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- W4281609743 abstract "Introduction The UK MS service audit builds upon GIRFT’s recommendation for disease-specific data. Here, we address MS disease modifying treatment (DMT) prescribing. Aim To document MS Teams’ DMT prescribing. Methods We asked all MS services to share their MS DMT prescribing for the 2018/2019 financial year. We computed: the proportion of people living with MS (PLwMS) on DMTs; drugs prescribed, ratios of higher- to-lower potency drugs, costs to the NHS. Results To date, 49/70 (70%) services have shared data (none declined our request). They treated >21,000 people with DMTs. The proportion of PLwMS on DMTs varied 5.5-fold (range=14.6% to 79.4%; mean=39%). Most services (34/49; 69%) had unrestricted prescribing. These services varied 5-fold (9% to 50%) in the proportion of people prescribed monoclonal antibodies (alemtuzumab, natalizumab, ocrelizumab). The total annual spend from 49 services exceeded £261 million (extrapolated to £373million from 70 services). Mean DMT spend/patient was £12,096 but varied 3.6-fold (£7,116 to £25,833). NHSE quote the total annual increase in DMT spend was 10% in 2019/2020. Conclusions DMT prescribing variations are expected, but important, if associated with differing outcomes. We recommend the substantial DMT spend and its increase, demands UK investment to: maximise processes (full data reporting to prescribers) and outcome measurement (including dashboard of longi- tudinal and peer-benchmark prescribing practice, eg induction vs escalation approaches and sequenc- ing) to provide optimal real world evidence to guide prescribing. Acknowledgements Neurology Academy david.rog@srft.nhs.uk 79" @default.
- W4281609743 created "2022-06-12" @default.
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- W4281609743 date "2022-05-27" @default.
- W4281609743 modified "2023-10-16" @default.
- W4281609743 title "108 UK multiple sclerosis service and DMT audit of 70 centres: variation in DMT prescribing" @default.
- W4281609743 doi "https://doi.org/10.1136/jnnp-2022-abn.433" @default.
- W4281609743 hasPublicationYear "2022" @default.
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