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• W4281615407 endingPage "149" @default.
• W4281615407 startingPage "131" @default.
• W4281615407 abstract "Background: Flavonoids are a class of polyphenolic bioactive compounds obtained from plants, which have a wide range of chemical structures and properties. More than 9000 distinct flavonoid molecules have been identified, and have been found to regulate numerous developmental processes and play key biological roles in living organism. Objective: This review aims to highlight the hepatoprotective potentiality of flavonoids and co-relate their pharmacological activity with their chemical structure. Methods: With advancement in the field of research related to phytochemicals, it is evident that flavonoids have versatile health benefits, viz., antioxidant property, free radical scavenging capacity, anticancer activity. The basic structures are C6—C3—C6 rings with various substitution patterns, resulting in a succession of subclass compounds, and the relationships between chemical structures and bioactivity have previously been investigated. Results: The hepatoprotective effects of bioactive flavonoids derived from plants have been widely linked to their antioxidant activity, antiinflammatory activity, effects on sterol regulatory element-binding proteins (SREBP), peroxisome proliferator-activated receptor gamma (PPARγ) receptors, and inflammatory mediator cytokines according to numerous studies. The C2-C3 double bond at the A ring, as well as the hydroxyl groups of C3′or C4′, and the carbonyl group at position C4,have been shown to augment their hepatoprotective activities; however, hydroxymethylation at C3′ and C4′ has been found to diminish the hepatoprotective activity. Conclusion: The impact of flavonoid moieties and the structure-activity relationship of flavonoids related to combating various hepatic disorders have been vividly discussed in this review paper." @default.
• W4281615407 created "2022-06-12" @default.
• W4281615407 creator A5009879185 @default.
• W4281615407 creator A5031130860 @default.
• W4281615407 creator A5059468654 @default.
• W4281615407 creator A5075607999 @default.
• W4281615407 date "2023-02-01" @default.
• W4281615407 modified "2023-09-27" @default.
• W4281615407 title "An Insight into the Hepatoprotective Activity and Structure-activity Relationships of Flavonoids" @default.
• W4281615407 cites W1514732452 @default.
• W4281615407 cites W1565057930 @default.
• W4281615407 cites W1821077834 @default.
• W4281615407 cites W1964546362 @default.
• W4281615407 cites W1965006574 @default.
• W4281615407 cites W1965011260 @default.
• W4281615407 cites W1965641932 @default.
• W4281615407 cites W1966591496 @default.
• W4281615407 cites W1966820997 @default.
• W4281615407 cites W1967312447 @default.
• W4281615407 cites W1968215787 @default.
• W4281615407 cites W1971770400 @default.
• W4281615407 cites W1972019946 @default.
• W4281615407 cites W1972899454 @default.
• W4281615407 cites W1974254997 @default.
• W4281615407 cites W1977367026 @default.
• W4281615407 cites W1980998456 @default.
• W4281615407 cites W1981930609 @default.
• W4281615407 cites W1987349832 @default.
• W4281615407 cites W1987407807 @default.
• W4281615407 cites W1988853236 @default.
• W4281615407 cites W1990637866 @default.
• W4281615407 cites W1990857181 @default.
• W4281615407 cites W1991192434 @default.
• W4281615407 cites W1992382405 @default.
• W4281615407 cites W1993382405 @default.
• W4281615407 cites W1993588774 @default.
• W4281615407 cites W2001106467 @default.
• W4281615407 cites W2001876358 @default.
• W4281615407 cites W2006041438 @default.
• W4281615407 cites W2006815797 @default.
• W4281615407 cites W2009170266 @default.
• W4281615407 cites W2011812827 @default.
• W4281615407 cites W2017987427 @default.
• W4281615407 cites W2023904752 @default.
• W4281615407 cites W2031896371 @default.
• W4281615407 cites W2038053883 @default.
• W4281615407 cites W2038308614 @default.
• W4281615407 cites W2043309991 @default.
• W4281615407 cites W2052694803 @default.
• W4281615407 cites W2055020674 @default.
• W4281615407 cites W2056799623 @default.
• W4281615407 cites W2062274281 @default.
• W4281615407 cites W2064259694 @default.
• W4281615407 cites W2066857412 @default.
• W4281615407 cites W2068094120 @default.
• W4281615407 cites W2075330627 @default.
• W4281615407 cites W2079967727 @default.
• W4281615407 cites W2082142840 @default.
• W4281615407 cites W2082436014 @default.
• W4281615407 cites W2082765587 @default.
• W4281615407 cites W2082809972 @default.
• W4281615407 cites W2084110010 @default.
• W4281615407 cites W2085659241 @default.
• W4281615407 cites W2086505785 @default.
• W4281615407 cites W2087638306 @default.
• W4281615407 cites W2090319066 @default.
• W4281615407 cites W2091004712 @default.
• W4281615407 cites W2098620454 @default.
• W4281615407 cites W2106219242 @default.
• W4281615407 cites W2109932763 @default.
• W4281615407 cites W2111754392 @default.
• W4281615407 cites W2111923125 @default.
• W4281615407 cites W2114375715 @default.
• W4281615407 cites W2114886951 @default.
• W4281615407 cites W2116060738 @default.
• W4281615407 cites W2117790528 @default.
• W4281615407 cites W2119660698 @default.
• W4281615407 cites W2120591996 @default.
• W4281615407 cites W2120815008 @default.
• W4281615407 cites W2129205142 @default.
• W4281615407 cites W2134380580 @default.
• W4281615407 cites W2134705170 @default.
• W4281615407 cites W2134979720 @default.
• W4281615407 cites W2142095611 @default.
• W4281615407 cites W2144862608 @default.
• W4281615407 cites W2146479258 @default.
• W4281615407 cites W2154105843 @default.
• W4281615407 cites W2155309541 @default.
• W4281615407 cites W2155421014 @default.
• W4281615407 cites W2157565326 @default.
• W4281615407 cites W2159183335 @default.
• W4281615407 cites W2166026709 @default.
• W4281615407 cites W2166826446 @default.
• W4281615407 cites W2169410808 @default.
• W4281615407 cites W2171371398 @default.
• W4281615407 cites W2179744958 @default.
• W4281615407 cites W2204688218 @default.
• W4281615407 cites W2207463207 @default.

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