Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281569605> ?p ?o ?g. }
- W4281569605 endingPage "1223" @default.
- W4281569605 startingPage "1212" @default.
- W4281569605 abstract "The treatment landscape of acute myeloid leukemia (AML) is evolving, with promising therapies entering clinical translation, yet patient responses remain heterogeneous, and biomarkers for tailoring treatment are lacking. To understand how disease heterogeneity links with therapy response, we determined the leukemia cell hierarchy makeup from bulk transcriptomes of more than 1,000 patients through deconvolution using single-cell reference profiles of leukemia stem, progenitor and mature cell types. Leukemia hierarchy composition was associated with functional, genomic and clinical properties and converged into four overall classes, spanning Primitive, Mature, GMP and Intermediate. Critically, variation in hierarchy composition along the Primitive versus GMP or Primitive versus Mature axes were associated with response to chemotherapy or drug sensitivity profiles of targeted therapies, respectively. A seven-gene biomarker derived from the Primitive versus Mature axis was associated with response to 105 investigational drugs. Cellular hierarchy composition constitutes a novel framework for understanding disease biology and advancing precision medicine in AML. A novel gene expression classifier of AML heterogeneity captures patient-specific variation in leukemia cell composition and predicts clinical responses to treatment." @default.
- W4281569605 created "2022-05-27" @default.
- W4281569605 creator A5000436961 @default.
- W4281569605 creator A5013483392 @default.
- W4281569605 creator A5017956113 @default.
- W4281569605 creator A5018416096 @default.
- W4281569605 creator A5023623204 @default.
- W4281569605 creator A5026397928 @default.
- W4281569605 creator A5031785087 @default.
- W4281569605 creator A5035605515 @default.
- W4281569605 creator A5042576332 @default.
- W4281569605 creator A5048739197 @default.
- W4281569605 creator A5066043620 @default.
- W4281569605 creator A5068440044 @default.
- W4281569605 creator A5074167760 @default.
- W4281569605 creator A5074807429 @default.
- W4281569605 creator A5077339582 @default.
- W4281569605 creator A5079872301 @default.
- W4281569605 creator A5080227719 @default.
- W4281569605 creator A5086539748 @default.
- W4281569605 creator A5090356933 @default.
- W4281569605 date "2022-05-26" @default.
- W4281569605 modified "2023-10-15" @default.
- W4281569605 title "A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia" @default.
- W4281569605 cites W1255676896 @default.
- W4281569605 cites W1522482495 @default.
- W4281569605 cites W1530800565 @default.
- W4281569605 cites W174442591 @default.
- W4281569605 cites W1952112347 @default.
- W4281569605 cites W1967358345 @default.
- W4281569605 cites W1996870623 @default.
- W4281569605 cites W1999687329 @default.
- W4281569605 cites W2002213310 @default.
- W4281569605 cites W2004878973 @default.
- W4281569605 cites W2009886857 @default.
- W4281569605 cites W2019199359 @default.
- W4281569605 cites W2048385227 @default.
- W4281569605 cites W2087734794 @default.
- W4281569605 cites W2090431728 @default.
- W4281569605 cites W2090982381 @default.
- W4281569605 cites W2103546044 @default.
- W4281569605 cites W2107665951 @default.
- W4281569605 cites W2111874706 @default.
- W4281569605 cites W2137881702 @default.
- W4281569605 cites W2146512944 @default.
- W4281569605 cites W2150690129 @default.
- W4281569605 cites W2179438025 @default.
- W4281569605 cites W2261541794 @default.
- W4281569605 cites W2266841241 @default.
- W4281569605 cites W2266967112 @default.
- W4281569605 cites W2337848504 @default.
- W4281569605 cites W2343956310 @default.
- W4281569605 cites W2404379313 @default.
- W4281569605 cites W2419140434 @default.
- W4281569605 cites W2426586472 @default.
- W4281569605 cites W2471542144 @default.
- W4281569605 cites W2551783467 @default.
- W4281569605 cites W2560012305 @default.
- W4281569605 cites W2616922646 @default.
- W4281569605 cites W2730666287 @default.
- W4281569605 cites W2773514102 @default.
- W4281569605 cites W2777794149 @default.
- W4281569605 cites W2785792383 @default.
- W4281569605 cites W2800392236 @default.
- W4281569605 cites W2884841488 @default.
- W4281569605 cites W2886748809 @default.
- W4281569605 cites W2890477656 @default.
- W4281569605 cites W2896480326 @default.
- W4281569605 cites W2898648224 @default.
- W4281569605 cites W2916458303 @default.
- W4281569605 cites W2940559873 @default.
- W4281569605 cites W2942610007 @default.
- W4281569605 cites W2943554095 @default.
- W4281569605 cites W2966569571 @default.
- W4281569605 cites W2971793138 @default.
- W4281569605 cites W2974775294 @default.
- W4281569605 cites W2980344383 @default.
- W4281569605 cites W2981952148 @default.
- W4281569605 cites W3006606775 @default.
- W4281569605 cites W3036206386 @default.
- W4281569605 cites W3044387220 @default.
- W4281569605 cites W3089241551 @default.
- W4281569605 cites W3096036460 @default.
- W4281569605 cites W3100577837 @default.
- W4281569605 cites W3106188259 @default.
- W4281569605 cites W3108186512 @default.
- W4281569605 cites W3121168830 @default.
- W4281569605 cites W3158922343 @default.
- W4281569605 cites W3196650609 @default.
- W4281569605 cites W3206235705 @default.
- W4281569605 cites W4200019298 @default.
- W4281569605 cites W4252030004 @default.
- W4281569605 doi "https://doi.org/10.1038/s41591-022-01819-x" @default.
- W4281569605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35618837" @default.
- W4281569605 hasPublicationYear "2022" @default.
- W4281569605 type Work @default.
- W4281569605 citedByCount "63" @default.
- W4281569605 countsByYear W42815696052022 @default.