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- W4281570358 abstract "Significance DNA functions in living cells are crucially affected by the three-dimensional genome structure and dynamics. We analyze the whole genome of human cells by developing a polymer model of interphase nuclei. The model reveals the essential importance of the unfolding process of chromosomes from the condensed mitotic state for describing the interphase nuclei; through the unfolding process, heterogeneous repulsive interactions among chromatin chains induce phase separation of chromatin, which quantitatively explains the experimentally observed various genomic data. We can use this model structure as a platform to analyze the relationship among genome structure, dynamics, and functions." @default.
- W4281570358 created "2022-05-27" @default.
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- W4281570358 date "2022-05-26" @default.
- W4281570358 modified "2023-10-18" @default.
- W4281570358 title "Generation of dynamic three-dimensional genome structure through phase separation of chromatin" @default.
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- W4281570358 doi "https://doi.org/10.1073/pnas.2109838119" @default.
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