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• W4281569393 endingPage "175" @default.
• W4281569393 startingPage "168" @default.
• W4281569393 abstract "Far-UVC radiation, typically defined as 200-235 nm, has similar or greater anti-microbial efficacy compared with conventional 254-nm germicidal radiation. In addition, biophysical considerations of the interaction of far-UVC with tissue, as well as multiple short-term safety studies in animal models and humans, suggest that far-UVC exposure may be safe for skin and eye tissue. Nevertheless, the potential for skin cancer after chronic long-term exposure to far-UVC has not been studied. Here, we assessed far-UVC induced carcinogenic skin changes and other pathological dermal abnormalities in 96 SKH-1 hairless mice of both sexes that were exposed to average daily dorsal skin doses of 400, 130 or 55 mJ cm-2 of 222 nm far-UVC radiation for 66 weeks, 5 days per week, 8 h per day, as well as similarly-treated unexposed controls. No evidence for increased skin cancer, abnormal skin growths or incidental skin pathology findings was observed in the far-UVC-exposed mice. In addition, there were no significant changes in morbidity or mortality. The findings from this study support the long-term safety of long-term chronic exposure to far-UVC radiation, and therefore its potential suitability as a practical anti-microbial approach to reduce airborne viral and bacterial loads in occupied indoor settings." @default.
• W4281569393 created "2022-05-27" @default.
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• W4281569393 date "2022-06-08" @default.
• W4281569393 modified "2023-10-16" @default.
• W4281569393 title "No Evidence of Induced Skin Cancer or Other Skin Abnormalities after Long‐Term (66 week) Chronic Exposure to 222‐nm <scp>Far‐UVC</scp> Radiation" @default.
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• W4281569393 doi "https://doi.org/10.1111/php.13656" @default.
• W4281569393 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35614842" @default.
• W4281569393 hasPublicationYear "2022" @default.
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