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- W4281569328 abstract "p73, a p53 family member, undergoes alternative splicing at the 3′ end to produce multiple isoforms, but their expression and activity are largely unknown. Thus, CRISPR was used to knock out exon 12 (E12) in human cancer cell lines and mice, leading to isoform switch from p73α to isoform p73α1. We found that p73α1 is naturally expressed and induced by DNA damage. We also found that knockout of E12 suppresses cell growth and migration in H1299 and MIA PaCa-2 cells and promotes cellular senescence in mouse embryonic fibroblasts. Similarly, ectopic expression of p73α1 suppresses cell proliferation, whereas knockdown of p73α1 restores the cell proliferative and migratory capacities of E12−/− cells. Consistently, we found that E12+/− mice are not prone to spontaneous tumors. Instead, E12+/− mice are prone to systemic inflammation and exhibit elevated TNFα expression in inflamed tissues. Moreover, we found that Notch1, a master regulator of the inflammatory response, is regulated by p73α1 and highly expressed in E12−/− cells and inflamed E12+/− mouse tissues. Furthermore, through knockdown of p73α1 and/or Notch1 in E12−/− cells, we found that Notch1 is necessary for p73α1-mediated growth suppression. Together, these data suggest that p73α1 plays a critical role in tumor suppression and the inflammatory response via Notch1." @default.
- W4281569328 created "2022-05-27" @default.
- W4281569328 creator A5002191937 @default.
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- W4281569328 date "2022-05-26" @default.
- W4281569328 modified "2023-10-01" @default.
- W4281569328 title "p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1" @default.
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- W4281569328 doi "https://doi.org/10.1073/pnas.2123202119" @default.
- W4281569328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35617425" @default.
- W4281569328 hasPublicationYear "2022" @default.
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