FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281570315> ?p ?o ?g. }

• W4281570315 abstract "Abstract Over the course of the pandemic variants have arisen at a steady rate. The most recent variants to emerge, BA.4 and BA.5, form part of the Omicron lineage and were first found in Southern Africa where they are driving the current wave of infection. In this report, we perform an in-depth characterisation of the antigenicity of the BA.4/BA.5 Spike protein by comparing sera collected post-vaccination, post-BA.1 or BA.2 infection, or post breakthrough infection of vaccinated individuals with the Omicron variant. In addition, we assess sensitivity to neutralisation by commonly used therapeutic monoclonal antibodies. We find sera collected post-vaccination have a similar ability to neutralise BA.1, BA.2 and BA.4/BA.5. In contrast, in the absence of vaccination, prior infection with BA.2 or, in particular, BA.1 results in an antibody response that neutralises BA.4/BA.5 poorly. Breakthrough infection with Omicron in vaccinees leads to a broad neutralising response against the new variants. The sensitivity of BA.4/BA.5 to neutralisation by therapeutic monoclonal antibodies was similar to that of BA.2. These data suggest BA.4/BA.5 are antigenically distinct from BA.1 and, to a lesser extent, BA.2. The enhanced breadth of neutralisation observed following breakthrough infection with Omicron suggests that vaccination with heterologous or multivalent antigens may represent viable strategies for the development of cross-neutralising antibody responses." @default.
• W4281570315 created "2022-05-27" @default.
• W4281570315 creator A5001065613 @default.
• W4281570315 creator A5003947542 @default.
• W4281570315 creator A5008173791 @default.
• W4281570315 creator A5011256041 @default.
• W4281570315 creator A5018812698 @default.
• W4281570315 creator A5026122068 @default.
• W4281570315 creator A5038353299 @default.
• W4281570315 creator A5039597988 @default.
• W4281570315 creator A5043430899 @default.
• W4281570315 creator A5047459331 @default.
• W4281570315 creator A5049164866 @default.
• W4281570315 creator A5050947572 @default.
• W4281570315 creator A5062484897 @default.
• W4281570315 creator A5064630106 @default.
• W4281570315 creator A5065015563 @default.
• W4281570315 creator A5065357829 @default.
• W4281570315 creator A5065830204 @default.
• W4281570315 creator A5081350583 @default.
• W4281570315 creator A5086105625 @default.
• W4281570315 creator A5090243414 @default.
• W4281570315 creator A5091639782 @default.
• W4281570315 date "2022-05-25" @default.
• W4281570315 modified "2023-10-02" @default.
• W4281570315 title "Distinct antigenic properties of the SARS-CoV-2 Omicron lineages BA.4 and BA.5" @default.
• W4281570315 cites W3093667122 @default.
• W4281570315 cites W3127852352 @default.
• W4281570315 cites W3204711087 @default.
• W4281570315 cites W3206174010 @default.
• W4281570315 cites W4200276709 @default.
• W4281570315 cites W4214657299 @default.
• W4281570315 cites W4220673385 @default.
• W4281570315 cites W4225312017 @default.
• W4281570315 cites W4225369388 @default.
• W4281570315 cites W4225407677 @default.
• W4281570315 cites W4226491433 @default.
• W4281570315 cites W4281294447 @default.
• W4281570315 cites W4281388838 @default.
• W4281570315 cites W4281389436 @default.
• W4281570315 doi "https://doi.org/10.1101/2022.05.25.493397" @default.
• W4281570315 hasPublicationYear "2022" @default.
• W4281570315 type Work @default.
• W4281570315 citedByCount "10" @default.
• W4281570315 countsByYear W42815703152022 @default.
• W4281570315 countsByYear W42815703152023 @default.
• W4281570315 crossrefType "posted-content" @default.
• W4281570315 hasAuthorship W4281570315A5001065613 @default.
• W4281570315 hasAuthorship W4281570315A5003947542 @default.
• W4281570315 hasAuthorship W4281570315A5008173791 @default.
• W4281570315 hasAuthorship W4281570315A5011256041 @default.
• W4281570315 hasAuthorship W4281570315A5018812698 @default.
• W4281570315 hasAuthorship W4281570315A5026122068 @default.
• W4281570315 hasAuthorship W4281570315A5038353299 @default.
• W4281570315 hasAuthorship W4281570315A5039597988 @default.
• W4281570315 hasAuthorship W4281570315A5043430899 @default.
• W4281570315 hasAuthorship W4281570315A5047459331 @default.
• W4281570315 hasAuthorship W4281570315A5049164866 @default.
• W4281570315 hasAuthorship W4281570315A5050947572 @default.
• W4281570315 hasAuthorship W4281570315A5062484897 @default.
• W4281570315 hasAuthorship W4281570315A5064630106 @default.
• W4281570315 hasAuthorship W4281570315A5065015563 @default.
• W4281570315 hasAuthorship W4281570315A5065357829 @default.
• W4281570315 hasAuthorship W4281570315A5065830204 @default.
• W4281570315 hasAuthorship W4281570315A5081350583 @default.
• W4281570315 hasAuthorship W4281570315A5086105625 @default.
• W4281570315 hasAuthorship W4281570315A5090243414 @default.
• W4281570315 hasAuthorship W4281570315A5091639782 @default.
• W4281570315 hasBestOaLocation W42815703151 @default.
• W4281570315 hasConcept C104317684 @default.
• W4281570315 hasConcept C14086860 @default.
• W4281570315 hasConcept C142724271 @default.
• W4281570315 hasConcept C147483822 @default.
• W4281570315 hasConcept C159047783 @default.
• W4281570315 hasConcept C159654299 @default.
• W4281570315 hasConcept C203014093 @default.
• W4281570315 hasConcept C22070199 @default.
• W4281570315 hasConcept C2779026604 @default.
• W4281570315 hasConcept C2779134260 @default.
• W4281570315 hasConcept C2780115692 @default.
• W4281570315 hasConcept C3008058167 @default.
• W4281570315 hasConcept C524204448 @default.
• W4281570315 hasConcept C542903549 @default.
• W4281570315 hasConcept C54355233 @default.
• W4281570315 hasConcept C71924100 @default.
• W4281570315 hasConcept C86803240 @default.
• W4281570315 hasConceptScore W4281570315C104317684 @default.
• W4281570315 hasConceptScore W4281570315C14086860 @default.
• W4281570315 hasConceptScore W4281570315C142724271 @default.
• W4281570315 hasConceptScore W4281570315C147483822 @default.
• W4281570315 hasConceptScore W4281570315C159047783 @default.
• W4281570315 hasConceptScore W4281570315C159654299 @default.
• W4281570315 hasConceptScore W4281570315C203014093 @default.
• W4281570315 hasConceptScore W4281570315C22070199 @default.
• W4281570315 hasConceptScore W4281570315C2779026604 @default.
• W4281570315 hasConceptScore W4281570315C2779134260 @default.
• W4281570315 hasConceptScore W4281570315C2780115692 @default.
• W4281570315 hasConceptScore W4281570315C3008058167 @default.
• W4281570315 hasConceptScore W4281570315C524204448 @default.
• W4281570315 hasConceptScore W4281570315C542903549 @default.

• next