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• W4281636701 abstract "Outer hair cells are the cellular motors in the mammalian inner ear responsible for sensitive high-frequency hearing. Motor function over the frequency range of human hearing requires expression of the protein prestin in the OHC lateral membrane, which imparts piezoelectric properties to the cell membrane. In the present report, electrical power consumption and mechanical power output of the OHC membrane-motor complex are determined using previously published voltage-clamp data from isolated OHCs and membrane patches. Results reveal that power output peaks at a best frequency much higher than implied by the low-pass character of nonlinear capacitance, and much higher than the whole-cell resistive-capacitive corner frequency. High frequency power output is enabled by a -90° shift in the phase of electrical charge displacement in the membrane, manifested electrically as emergence of imaginary-valued nonlinear capacitance." @default.
• W4281636701 created "2022-06-13" @default.
• W4281636701 creator A5043264771 @default.
• W4281636701 date "2022-06-01" @default.
• W4281636701 modified "2023-10-17" @default.
• W4281636701 title "Analysis of outer hair cell electromechanics reveals power delivery at the upper-frequency limits of hearing" @default.
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• W4281636701 doi "https://doi.org/10.1098/rsif.2022.0139" @default.
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