Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281620121> ?p ?o ?g. }
- W4281620121 endingPage "104396" @default.
- W4281620121 startingPage "104396" @default.
- W4281620121 abstract "Endothelial dysfunction, hallmarked by an imbalance between vasoconstriction and vasorelaxation, is associated with diabetes. Thioredoxin Interacting protein (TXNIP), controlled by an exquisitely glucose sensitive gene, is increasingly recognized for its role in diabetes. However, the role of TXNIP in modulating diabetes-related endothelial dysfunction remains unclear. To elucidate the role of TXNIP, we generated two novel mouse strains; endothelial-specific TXNIP knockout (EKO) and a Tet-O inducible, endothelial-specific TXNIP overexpression (EKI). Hyperglycemia was induced by streptozotocin (STZ) treatment in floxed control (fl/fl) and EKO mice. Doxycycline (DOX) was given to EKI mice to induce endothelial TXNIP overexpression. The ablation of endothelial TXNIP improved glucose tolerance in EKO mice. Acetylcholine-induced, endothelium-dependent vasorelaxation was impaired in STZ-treated fl/fl mice while this STZ impaired vasorelaxation was attenuated in EKO mice. Hyperglycemia induction of NLRP3 and reductions in Akt and eNOS phosphorylation were also mitigated in EKO mice. Overexpression of endothelial TXNIP did not impair glucose tolerance in DOX-treated EKI mice, however induction of endothelial TXNIP led to impaired vasorelaxation in EKI mice. This was associated with increased NLRP3 and reduced Akt and eNOS activation. In conclusion, deletion of endothelial TXNIP is protective against and overexpression of endothelial TXNIP induces endothelial dysfunction; thus, endothelial TXNIP plays a critical role in modulating endothelial dysfunction." @default.
- W4281620121 created "2022-06-13" @default.
- W4281620121 creator A5009121061 @default.
- W4281620121 creator A5020514266 @default.
- W4281620121 creator A5020670867 @default.
- W4281620121 creator A5031437217 @default.
- W4281620121 creator A5039670487 @default.
- W4281620121 creator A5066840342 @default.
- W4281620121 creator A5069501501 @default.
- W4281620121 creator A5076407569 @default.
- W4281620121 creator A5077924950 @default.
- W4281620121 date "2022-09-01" @default.
- W4281620121 modified "2023-10-13" @default.
- W4281620121 title "Endothelial thioredoxin interacting protein (TXNIP) modulates endothelium-dependent vasorelaxation in hyperglycemia" @default.
- W4281620121 cites W1489296222 @default.
- W4281620121 cites W1607892649 @default.
- W4281620121 cites W1678800844 @default.
- W4281620121 cites W1754624260 @default.
- W4281620121 cites W1892228010 @default.
- W4281620121 cites W1964240133 @default.
- W4281620121 cites W1968994105 @default.
- W4281620121 cites W1975707328 @default.
- W4281620121 cites W1979349833 @default.
- W4281620121 cites W1982267895 @default.
- W4281620121 cites W1988367094 @default.
- W4281620121 cites W2004170579 @default.
- W4281620121 cites W2033638350 @default.
- W4281620121 cites W2034998579 @default.
- W4281620121 cites W2052998740 @default.
- W4281620121 cites W2060446250 @default.
- W4281620121 cites W2061741332 @default.
- W4281620121 cites W2064413370 @default.
- W4281620121 cites W2081530424 @default.
- W4281620121 cites W2098563995 @default.
- W4281620121 cites W2111154780 @default.
- W4281620121 cites W2121621013 @default.
- W4281620121 cites W2125039061 @default.
- W4281620121 cites W2132403739 @default.
- W4281620121 cites W2136206042 @default.
- W4281620121 cites W2143127415 @default.
- W4281620121 cites W2150158709 @default.
- W4281620121 cites W2152156058 @default.
- W4281620121 cites W2158951820 @default.
- W4281620121 cites W2161200308 @default.
- W4281620121 cites W2170492101 @default.
- W4281620121 cites W2174970887 @default.
- W4281620121 cites W2286048432 @default.
- W4281620121 cites W2325119695 @default.
- W4281620121 cites W2542088718 @default.
- W4281620121 cites W2569107931 @default.
- W4281620121 cites W2724739445 @default.
- W4281620121 cites W2750877869 @default.
- W4281620121 cites W2782689334 @default.
- W4281620121 cites W2783939587 @default.
- W4281620121 cites W2889301977 @default.
- W4281620121 cites W2985204127 @default.
- W4281620121 cites W2998390922 @default.
- W4281620121 cites W3001686306 @default.
- W4281620121 cites W3082409406 @default.
- W4281620121 doi "https://doi.org/10.1016/j.mvr.2022.104396" @default.
- W4281620121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35644243" @default.
- W4281620121 hasPublicationYear "2022" @default.
- W4281620121 type Work @default.
- W4281620121 citedByCount "3" @default.
- W4281620121 countsByYear W42816201212022 @default.
- W4281620121 countsByYear W42816201212023 @default.
- W4281620121 crossrefType "journal-article" @default.
- W4281620121 hasAuthorship W4281620121A5009121061 @default.
- W4281620121 hasAuthorship W4281620121A5020514266 @default.
- W4281620121 hasAuthorship W4281620121A5020670867 @default.
- W4281620121 hasAuthorship W4281620121A5031437217 @default.
- W4281620121 hasAuthorship W4281620121A5039670487 @default.
- W4281620121 hasAuthorship W4281620121A5066840342 @default.
- W4281620121 hasAuthorship W4281620121A5069501501 @default.
- W4281620121 hasAuthorship W4281620121A5076407569 @default.
- W4281620121 hasAuthorship W4281620121A5077924950 @default.
- W4281620121 hasConcept C123012128 @default.
- W4281620121 hasConcept C126322002 @default.
- W4281620121 hasConcept C134018914 @default.
- W4281620121 hasConcept C202751555 @default.
- W4281620121 hasConcept C2776151105 @default.
- W4281620121 hasConcept C2776992346 @default.
- W4281620121 hasConcept C2777622882 @default.
- W4281620121 hasConcept C2778326061 @default.
- W4281620121 hasConcept C2779076967 @default.
- W4281620121 hasConcept C2780972559 @default.
- W4281620121 hasConcept C2908690268 @default.
- W4281620121 hasConcept C3623737 @default.
- W4281620121 hasConcept C519581460 @default.
- W4281620121 hasConcept C55493867 @default.
- W4281620121 hasConcept C71924100 @default.
- W4281620121 hasConcept C86803240 @default.
- W4281620121 hasConceptScore W4281620121C123012128 @default.
- W4281620121 hasConceptScore W4281620121C126322002 @default.
- W4281620121 hasConceptScore W4281620121C134018914 @default.
- W4281620121 hasConceptScore W4281620121C202751555 @default.
- W4281620121 hasConceptScore W4281620121C2776151105 @default.
- W4281620121 hasConceptScore W4281620121C2776992346 @default.