Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281639891> ?p ?o ?g. }
- W4281639891 abstract "The blood-brain barrier (BBB) is a cellular and physical barrier with a crucial role in homeostasis of the brain extracellular environment. It controls the imports of nutrients to the brain and exports toxins and pathogens. Dysregulation of the blood-brain barrier increases permeability and contributes to pathologies, including Alzheimer's disease, epilepsy, and ischemia. It remains unclear how a dysregulated BBB contributes to these different syndromes. Initial studies on the role of the BBB in neurological disorders and also techniques to permit the entry of therapeutic molecules were made in animals. This review examines progress in the use of human models of the BBB, more relevant to human neurological disorders. In recent years, the functionality and complexity of in vitro BBB models have increased. Initial efforts consisted of static transwell cultures of brain endothelial cells. Human cell models based on microfluidics or organoids derived from human-derived induced pluripotent stem cells have become more realistic and perform better. We consider the architecture of different model generations as well as the cell types used in their fabrication. Finally, we discuss optimal models to study neurodegenerative diseases, brain glioma, epilepsies, transmigration of peripheral immune cells, and brain entry of neurotrophic viruses and metastatic cancer cells." @default.
- W4281639891 created "2022-06-13" @default.
- W4281639891 creator A5041216334 @default.
- W4281639891 creator A5075314368 @default.
- W4281639891 date "2022-06-10" @default.
- W4281639891 modified "2023-10-14" @default.
- W4281639891 title "Study of BBB Dysregulation in Neuropathogenicity Using Integrative Human Model of Blood–Brain Barrier" @default.
- W4281639891 cites W1536883565 @default.
- W4281639891 cites W1551217597 @default.
- W4281639891 cites W1571153387 @default.
- W4281639891 cites W15977723 @default.
- W4281639891 cites W1656832641 @default.
- W4281639891 cites W1964319708 @default.
- W4281639891 cites W1966720603 @default.
- W4281639891 cites W1968634197 @default.
- W4281639891 cites W1971125401 @default.
- W4281639891 cites W1973763077 @default.
- W4281639891 cites W1974291993 @default.
- W4281639891 cites W1976096075 @default.
- W4281639891 cites W1978041336 @default.
- W4281639891 cites W1980661152 @default.
- W4281639891 cites W1981880308 @default.
- W4281639891 cites W1987305063 @default.
- W4281639891 cites W1991436939 @default.
- W4281639891 cites W1999061307 @default.
- W4281639891 cites W1999631936 @default.
- W4281639891 cites W1999866221 @default.
- W4281639891 cites W2000055713 @default.
- W4281639891 cites W2001689820 @default.
- W4281639891 cites W2001726213 @default.
- W4281639891 cites W2004832585 @default.
- W4281639891 cites W2006035554 @default.
- W4281639891 cites W2008590928 @default.
- W4281639891 cites W2010256443 @default.
- W4281639891 cites W2010969043 @default.
- W4281639891 cites W2011180841 @default.
- W4281639891 cites W2012912989 @default.
- W4281639891 cites W2013305606 @default.
- W4281639891 cites W2015195193 @default.
- W4281639891 cites W2018286352 @default.
- W4281639891 cites W2019039716 @default.
- W4281639891 cites W2022120753 @default.
- W4281639891 cites W2024170393 @default.
- W4281639891 cites W2035833975 @default.
- W4281639891 cites W2039960457 @default.
- W4281639891 cites W2040046096 @default.
- W4281639891 cites W2041212534 @default.
- W4281639891 cites W2042883482 @default.
- W4281639891 cites W2042938829 @default.
- W4281639891 cites W2046895286 @default.
- W4281639891 cites W2047838688 @default.
- W4281639891 cites W2048329840 @default.
- W4281639891 cites W2051250723 @default.
- W4281639891 cites W2051923900 @default.
- W4281639891 cites W2054909845 @default.
- W4281639891 cites W2055467683 @default.
- W4281639891 cites W2059592009 @default.
- W4281639891 cites W2065682534 @default.
- W4281639891 cites W2070207411 @default.
- W4281639891 cites W2070257574 @default.
- W4281639891 cites W2073698777 @default.
- W4281639891 cites W2074850583 @default.
- W4281639891 cites W2075165836 @default.
- W4281639891 cites W2076513746 @default.
- W4281639891 cites W2077065233 @default.
- W4281639891 cites W2079177429 @default.
- W4281639891 cites W2080353159 @default.
- W4281639891 cites W2081135553 @default.
- W4281639891 cites W2081858473 @default.
- W4281639891 cites W2090458882 @default.
- W4281639891 cites W2091579582 @default.
- W4281639891 cites W2091680093 @default.
- W4281639891 cites W2100401597 @default.
- W4281639891 cites W2102653571 @default.
- W4281639891 cites W2105301861 @default.
- W4281639891 cites W2105412757 @default.
- W4281639891 cites W2107527993 @default.
- W4281639891 cites W2107798346 @default.
- W4281639891 cites W2109113634 @default.
- W4281639891 cites W2109644106 @default.
- W4281639891 cites W2111079150 @default.
- W4281639891 cites W2112937635 @default.
- W4281639891 cites W2114393924 @default.
- W4281639891 cites W2119329692 @default.
- W4281639891 cites W2119889685 @default.
- W4281639891 cites W2127568644 @default.
- W4281639891 cites W2135336711 @default.
- W4281639891 cites W2137352588 @default.
- W4281639891 cites W2138119512 @default.
- W4281639891 cites W2144750363 @default.
- W4281639891 cites W2145667182 @default.
- W4281639891 cites W2151961301 @default.
- W4281639891 cites W2154555351 @default.
- W4281639891 cites W2155436051 @default.
- W4281639891 cites W2161518657 @default.
- W4281639891 cites W2162020900 @default.
- W4281639891 cites W2162189519 @default.
- W4281639891 cites W2162611158 @default.
- W4281639891 cites W2164663536 @default.
- W4281639891 cites W2166046051 @default.