FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281571259> ?p ?o ?g. }

• W4281571259 endingPage "3109.e15" @default.
• W4281571259 startingPage "3093" @default.
• W4281571259 abstract "Because burn injuries are often followed by a derailed immune response and excessive inflammation, a thorough understanding of the occurring reactions is key to preventing secondary complications. This systematic review, which includes 247 animal studies, shows the postburn response of 14 different immune cell types involved in immediate and long-term effects in both wound tissue and circulation. Peripheral blood neutrophil and monocyte numbers increased directly after burns, whereas thrombocyte numbers increased near the end of the first week. However, lymphocyte numbers were decreased for at least 2 weeks. In burn wound tissue, neutrophil and macrophage numbers accumulated during the first 3 weeks. Burns also altered cellular functions because we found an increased migratory potential of leukocytes, impaired antibacterial activity of neutrophils, and enhanced inflammatory mediator production by macrophages. Neutrophil surges were positively associated with burn size and were highest in rats. Altogether, this comprehensive overview of the temporal immune cell dynamics shows that unlike normal wound healing, burn injury induces a long-lasting inflammatory response. It provides a fundamental research basis to improve experimental set-ups, burn care, and outcomes. Because burn injuries are often followed by a derailed immune response and excessive inflammation, a thorough understanding of the occurring reactions is key to preventing secondary complications. This systematic review, which includes 247 animal studies, shows the postburn response of 14 different immune cell types involved in immediate and long-term effects in both wound tissue and circulation. Peripheral blood neutrophil and monocyte numbers increased directly after burns, whereas thrombocyte numbers increased near the end of the first week. However, lymphocyte numbers were decreased for at least 2 weeks. In burn wound tissue, neutrophil and macrophage numbers accumulated during the first 3 weeks. Burns also altered cellular functions because we found an increased migratory potential of leukocytes, impaired antibacterial activity of neutrophils, and enhanced inflammatory mediator production by macrophages. Neutrophil surges were positively associated with burn size and were highest in rats. Altogether, this comprehensive overview of the temporal immune cell dynamics shows that unlike normal wound healing, burn injury induces a long-lasting inflammatory response. It provides a fundamental research basis to improve experimental set-ups, burn care, and outcomes." @default.
• W4281571259 created "2022-05-27" @default.
• W4281571259 creator A5010059618 @default.
• W4281571259 creator A5011563552 @default.
• W4281571259 creator A5017249574 @default.
• W4281571259 creator A5028653276 @default.
• W4281571259 creator A5052693979 @default.
• W4281571259 creator A5091210869 @default.
• W4281571259 date "2022-11-01" @default.
• W4281571259 modified "2023-10-16" @default.
• W4281571259 title "Burn-Induced Local and Systemic Immune Response: Systematic Review and Meta-Analysis of Animal Studies" @default.
• W4281571259 cites W1486491241 @default.
• W4281571259 cites W1513693864 @default.
• W4281571259 cites W1537640961 @default.
• W4281571259 cites W1583375549 @default.
• W4281571259 cites W1594751854 @default.
• W4281571259 cites W159887038 @default.
• W4281571259 cites W1605913315 @default.
• W4281571259 cites W179291766 @default.
• W4281571259 cites W1922526906 @default.
• W4281571259 cites W1929903403 @default.
• W4281571259 cites W1964207919 @default.
• W4281571259 cites W1968457732 @default.
• W4281571259 cites W1969668693 @default.
• W4281571259 cites W1970608960 @default.
• W4281571259 cites W1971474536 @default.
• W4281571259 cites W1971532757 @default.
• W4281571259 cites W1973826631 @default.
• W4281571259 cites W1975911151 @default.
• W4281571259 cites W1977047789 @default.
• W4281571259 cites W1977445496 @default.
• W4281571259 cites W1978548090 @default.
• W4281571259 cites W1980503050 @default.
• W4281571259 cites W1980914250 @default.
• W4281571259 cites W1981247717 @default.
• W4281571259 cites W1981784624 @default.
• W4281571259 cites W1982662898 @default.
• W4281571259 cites W1983984331 @default.
• W4281571259 cites W1984747276 @default.
• W4281571259 cites W1984997878 @default.
• W4281571259 cites W1985092258 @default.
• W4281571259 cites W1985167082 @default.
• W4281571259 cites W1985911774 @default.
• W4281571259 cites W1986883069 @default.
• W4281571259 cites W1987688088 @default.
• W4281571259 cites W1991117128 @default.
• W4281571259 cites W1991789911 @default.
• W4281571259 cites W1992702451 @default.
• W4281571259 cites W1994298028 @default.
• W4281571259 cites W1994393091 @default.
• W4281571259 cites W1997896661 @default.
• W4281571259 cites W1999693700 @default.
• W4281571259 cites W2000685330 @default.
• W4281571259 cites W2001194276 @default.
• W4281571259 cites W2001305146 @default.
• W4281571259 cites W2002430012 @default.
• W4281571259 cites W2003027976 @default.
• W4281571259 cites W2007229891 @default.
• W4281571259 cites W2007864254 @default.
• W4281571259 cites W2009537291 @default.
• W4281571259 cites W2009617509 @default.
• W4281571259 cites W2009939479 @default.
• W4281571259 cites W2010129331 @default.
• W4281571259 cites W2011703125 @default.
• W4281571259 cites W2013057090 @default.
• W4281571259 cites W2015193147 @default.
• W4281571259 cites W2019495560 @default.
• W4281571259 cites W2020888283 @default.
• W4281571259 cites W2023382663 @default.
• W4281571259 cites W2024759424 @default.
• W4281571259 cites W2025028553 @default.
• W4281571259 cites W2028365995 @default.
• W4281571259 cites W2029337488 @default.
• W4281571259 cites W2030351651 @default.
• W4281571259 cites W2031014053 @default.
• W4281571259 cites W2031136622 @default.
• W4281571259 cites W2032500924 @default.
• W4281571259 cites W2033439777 @default.
• W4281571259 cites W2034616636 @default.
• W4281571259 cites W2035035388 @default.
• W4281571259 cites W2037094879 @default.
• W4281571259 cites W2038427285 @default.
• W4281571259 cites W2038756210 @default.
• W4281571259 cites W2040252228 @default.
• W4281571259 cites W2040711815 @default.
• W4281571259 cites W2041122966 @default.
• W4281571259 cites W2044001014 @default.
• W4281571259 cites W2044321263 @default.
• W4281571259 cites W2044538506 @default.
• W4281571259 cites W2046301979 @default.
• W4281571259 cites W2047130591 @default.
• W4281571259 cites W2048629762 @default.
• W4281571259 cites W2050082053 @default.
• W4281571259 cites W2050087360 @default.
• W4281571259 cites W2050689917 @default.
• W4281571259 cites W2053218383 @default.
• W4281571259 cites W2053795936 @default.
• W4281571259 cites W2054681436 @default.

• next