Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281625300> ?p ?o ?g. }
- W4281625300 endingPage "3607" @default.
- W4281625300 startingPage "3607" @default.
- W4281625300 abstract "Recent studies on the ethnomedicinal use of Clinacanthus nutans suggest promising anti-inflammatory, anti-tumorigenic, and antiviral properties for this plant. Extraction of the leaves with polar and nonpolar solvents has yielded many C-glycosyl flavones, including schaftoside, isoorientin, orientin, isovitexin, and vitexin. Aside from studies with different extracts, there is increasing interest to understand the properties of these components, especially regarding their ability to exert anti-inflammatory effects on cells and tissues. A major focus for this review is to obtain information on the effects of C. nutans extracts and its phytochemical components on inflammatory signaling pathways in the peripheral and central nervous system. Particular emphasis is placed on their role to target the Toll-like receptor 4 (TLR4)-NF-kB pathway and pro-inflammatory cytokines, the antioxidant defense pathway involving nuclear factor erythroid-2-related factor 2 (NRF2) and heme oxygenase 1 (HO-1); and the phospholipase A2 (PLA2) pathway linking to cyclooxygenase-2 (COX-2) and production of eicosanoids. The ability to provide a better understanding of the molecular targets and mechanism of action of C. nutans extracts and their phytochemical components should encourage future studies to develop new therapeutic strategies for better use of this herb to combat inflammatory diseases." @default.
- W4281625300 created "2022-06-13" @default.
- W4281625300 creator A5026453991 @default.
- W4281625300 creator A5038314607 @default.
- W4281625300 creator A5073539249 @default.
- W4281625300 creator A5087272338 @default.
- W4281625300 date "2022-06-04" @default.
- W4281625300 modified "2023-09-30" @default.
- W4281625300 title "Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans" @default.
- W4281625300 cites W1994068997 @default.
- W4281625300 cites W2009985025 @default.
- W4281625300 cites W2012940091 @default.
- W4281625300 cites W2019435413 @default.
- W4281625300 cites W2025107493 @default.
- W4281625300 cites W2037706036 @default.
- W4281625300 cites W2037956480 @default.
- W4281625300 cites W2041724483 @default.
- W4281625300 cites W2049592294 @default.
- W4281625300 cites W2059719734 @default.
- W4281625300 cites W2062070883 @default.
- W4281625300 cites W2066727978 @default.
- W4281625300 cites W2069780193 @default.
- W4281625300 cites W2074665675 @default.
- W4281625300 cites W2089435156 @default.
- W4281625300 cites W2089892512 @default.
- W4281625300 cites W2092550804 @default.
- W4281625300 cites W2124029073 @default.
- W4281625300 cites W2127691633 @default.
- W4281625300 cites W2149008455 @default.
- W4281625300 cites W2191092178 @default.
- W4281625300 cites W2220596386 @default.
- W4281625300 cites W2227739974 @default.
- W4281625300 cites W2292759380 @default.
- W4281625300 cites W2295469940 @default.
- W4281625300 cites W2301618061 @default.
- W4281625300 cites W2321539913 @default.
- W4281625300 cites W2322559033 @default.
- W4281625300 cites W2385582995 @default.
- W4281625300 cites W2427216351 @default.
- W4281625300 cites W2465302470 @default.
- W4281625300 cites W2523145916 @default.
- W4281625300 cites W2560552839 @default.
- W4281625300 cites W2571751736 @default.
- W4281625300 cites W2575031573 @default.
- W4281625300 cites W2575673057 @default.
- W4281625300 cites W2580853226 @default.
- W4281625300 cites W2593939781 @default.
- W4281625300 cites W2626437716 @default.
- W4281625300 cites W2714456978 @default.
- W4281625300 cites W2760232644 @default.
- W4281625300 cites W2760984022 @default.
- W4281625300 cites W2775074171 @default.
- W4281625300 cites W2790750729 @default.
- W4281625300 cites W2791608640 @default.
- W4281625300 cites W2792726946 @default.
- W4281625300 cites W2795019013 @default.
- W4281625300 cites W2801981220 @default.
- W4281625300 cites W2802534073 @default.
- W4281625300 cites W2809569263 @default.
- W4281625300 cites W2810666392 @default.
- W4281625300 cites W2810978876 @default.
- W4281625300 cites W2889523012 @default.
- W4281625300 cites W2890348188 @default.
- W4281625300 cites W2891120642 @default.
- W4281625300 cites W2891974508 @default.
- W4281625300 cites W2901211030 @default.
- W4281625300 cites W2901827844 @default.
- W4281625300 cites W2912437421 @default.
- W4281625300 cites W2922481826 @default.
- W4281625300 cites W2944645273 @default.
- W4281625300 cites W2947295525 @default.
- W4281625300 cites W2948191628 @default.
- W4281625300 cites W2953366625 @default.
- W4281625300 cites W2966086996 @default.
- W4281625300 cites W2980567543 @default.
- W4281625300 cites W2981767662 @default.
- W4281625300 cites W2983626068 @default.
- W4281625300 cites W2990599165 @default.
- W4281625300 cites W2998242518 @default.
- W4281625300 cites W3001785361 @default.
- W4281625300 cites W3006157746 @default.
- W4281625300 cites W3007847017 @default.
- W4281625300 cites W3012424094 @default.
- W4281625300 cites W3013580342 @default.
- W4281625300 cites W3022837017 @default.
- W4281625300 cites W3025505652 @default.
- W4281625300 cites W3033209762 @default.
- W4281625300 cites W3034822890 @default.
- W4281625300 cites W3036781013 @default.
- W4281625300 cites W3043773406 @default.
- W4281625300 cites W3044845649 @default.
- W4281625300 cites W3085390464 @default.
- W4281625300 cites W3092079018 @default.
- W4281625300 cites W3092164524 @default.
- W4281625300 cites W3094491552 @default.
- W4281625300 cites W3097319598 @default.
- W4281625300 cites W3104682346 @default.
- W4281625300 cites W3110258185 @default.