FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281640310> ?p ?o ?g. }

• W4281640310 abstract "The etiology and pathogenesis of granulomatous lobular mastitis (GLM) remain largely elusive and the expression levels and regulatory roles of microRNAs (miRNAs or miRs) in GLM have remained mostly undetermined. In the present study, the miRNAs that were differentially expressed in breast biopsy samples from patients with GLM and normal tissue adjacent to fibroadenoma were analyzed, a comprehensive differential expression profile of miRNAs was provided and potential biomarkers were screened out. The expression profile of miRNAs was determined by high-throughput sequencing in the tissues of patients with GLM and healthy controls. Significantly differentially expressed miRNAs were screened by threshold setting and cluster analysis and their target genes were analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. Finally, circulating differentially expressed miRNAs between the GLM and control groups were further analyzed by reverse transcription-quantitative PCR (RT-qPCR). A total of 31,077 miRNAs were detected by high-throughput sequencing. By using the cutoff criteria of |log2 fold change|>2.5 and q<0.001, 13 miRNAs that were indicated to be GLM biomarkers were screened out. The expression levels of these 13 miRNAs in the GLM group were higher than those in the control group. GO and KEGG enrichment analyses suggested that the occurrence and development of GLM may be associated with autoimmune inflammation, metabolism and pathogenic organisms. miR-451a and miR-5571-3p were confirmed to be significantly increased in the serum of patients with GLM compared with their levels in the serum of healthy volunteers, which suggests that they may be used as biomarkers of GLM. To the best of our knowledge, the present study was the first report detailing genome-wide miRNA profiling of patients with GLM compared with controls. The possible targets and pathways of GLM were evaluated by bioinformatics analysis. The present study identified 13 differentially expressed miRNAs with important theoretical significance and potential application. Furthermore, miR-451a and miR-5571-3p were verified by RT-qPCR as possible biomarkers of GLM." @default.
• W4281640310 created "2022-06-13" @default.
• W4281640310 creator A5012963048 @default.
• W4281640310 creator A5029470414 @default.
• W4281640310 creator A5030594393 @default.
• W4281640310 creator A5032982863 @default.
• W4281640310 creator A5033632697 @default.
• W4281640310 creator A5055265156 @default.
• W4281640310 creator A5067049042 @default.
• W4281640310 creator A5068914798 @default.
• W4281640310 creator A5087189975 @default.
• W4281640310 date "2022-06-08" @default.
• W4281640310 modified "2023-09-24" @default.
• W4281640310 title "Differential expression profiles of miRNA in granulomatous lobular mastitis and identification of possible biomarkers" @default.
• W4281640310 cites W1917673676 @default.
• W4281640310 cites W2042494445 @default.
• W4281640310 cites W2061922586 @default.
• W4281640310 cites W2096884048 @default.
• W4281640310 cites W2105106534 @default.
• W4281640310 cites W2114570899 @default.
• W4281640310 cites W2120456037 @default.
• W4281640310 cites W2123060905 @default.
• W4281640310 cites W2124827019 @default.
• W4281640310 cites W2130305733 @default.
• W4281640310 cites W2154085311 @default.
• W4281640310 cites W2537866854 @default.
• W4281640310 cites W2740967234 @default.
• W4281640310 cites W2789951619 @default.
• W4281640310 cites W2811212358 @default.
• W4281640310 cites W2899448598 @default.
• W4281640310 cites W2912022638 @default.
• W4281640310 cites W2952451833 @default.
• W4281640310 cites W2990197015 @default.
• W4281640310 cites W2998473806 @default.
• W4281640310 cites W3006098718 @default.
• W4281640310 cites W3038982714 @default.
• W4281640310 cites W3040523324 @default.
• W4281640310 cites W3087121724 @default.
• W4281640310 cites W3092453721 @default.
• W4281640310 cites W3093082724 @default.
• W4281640310 cites W3115455115 @default.
• W4281640310 cites W3123912131 @default.
• W4281640310 cites W3125790921 @default.
• W4281640310 cites W3127665045 @default.
• W4281640310 cites W3128329243 @default.
• W4281640310 cites W3132402507 @default.
• W4281640310 cites W3134616236 @default.
• W4281640310 cites W3152830133 @default.
• W4281640310 cites W3153653177 @default.
• W4281640310 cites W3154907363 @default.
• W4281640310 cites W3157158498 @default.
• W4281640310 cites W3161005629 @default.
• W4281640310 cites W3164861323 @default.
• W4281640310 cites W3170626555 @default.
• W4281640310 cites W3173576162 @default.
• W4281640310 cites W3176979814 @default.
• W4281640310 cites W3185924497 @default.
• W4281640310 cites W3190063836 @default.
• W4281640310 cites W3191093306 @default.
• W4281640310 cites W3194844456 @default.
• W4281640310 cites W3197288565 @default.
• W4281640310 cites W3209493634 @default.
• W4281640310 cites W3209907724 @default.
• W4281640310 doi "https://doi.org/10.3892/etm.2022.11427" @default.
• W4281640310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35837043" @default.
• W4281640310 hasPublicationYear "2022" @default.
• W4281640310 type Work @default.
• W4281640310 citedByCount "2" @default.
• W4281640310 countsByYear W42816403102022 @default.
• W4281640310 crossrefType "journal-article" @default.
• W4281640310 hasAuthorship W4281640310A5012963048 @default.
• W4281640310 hasAuthorship W4281640310A5029470414 @default.
• W4281640310 hasAuthorship W4281640310A5030594393 @default.
• W4281640310 hasAuthorship W4281640310A5032982863 @default.
• W4281640310 hasAuthorship W4281640310A5033632697 @default.
• W4281640310 hasAuthorship W4281640310A5055265156 @default.
• W4281640310 hasAuthorship W4281640310A5067049042 @default.
• W4281640310 hasAuthorship W4281640310A5068914798 @default.
• W4281640310 hasAuthorship W4281640310A5087189975 @default.
• W4281640310 hasBestOaLocation W42816403101 @default.
• W4281640310 hasConcept C104317684 @default.
• W4281640310 hasConcept C145059251 @default.
• W4281640310 hasConcept C150194340 @default.
• W4281640310 hasConcept C152724338 @default.
• W4281640310 hasConcept C162317418 @default.
• W4281640310 hasConcept C18431079 @default.
• W4281640310 hasConcept C2779018089 @default.
• W4281640310 hasConcept C2781018059 @default.
• W4281640310 hasConcept C29537977 @default.
• W4281640310 hasConcept C54355233 @default.
• W4281640310 hasConcept C70721500 @default.
• W4281640310 hasConcept C86803240 @default.
• W4281640310 hasConceptScore W4281640310C104317684 @default.
• W4281640310 hasConceptScore W4281640310C145059251 @default.
• W4281640310 hasConceptScore W4281640310C150194340 @default.
• W4281640310 hasConceptScore W4281640310C152724338 @default.
• W4281640310 hasConceptScore W4281640310C162317418 @default.
• W4281640310 hasConceptScore W4281640310C18431079 @default.
• W4281640310 hasConceptScore W4281640310C2779018089 @default.
• W4281640310 hasConceptScore W4281640310C2781018059 @default.

• next