FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281622877> ?p ?o ?g. }

• W4281622877 endingPage "265" @default.
• W4281622877 startingPage "256" @default.
• W4281622877 abstract "Patients with human papillomavirus oropharyngeal cancer are highly curable but risk significant long-term toxic effects with standard therapy. This study investigated a de-escalation strategy of decreased adjuvant radiation therapy and chemotherapy after transoral robotic surgery, and reports on long-term functional and quality of life (QOL) outcomes.Eligible patients had a p16-positive oropharyngeal cancer and ≤10 pack-year smoking history and underwent surgery followed by treatment with either 30 Gy delivered in 1.5-Gy fractions twice per day over 2 weeks with weekly docetaxel (15 mg/m2) if they had intermediate pathologic risk factors or 36 Gy in 1.8-Gy fractions twice per day over 2 weeks with the same chemotherapy if they had extranodal extension. Toxic effects, swallow function, and QOL were measured longitudinally.Seventy-nine patients (89.9% male) were treated and eligible for toxic effect and functional evaluation. Dry mouth was the most common grade 1 toxic effect at 1 year (55.6%), 2 years (53.3%), and 3 years (49.2%). The cumulative rates of grade 2 toxic effects at 1, 2, and 3 years were 1.4%, 6.7%, and 6.8%, respectively. There were only 2 grade 3 toxic effects at ≥1 year, including a grade 3 fatigue at 2.5 years, and a grade 3 superficial soft tissue fibrosis at 4 years. There were no grade 4 to 5 toxic effects. No patients were percutaneous endoscopic gastrostomy-dependent. Swallow function improved by 12 months posttreatment. QOL improved over time by all measurement tools and most patients returned to baseline level of function and QOL.De-escalated adjuvant therapy for select patients with human papillomavirus oropharyngeal cancer resulted in low rates of long-term toxic effects, excellent swallow outcomes, and preservation of global and xerostomia-related QOL." @default.
• W4281622877 created "2022-06-13" @default.
• W4281622877 creator A5000432344 @default.
• W4281622877 creator A5008026182 @default.
• W4281622877 creator A5009221427 @default.
• W4281622877 creator A5013456637 @default.
• W4281622877 creator A5013768271 @default.
• W4281622877 creator A5016123395 @default.
• W4281622877 creator A5038981517 @default.
• W4281622877 creator A5043578442 @default.
• W4281622877 creator A5057236689 @default.
• W4281622877 creator A5076663691 @default.
• W4281622877 creator A5081947660 @default.
• W4281622877 creator A5083080294 @default.
• W4281622877 creator A5083170859 @default.
• W4281622877 creator A5089766682 @default.
• W4281622877 creator A5091532148 @default.
• W4281622877 date "2022-10-01" @default.
• W4281622877 modified "2023-10-02" @default.
• W4281622877 title "Long-Term Toxic Effects, Swallow Function, and Quality of Life on MC1273: A Phase 2 Study of Dose De-escalation for Adjuvant Chemoradiation in Human Papillomavirus-Positive Oropharyngeal Cancer" @default.
• W4281622877 cites W1564950817 @default.
• W4281622877 cites W1965967439 @default.
• W4281622877 cites W1967494799 @default.
• W4281622877 cites W2097877264 @default.
• W4281622877 cites W2100994230 @default.
• W4281622877 cites W2110664940 @default.
• W4281622877 cites W2118772763 @default.
• W4281622877 cites W2120068217 @default.
• W4281622877 cites W2136257552 @default.
• W4281622877 cites W2140753782 @default.
• W4281622877 cites W2145078756 @default.
• W4281622877 cites W2158534818 @default.
• W4281622877 cites W2159631730 @default.
• W4281622877 cites W2173072896 @default.
• W4281622877 cites W2473786944 @default.
• W4281622877 cites W2566106337 @default.
• W4281622877 cites W2605574960 @default.
• W4281622877 cites W2791976093 @default.
• W4281622877 cites W2899132665 @default.
• W4281622877 cites W2901263658 @default.
• W4281622877 cites W2910411436 @default.
• W4281622877 cites W2940897767 @default.
• W4281622877 cites W2948644893 @default.
• W4281622877 cites W2967453129 @default.
• W4281622877 cites W2968987551 @default.
• W4281622877 cites W3007505541 @default.
• W4281622877 cites W3116312181 @default.
• W4281622877 cites W3122345229 @default.
• W4281622877 cites W3181049803 @default.
• W4281622877 cites W3183211862 @default.
• W4281622877 doi "https://doi.org/10.1016/j.ijrobp.2022.05.047" @default.
• W4281622877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35675850" @default.
• W4281622877 hasPublicationYear "2022" @default.
• W4281622877 type Work @default.
• W4281622877 citedByCount "1" @default.
• W4281622877 countsByYear W42816228772023 @default.
• W4281622877 crossrefType "journal-article" @default.
• W4281622877 hasAuthorship W4281622877A5000432344 @default.
• W4281622877 hasAuthorship W4281622877A5008026182 @default.
• W4281622877 hasAuthorship W4281622877A5009221427 @default.
• W4281622877 hasAuthorship W4281622877A5013456637 @default.
• W4281622877 hasAuthorship W4281622877A5013768271 @default.
• W4281622877 hasAuthorship W4281622877A5016123395 @default.
• W4281622877 hasAuthorship W4281622877A5038981517 @default.
• W4281622877 hasAuthorship W4281622877A5043578442 @default.
• W4281622877 hasAuthorship W4281622877A5057236689 @default.
• W4281622877 hasAuthorship W4281622877A5076663691 @default.
• W4281622877 hasAuthorship W4281622877A5081947660 @default.
• W4281622877 hasAuthorship W4281622877A5083080294 @default.
• W4281622877 hasAuthorship W4281622877A5083170859 @default.
• W4281622877 hasAuthorship W4281622877A5089766682 @default.
• W4281622877 hasAuthorship W4281622877A5091532148 @default.
• W4281622877 hasBestOaLocation W42816228771 @default.
• W4281622877 hasConcept C10138342 @default.
• W4281622877 hasConcept C121608353 @default.
• W4281622877 hasConcept C126322002 @default.
• W4281622877 hasConcept C141071460 @default.
• W4281622877 hasConcept C143998085 @default.
• W4281622877 hasConcept C159110408 @default.
• W4281622877 hasConcept C162324750 @default.
• W4281622877 hasConcept C2776694085 @default.
• W4281622877 hasConcept C2779951463 @default.
• W4281622877 hasConcept C2780075904 @default.
• W4281622877 hasConcept C2781190966 @default.
• W4281622877 hasConcept C509974204 @default.
• W4281622877 hasConcept C54400483 @default.
• W4281622877 hasConcept C71924100 @default.
• W4281622877 hasConcept C90924648 @default.
• W4281622877 hasConceptScore W4281622877C10138342 @default.
• W4281622877 hasConceptScore W4281622877C121608353 @default.
• W4281622877 hasConceptScore W4281622877C126322002 @default.
• W4281622877 hasConceptScore W4281622877C141071460 @default.
• W4281622877 hasConceptScore W4281622877C143998085 @default.
• W4281622877 hasConceptScore W4281622877C159110408 @default.
• W4281622877 hasConceptScore W4281622877C162324750 @default.
• W4281622877 hasConceptScore W4281622877C2776694085 @default.
• W4281622877 hasConceptScore W4281622877C2779951463 @default.
• W4281622877 hasConceptScore W4281622877C2780075904 @default.

• next