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- W4281610087 abstract "Circular RNAs (circRNAs) are endogenous, covalently circularised, non-protein-coding RNAs generated from back-splicing. Most circRNAs are very stable, highly conserved, and expressed in a tissue-, cell- and developmental stage-specific manner. circRNAs play a significant role in various biological processes, such as regulation of gene expression and protein translation via sponging of microRNAs and binding with RNA-binding proteins. circRNAs have become a topic of great interest in research due to their close link with the development of various diseases. Their high stability, conservation and abundance in body fluids make them promising biomarkers for many diseases. A growing body of evidence suggests that aberrant expression of circRNAs and their targets plays a crucial role in pulmonary vascular remodelling and pulmonary arterial hypertension (group 1) as well as other forms (groups 3 and 4) of pulmonary hypertension (PH). Here we discuss the roles and molecular mechanisms of circRNAs in the pathogenesis of pulmonary vascular remodelling and PH. We also highlight the therapeutic and biomarker potential of circRNAs in PH." @default.
- W4281610087 created "2022-06-12" @default.
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- W4281610087 date "2022-06-09" @default.
- W4281610087 modified "2023-09-26" @default.
- W4281610087 title "The role of circular RNAs in pulmonary hypertension" @default.
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- W4281610087 doi "https://doi.org/10.1183/13993003.00012-2022" @default.
- W4281610087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35680145" @default.
- W4281610087 hasPublicationYear "2022" @default.
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