FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281569774> ?p ?o ?g. }

• W4281569774 endingPage "3912" @default.
• W4281569774 startingPage "3904" @default.
• W4281569774 abstract "Abstract Calcium channel blockers (CCBs) differ in their ability to penetrate into the brain. Pharmacoepidemiological studies suggest that CCBs as a class may have beneficial effects on the risks and outcomes of some psychiatric and neurological disorders. It is plausible but unknown whether this effect relates to their brain penetrance. To address this, we used the TriNetX electronic health records network to identify people prescribed a brain-penetrant CCB (BP-CCB), or those given amlodipine, a CCB with low brain penetrability. We created cohorts of patients who, prior to first CCB exposure, either had to have, or could not have had, a recorded ICD-10 diagnosis in any of the following categories: psychotic disorder; affective disorder (including bipolar disorder and major depressive disorder); anxiety disorder; substance use disorder; sleep disorder; delirium; dementia, or movement disorder. Cohort pairs were propensity score matched for age, sex, race, blood pressure, body mass index, and a range of other variables. The outcomes were the incidence of these disorders measured over a two-year exposure period. Matched cohort sizes ranged from 17,896 to 49,987. In people with no prior history of psychiatric or neurodegenerative disorder, there was a significantly lower incidence of most disorders with BP-CCBs compared to amlodipine, with risk ratios ranging from 0.64 to 0.88 and an overall risk ratio of 0.88, i.e. a risk reduction of 12%. In people who did have a prior psychiatric or neurodegenerative diagnosis, differences were much smaller, but again showed lower risks for several disorders with BP-CCBs compared to amlodipine. The differences were somewhat more marked in women and in people less than 60 years old. Results were similar when comparing BP-CCBs with verapamil and diltiazem. We also compared BP-CCBs with angiotensin receptor blockers, and found an overall risk ratio of 0.94 in favour of BP-CCBs, but with differential effects across disorders including a higher risk of psychotic disorder and dementia, but a lower risk for anxiety and sleep disorders. In some analyses, there was evidence of residual confounding even after the extensive matching, in that negative control outcomes showed a reduced incidence with BP-CCBs relative to the comparator cohort. In summary, CCBs that readily penetrate the brain are associated with a lower incidence of neuropsychiatric disorders, especially first diagnoses, compared to CCBs which do not. This may reflect their blockade of neuronal voltage-gated calcium channels. The findings encourage repurposing trials using existing BP-CCBs, and suggest that novel BP-CCBs with enhanced and more selective central actions might have greater therapeutic potential for psychiatric and neurodegenerative disorders." @default.
• W4281569774 created "2022-05-27" @default.
• W4281569774 creator A5042594688 @default.
• W4281569774 creator A5050681797 @default.
• W4281569774 date "2022-05-26" @default.
• W4281569774 modified "2023-10-16" @default.
• W4281569774 title "Brain-penetrant calcium channel blockers are associated with a reduced incidence of neuropsychiatric disorders" @default.
• W4281569774 cites W1565992055 @default.
• W4281569774 cites W1761464837 @default.
• W4281569774 cites W184602233 @default.
• W4281569774 cites W1921440755 @default.
• W4281569774 cites W1973824341 @default.
• W4281569774 cites W1978032472 @default.
• W4281569774 cites W1978473122 @default.
• W4281569774 cites W1984272164 @default.
• W4281569774 cites W1987977850 @default.
• W4281569774 cites W1988137843 @default.
• W4281569774 cites W1991137238 @default.
• W4281569774 cites W2009428399 @default.
• W4281569774 cites W2022846150 @default.
• W4281569774 cites W2036193982 @default.
• W4281569774 cites W2039870867 @default.
• W4281569774 cites W2040684710 @default.
• W4281569774 cites W2045529054 @default.
• W4281569774 cites W2046525566 @default.
• W4281569774 cites W2048445986 @default.
• W4281569774 cites W2051044968 @default.
• W4281569774 cites W2057932313 @default.
• W4281569774 cites W2058991248 @default.
• W4281569774 cites W2061635565 @default.
• W4281569774 cites W2062296106 @default.
• W4281569774 cites W2064585904 @default.
• W4281569774 cites W2076393535 @default.
• W4281569774 cites W2077932410 @default.
• W4281569774 cites W2081024670 @default.
• W4281569774 cites W2084650733 @default.
• W4281569774 cites W2086553635 @default.
• W4281569774 cites W2093288418 @default.
• W4281569774 cites W2099663618 @default.
• W4281569774 cites W2140302476 @default.
• W4281569774 cites W2144638913 @default.
• W4281569774 cites W2163172571 @default.
• W4281569774 cites W2174438801 @default.
• W4281569774 cites W2187921174 @default.
• W4281569774 cites W2258472936 @default.
• W4281569774 cites W2324185390 @default.
• W4281569774 cites W2324980061 @default.
• W4281569774 cites W2412736822 @default.
• W4281569774 cites W2491603413 @default.
• W4281569774 cites W2517388783 @default.
• W4281569774 cites W2532329074 @default.
• W4281569774 cites W2565763095 @default.
• W4281569774 cites W2623805123 @default.
• W4281569774 cites W2791138970 @default.
• W4281569774 cites W2799558871 @default.
• W4281569774 cites W2890095647 @default.
• W4281569774 cites W2904173757 @default.
• W4281569774 cites W2909287823 @default.
• W4281569774 cites W2910557287 @default.
• W4281569774 cites W2913891161 @default.
• W4281569774 cites W2922119122 @default.
• W4281569774 cites W2954967623 @default.
• W4281569774 cites W2965008065 @default.
• W4281569774 cites W2969987084 @default.
• W4281569774 cites W2977618246 @default.
• W4281569774 cites W2984201353 @default.
• W4281569774 cites W2984556359 @default.
• W4281569774 cites W2989576931 @default.
• W4281569774 cites W3001146460 @default.
• W4281569774 cites W3003357216 @default.
• W4281569774 cites W3027282093 @default.
• W4281569774 cites W3032852804 @default.
• W4281569774 cites W3049757613 @default.
• W4281569774 cites W3080791429 @default.
• W4281569774 cites W3087694789 @default.
• W4281569774 cites W3087816303 @default.
• W4281569774 cites W3096628704 @default.
• W4281569774 cites W3120460959 @default.
• W4281569774 cites W3129177568 @default.
• W4281569774 cites W3165249978 @default.
• W4281569774 cites W3173296566 @default.
• W4281569774 cites W3184855083 @default.
• W4281569774 cites W3202014360 @default.
• W4281569774 cites W4213300229 @default.
• W4281569774 cites W4214893974 @default.
• W4281569774 doi "https://doi.org/10.1038/s41380-022-01615-6" @default.
• W4281569774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35618884" @default.
• W4281569774 hasPublicationYear "2022" @default.
• W4281569774 type Work @default.
• W4281569774 citedByCount "12" @default.
• W4281569774 countsByYear W42815697742022 @default.
• W4281569774 countsByYear W42815697742023 @default.
• W4281569774 crossrefType "journal-article" @default.
• W4281569774 hasAuthorship W4281569774A5042594688 @default.
• W4281569774 hasAuthorship W4281569774A5050681797 @default.
• W4281569774 hasBestOaLocation W42815697741 @default.
• W4281569774 hasConcept C118552586 @default.
• W4281569774 hasConcept C126322002 @default.

• next