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- W4281623109 abstract "Abstract CCAR2 (cell cycle and apoptosis regulator 2) is a multifaceted protein involved in cell survival and death following cytotoxic stress. However, little is known about the physiological functions of CCAR2 in regulating cell proliferation in the absence of external stimuli. The present study shows that CCAR2-deficient cells possess multilobulated nuclei, suggesting a defect in cell division. In particular, the duration of mitotic phase was perturbed. This disturbance of mitotic progression resulted from premature loss of cohesion with the centromere, and inactivation of the spindle assembly checkpoint during prometaphase and metaphase. It resulted in the formation of lagging chromosomes during anaphase, leading ultimately to the activation of the abscission checkpoint to halt cytokinesis. The CCAR2-dependent mitotic progression was related to spatiotemporal regulation of active Aurora B. In conclusion, the results suggest that CCAR2 governs mitotic events, including proper chromosome segregation and cytokinetic division, to maintain chromosomal stability." @default.
- W4281623109 created "2022-06-13" @default.
- W4281623109 creator A5032383727 @default.
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- W4281623109 date "2022-06-07" @default.
- W4281623109 modified "2023-10-13" @default.
- W4281623109 title "CCAR2 controls mitotic progression through spatiotemporal regulation of Aurora B" @default.
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- W4281623109 doi "https://doi.org/10.1038/s41419-022-04990-8" @default.
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