cites W2811513220 @default.
- W4281569294 cites W2890456344 @default.
- W4281569294 cites W2895566609 @default.
- W4281569294 cites W2907065590 @default.
- W4281569294 cites W2923571840 @default.
- W4281569294 cites W2946975815 @default.
- W4281569294 cites W2950853764 @default.
- W4281569294 cites W2951324763 @default.
- W4281569294 cites W2951678665 @default.
- W4281569294 cites W2952391693 @default.
- W4281569294 cites W2952943679 @default.
- W4281569294 cites W2954186924 @default.
- W4281569294 cites W2972130034 @default.
- W4281569294 cites W3026749135 @default.
- W4281569294 cites W3084437808 @default.
- W4281569294 cites W3088226650 @default.
- W4281569294 cites W3109826361 @default.
- W4281569294 cites W3125169647 @default.
- W4281569294 cites W4200196174 @default.
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- W4281569294 doi "https://doi.org/10.1002/anie.202205245" @default.
- W4281569294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35616270" @default.
- W4281569294 hasPublicationYear "2022" @default.
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