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- W4281645196 abstract "Abstract Monoterpenoids are a large group of natural, speciality chemicals. Their global demand is surging and the use of engineered microbial hosts such as Escherichia coli is a compelling strategy to sustainably and economically produce these molecules at scale. However, most monoterpenoids are highly volatile, which presents unique challenges for their recovery. The use of biphasic fermentations employing a dodecane overlay for product capture has emerged as a popular solution to this problem. However, since the subsequent separation of the products from dodecane is exceptionally difficult, biphasic fermentations are not practical. To this end, we report the development of an extraction methodology employing a fluidized bed of an aliphatic methacrylate resin for ex situ recovery of carene that is produced by a genetically engineered strain of E. coli . The resin is suspended in water within a 3D‐printed reservoir and volatilized carene is continuously captured by sparging the gaseous outflow from the condenser of the fermenter through the reservoir. We observed that the adsorption of carene onto the resin follows the Freundlich equation and that the extraction efficiency was chiefly influenced by the rate of agitation of the fermentation broth, the volume of resin enclosed within the reservoir, and the airflow rate into the fermenter. We subsequently used a fractional factorial experimental design to identify optimal levels of each parameter and thereafter improved the extraction efficiency six‐fold over that of a dodecane overlay. Our work establishes strong foundations for the use of solid phase‐transfer separations for the continuous recovery of volatile fermentation products." @default.
- W4281645196 created "2022-06-13" @default.
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- W4281645196 date "2022-07-06" @default.
- W4281645196 modified "2023-09-27" @default.
- W4281645196 title "Continuous ex situ recovery of volatile monoterpenoids produced by genetically engineered <i>Escherichia coli</i>" @default.
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- W4281645196 doi "https://doi.org/10.1002/cjce.24486" @default.
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