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• W4281617196 abstract "Interest in the lysosome's potential role in anticancer therapies has recently been appreciated in the field of immuno-oncology. Targeting lysosomes triggers apoptotic pathways, inhibits cytoprotective autophagy, and activates a unique form of apoptosis known as immunogenic cell death (ICD). This mechanism stimulates a local and systemic immune response against dead-cell antigens. Stressors that can lead to ICD include an abundance of ROS which induce lysosome membrane permeability (LMP). Dying cells express markers that activate immune cells. Dendritic cells engulf the dying cell and then present the cell's neoantigens to T cells. The discovery of ICD-inducing agents is important due to their potential to trigger autoimmunity. In this review, we discuss the various mechanisms of activating lysosome-induced cell death in cancer cells specifically and the strategies that current laboratories are using to selectively promote LMP in tumors." @default.
• W4281617196 created "2022-06-13" @default.
• W4281617196 creator A5010785810 @default.
• W4281617196 creator A5042926664 @default.
• W4281617196 creator A5083697988 @default.
• W4281617196 date "2022-05-30" @default.
• W4281617196 modified "2023-10-14" @default.
• W4281617196 title "The Achilles’ heel of cancer: targeting tumors via lysosome-induced immunogenic cell death" @default.
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