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• W4281641818 endingPage "107588" @default.
• W4281641818 startingPage "107588" @default.
• W4281641818 abstract "Sepsis is the leading cause of death in intensive care unit (ICU), which is caused by deregulated immune responses to pathogens infection. Clinically, sepsis treatment is limited to antibiotics and supportive care, while there still lacks of specific molecular therapy. As a type of immune dysfunction disease, macrophages have been recognized as the key immune cells precipitating in the whole process of sepsis, which is activated into M1-like to trigger various inflammatory responses at early stage whereas polarized into M2-like to cause immunosuppression in later stage. Therefore, great attention has been paid on the design of nanomedicines to regulate the functions of macrophages for etiological treatment of sepsis, by virtue of the unique advantages of nano-drug delivery systems, such as enhanced drug bioavailability, targetability, reduced side-effects. This critical review aims to summarize the recent progress of macrophages-regulating nanoparticles for sepsis therapy. First, the essential roles of macrophages in the development and progression of sepsis have been introduced, including the positive roles of macrophages to combat infections and dysfunction of macrophages to cause body damages. We then focus our main attention to discuss the nanomedicines with different therapeutic mechanisms corresponding to each stage of sepsis, such as infection blockage, inflammation inhibition, immune functions recovery, as well as multifunctional nanomedicines. Finally, a few limitations of current nanomedicines are highlighted, and future perspective are speculated for potential clinical translation, which might pave the way for the development of macrophages-centered nanomedicines for more effective sepsis therapy." @default.
• W4281641818 created "2022-06-13" @default.
• W4281641818 creator A5000129068 @default.
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• W4281641818 creator A5062316201 @default.
• W4281641818 creator A5070812231 @default.
• W4281641818 creator A5087568911 @default.
• W4281641818 date "2023-03-01" @default.
• W4281641818 modified "2023-10-11" @default.
• W4281641818 title "Macrophages-regulating nanomedicines for sepsis therapy" @default.
• W4281641818 cites W1520263602 @default.
• W4281641818 cites W1573103899 @default.
• W4281641818 cites W1601040522 @default.
• W4281641818 cites W1858915087 @default.
• W4281641818 cites W1916893403 @default.
• W4281641818 cites W1966732899 @default.
• W4281641818 cites W1966945675 @default.
• W4281641818 cites W1967563064 @default.
• W4281641818 cites W1967980682 @default.
• W4281641818 cites W1976812054 @default.
• W4281641818 cites W1979309473 @default.
• W4281641818 cites W1980485314 @default.
• W4281641818 cites W1982795755 @default.
• W4281641818 cites W1988733171 @default.
• W4281641818 cites W1989090840 @default.
• W4281641818 cites W1992450378 @default.
• W4281641818 cites W1998427452 @default.
• W4281641818 cites W2002532523 @default.
• W4281641818 cites W2003776401 @default.
• W4281641818 cites W2005945320 @default.
• W4281641818 cites W2006028093 @default.
• W4281641818 cites W2008621673 @default.
• W4281641818 cites W2037541009 @default.
• W4281641818 cites W2039975172 @default.
• W4281641818 cites W2043253666 @default.
• W4281641818 cites W2049738744 @default.
• W4281641818 cites W2052748040 @default.
• W4281641818 cites W2055112613 @default.
• W4281641818 cites W2055411163 @default.
• W4281641818 cites W2060122053 @default.
• W4281641818 cites W2064741210 @default.
• W4281641818 cites W2066209509 @default.
• W4281641818 cites W2068417232 @default.
• W4281641818 cites W2081810806 @default.
• W4281641818 cites W2089503694 @default.
• W4281641818 cites W2091920893 @default.
• W4281641818 cites W2100820895 @default.
• W4281641818 cites W2105457815 @default.
• W4281641818 cites W2107928264 @default.
• W4281641818 cites W2120254551 @default.
• W4281641818 cites W2129081428 @default.
• W4281641818 cites W2133006561 @default.
• W4281641818 cites W2134928825 @default.
• W4281641818 cites W2135272175 @default.
• W4281641818 cites W2146185108 @default.
• W4281641818 cites W2147263332 @default.
• W4281641818 cites W2151311812 @default.
• W4281641818 cites W2156416784 @default.
• W4281641818 cites W2164481426 @default.
• W4281641818 cites W2197666871 @default.
• W4281641818 cites W2268822493 @default.
• W4281641818 cites W2269090499 @default.
• W4281641818 cites W2280404143 @default.
• W4281641818 cites W2298912458 @default.
• W4281641818 cites W2318544624 @default.
• W4281641818 cites W2332305257 @default.
• W4281641818 cites W2396063348 @default.
• W4281641818 cites W2531389434 @default.
• W4281641818 cites W2537589011 @default.
• W4281641818 cites W2553300030 @default.
• W4281641818 cites W2585406339 @default.
• W4281641818 cites W2590763650 @default.
• W4281641818 cites W2608823051 @default.
• W4281641818 cites W2611449600 @default.
• W4281641818 cites W2689318812 @default.
• W4281641818 cites W2724317418 @default.
• W4281641818 cites W2730923948 @default.
• W4281641818 cites W2737868829 @default.
• W4281641818 cites W2762411375 @default.
• W4281641818 cites W2765628451 @default.
• W4281641818 cites W2770395397 @default.
• W4281641818 cites W2774868879 @default.
• W4281641818 cites W2784412824 @default.
• W4281641818 cites W2788153396 @default.
• W4281641818 cites W2789337312 @default.
• W4281641818 cites W2793011605 @default.
• W4281641818 cites W2796142839 @default.
• W4281641818 cites W2803015713 @default.
• W4281641818 cites W2807377465 @default.
• W4281641818 cites W2807906301 @default.
• W4281641818 cites W2864267652 @default.
• W4281641818 cites W2883566781 @default.
• W4281641818 cites W2883666067 @default.
• W4281641818 cites W2886656280 @default.
• W4281641818 cites W2890167612 @default.
• W4281641818 cites W2893420719 @default.
• W4281641818 cites W2896767268 @default.
• W4281641818 cites W2896781864 @default.

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