FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281643522> ?p ?o ?g. }

• W4281643522 endingPage "4116" @default.
• W4281643522 startingPage "4108" @default.
• W4281643522 abstract "OX40 (CD134, TNFRSF4) is a member of the tumor necrosis factor receptor superfamily that can be activated by its cognate ligand OX40L (CD252, TNFSF4) and functions as a pair of T cell costimulatory molecules. The interaction between OX40 and OX40L (OX40/OX40L) plays a critical role in regulating antitumor immunity, including promoting effector T cells expansion and survival, blocking natural regulatory T cells (Treg) activity, and antagonizing inducible Treg generation. However, current OX40 agonists including anti-OX40 monoclonal antibodies (aOX40) have serious side effects after systemic administration, which limits their clinical success and application. Herein, we propose a strategy to reprogram tumor cells into OX40L-expressing “artificial” antigen-presenting cells (APCs) by OX40L plasmid-loaded nanoparticles for boosting antitumor immunity in situ. A novel gene transfection carrier was prepared by a modular hierarchical assembly method, which could efficiently transfect various tumor cells and express OX40L proteins on their surface. These surface-decorated OX40L proteins were proved to stimulate T cell proliferation in vitro while stimulating strong antitumor immune responses in vivo. Importantly, this in situ reprogramming strategy did not induce any toxicity as observed in aOX40 treatment, thus providing a novel method for immune checkpoint stimulator application." @default.
• W4281643522 created "2022-06-13" @default.
• W4281643522 creator A5008241939 @default.
• W4281643522 creator A5025674242 @default.
• W4281643522 creator A5036476234 @default.
• W4281643522 creator A5039803335 @default.
• W4281643522 creator A5045218766 @default.
• W4281643522 creator A5045930233 @default.
• W4281643522 creator A5046244179 @default.
• W4281643522 creator A5059247859 @default.
• W4281643522 creator A5064247618 @default.
• W4281643522 date "2022-06-02" @default.
• W4281643522 modified "2023-10-17" @default.
• W4281643522 title "In Situ Reprogramming of Tumors for Activating the OX40/OX40 Ligand Checkpoint Pathway and Boosting Antitumor Immunity" @default.
• W4281643522 cites W1673326613 @default.
• W4281643522 cites W1983679461 @default.
• W4281643522 cites W1995956587 @default.
• W4281643522 cites W2029855686 @default.
• W4281643522 cites W2035345231 @default.
• W4281643522 cites W2044835625 @default.
• W4281643522 cites W2065079114 @default.
• W4281643522 cites W2073727431 @default.
• W4281643522 cites W2078965027 @default.
• W4281643522 cites W2087757222 @default.
• W4281643522 cites W2089493370 @default.
• W4281643522 cites W2089551334 @default.
• W4281643522 cites W2118471749 @default.
• W4281643522 cites W2131950300 @default.
• W4281643522 cites W2140875987 @default.
• W4281643522 cites W2142219995 @default.
• W4281643522 cites W2145594744 @default.
• W4281643522 cites W2189381691 @default.
• W4281643522 cites W2807361338 @default.
• W4281643522 cites W2883467922 @default.
• W4281643522 cites W2912510115 @default.
• W4281643522 cites W2931089741 @default.
• W4281643522 cites W2952649651 @default.
• W4281643522 cites W2971814637 @default.
• W4281643522 cites W3032584645 @default.
• W4281643522 cites W3092185950 @default.
• W4281643522 cites W3111523765 @default.
• W4281643522 cites W3120676282 @default.
• W4281643522 cites W3158395889 @default.
• W4281643522 cites W3199259915 @default.
• W4281643522 cites W4206235192 @default.
• W4281643522 doi "https://doi.org/10.1021/acsbiomaterials.1c01637" @default.
• W4281643522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35653749" @default.
• W4281643522 hasPublicationYear "2022" @default.
• W4281643522 type Work @default.
• W4281643522 citedByCount "3" @default.
• W4281643522 countsByYear W42816435222023 @default.
• W4281643522 crossrefType "journal-article" @default.
• W4281643522 hasAuthorship W4281643522A5008241939 @default.
• W4281643522 hasAuthorship W4281643522A5025674242 @default.
• W4281643522 hasAuthorship W4281643522A5036476234 @default.
• W4281643522 hasAuthorship W4281643522A5039803335 @default.
• W4281643522 hasAuthorship W4281643522A5045218766 @default.
• W4281643522 hasAuthorship W4281643522A5045930233 @default.
• W4281643522 hasAuthorship W4281643522A5046244179 @default.
• W4281643522 hasAuthorship W4281643522A5059247859 @default.
• W4281643522 hasAuthorship W4281643522A5064247618 @default.
• W4281643522 hasConcept C1491633281 @default.
• W4281643522 hasConcept C193419808 @default.
• W4281643522 hasConcept C203014093 @default.
• W4281643522 hasConcept C2777701055 @default.
• W4281643522 hasConcept C2780674031 @default.
• W4281643522 hasConcept C502942594 @default.
• W4281643522 hasConcept C54355233 @default.
• W4281643522 hasConcept C77255625 @default.
• W4281643522 hasConcept C86803240 @default.
• W4281643522 hasConcept C8891405 @default.
• W4281643522 hasConcept C95444343 @default.
• W4281643522 hasConceptScore W4281643522C1491633281 @default.
• W4281643522 hasConceptScore W4281643522C193419808 @default.
• W4281643522 hasConceptScore W4281643522C203014093 @default.
• W4281643522 hasConceptScore W4281643522C2777701055 @default.
• W4281643522 hasConceptScore W4281643522C2780674031 @default.
• W4281643522 hasConceptScore W4281643522C502942594 @default.
• W4281643522 hasConceptScore W4281643522C54355233 @default.
• W4281643522 hasConceptScore W4281643522C77255625 @default.
• W4281643522 hasConceptScore W4281643522C86803240 @default.
• W4281643522 hasConceptScore W4281643522C8891405 @default.
• W4281643522 hasConceptScore W4281643522C95444343 @default.
• W4281643522 hasFunder F4320321001 @default.
• W4281643522 hasFunder F4320321133 @default.
• W4281643522 hasFunder F4320322847 @default.
• W4281643522 hasFunder F4320327282 @default.
• W4281643522 hasIssue "7" @default.
• W4281643522 hasLocation W42816435221 @default.
• W4281643522 hasLocation W42816435222 @default.
• W4281643522 hasOpenAccess W4281643522 @default.
• W4281643522 hasPrimaryLocation W42816435221 @default.
• W4281643522 hasRelatedWork W157270364 @default.
• W4281643522 hasRelatedWork W1994960978 @default.
• W4281643522 hasRelatedWork W202870370 @default.
• W4281643522 hasRelatedWork W2120365014 @default.
• W4281643522 hasRelatedWork W2164001237 @default.
• W4281643522 hasRelatedWork W2218274148 @default.

• next