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• W4281635303 endingPage "105921" @default.
• W4281635303 startingPage "105921" @default.
• W4281635303 abstract "Fragment-based drug discovery, as a complementary method to traditional screening, has a broad momentum of development in academia, as well as large pharmaceutical companies and biotechnology laboratories. It is used to select favorable combinations of fragments or extend new drug molecules to obtain highly active drug candidates. The strategies used to develop active molecules from fragments are usually three approaches: growth, ligation and incorporation, where the ligation approach provides a theoretical opportunity for rapid access to binding energy. Here, we highlight linkers with different types and classifications that have been published in the past ten years, and explain how these linkers are designed and introduced into lead compounds to obtain potential candidate compounds." @default.
• W4281635303 created "2022-06-13" @default.
• W4281635303 creator A5008337415 @default.
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• W4281635303 creator A5031767581 @default.
• W4281635303 creator A5054889888 @default.
• W4281635303 creator A5056215148 @default.
• W4281635303 creator A5062731143 @default.
• W4281635303 creator A5078938461 @default.
• W4281635303 date "2022-10-01" @default.
• W4281635303 modified "2023-10-16" @default.
• W4281635303 title "Applications of “linkers” in fragment-based drug design" @default.
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