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- W4281570986 abstract "Inflammasomes are cytosolic protein complexes that form in response to pathogen or damage signals and initiate inflammation. Signal transduction in the inflammasome pathway occurs via protein-protein interaction, protein conformational change, and oligomerization. Recent advances in structural biology have provided multiple insights in inflammasome regulation that are both biologically intriguing and therapeutically valuable. In this review, we summarize the current understanding of three most studied inflammasome complexes: the NAIP/NLRC4, NLRP1, and NLRP3 inflammasomes. We discuss the general mechanisms and unique features of their regulation and how investigating these systems may contribute to therapeutic applications." @default.
- W4281570986 created "2022-05-27" @default.
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- W4281570986 date "2022-08-01" @default.
- W4281570986 modified "2023-09-26" @default.
- W4281570986 title "Structural mechanisms of inflammasome regulation revealed by cryo-EM studies" @default.
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- W4281570986 doi "https://doi.org/10.1016/j.sbi.2022.102390" @default.
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