Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281647564> ?p ?o ?g. }
- W4281647564 abstract "Sex differences in gene expression tend to increase with age across a variety of species, often coincident with the development of sexual dimorphism and maturational changes in hormone levels. However, because most transcriptome-wide characterizations of sexual divergence are framed as comparisons of sex-biased gene expression across ages, it can be difficult to determine the extent to which age-biased gene expression within each sex contributes to the emergence of sex-biased gene expression. Using RNAseq in the liver of the sexually dimorphic brown anole lizard (Anolis sagrei), we found that a pronounced increase in sex-biased gene expression with age was associated with a much greater degree of age-biased gene expression in males than in females. This pattern suggests that developmental changes in males, such as maturational increases in circulating testosterone, contribute disproportionately to the ontogenetic emergence of sex-biased gene expression. To test this hypothesis, we used four different experimental contrasts to independently characterize sets of genes whose expression differed as a function of castration and/or treatment with exogenous testosterone. We found that genes that were significantly male-biased in expression or upregulated as males matured tended to be upregulated by testosterone, whereas genes that were female-biased or downregulated as males matured tended to be downregulated by testosterone. Moreover, the first two principal components describing multivariate gene expression indicated that exogenous testosterone reversed many of the feminizing effects of castration on the liver transcriptome of maturing males. Collectively, our results suggest that developmental changes that occur in males contribute disproportionately to the emergence of sex-biased gene expression in the Anolis liver, and that many of these changes are orchestrated by androgens such as testosterone." @default.
- W4281647564 created "2022-06-13" @default.
- W4281647564 creator A5012281101 @default.
- W4281647564 creator A5032620293 @default.
- W4281647564 creator A5050241214 @default.
- W4281647564 creator A5064681789 @default.
- W4281647564 date "2022-06-02" @default.
- W4281647564 modified "2023-10-14" @default.
- W4281647564 title "Ontogenetic Change in Male Expression of Testosterone-Responsive Genes Contributes to the Emergence of Sex-Biased Gene Expression in Anolis sagrei" @default.
- W4281647564 cites W1964555623 @default.
- W4281647564 cites W1982685226 @default.
- W4281647564 cites W1991669878 @default.
- W4281647564 cites W1999752954 @default.
- W4281647564 cites W2033871860 @default.
- W4281647564 cites W2040131115 @default.
- W4281647564 cites W2040359453 @default.
- W4281647564 cites W2057277929 @default.
- W4281647564 cites W2058706806 @default.
- W4281647564 cites W2091532311 @default.
- W4281647564 cites W2099750470 @default.
- W4281647564 cites W2103441770 @default.
- W4281647564 cites W2108234281 @default.
- W4281647564 cites W2110065044 @default.
- W4281647564 cites W2114104545 @default.
- W4281647564 cites W2124774060 @default.
- W4281647564 cites W2129035631 @default.
- W4281647564 cites W2130116522 @default.
- W4281647564 cites W2133322228 @default.
- W4281647564 cites W2145416275 @default.
- W4281647564 cites W2153008405 @default.
- W4281647564 cites W2153320245 @default.
- W4281647564 cites W2158224437 @default.
- W4281647564 cites W2158389310 @default.
- W4281647564 cites W2159392878 @default.
- W4281647564 cites W2165244440 @default.
- W4281647564 cites W2169471192 @default.
- W4281647564 cites W2179438025 @default.
- W4281647564 cites W2243113002 @default.
- W4281647564 cites W2345338147 @default.
- W4281647564 cites W2466314544 @default.
- W4281647564 cites W2582676813 @default.
- W4281647564 cites W2640587371 @default.
- W4281647564 cites W2734694580 @default.
- W4281647564 cites W2792097129 @default.
- W4281647564 cites W2918086501 @default.
- W4281647564 cites W3080836913 @default.
- W4281647564 cites W3081158448 @default.
- W4281647564 cites W3099276507 @default.
- W4281647564 cites W3115831505 @default.
- W4281647564 cites W3169696467 @default.
- W4281647564 cites W3207510706 @default.
- W4281647564 cites W4205247356 @default.
- W4281647564 cites W4241872665 @default.
- W4281647564 doi "https://doi.org/10.3389/fphys.2022.886973" @default.
- W4281647564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35721538" @default.
- W4281647564 hasPublicationYear "2022" @default.
- W4281647564 type Work @default.
- W4281647564 citedByCount "0" @default.
- W4281647564 crossrefType "journal-article" @default.
- W4281647564 hasAuthorship W4281647564A5012281101 @default.
- W4281647564 hasAuthorship W4281647564A5032620293 @default.
- W4281647564 hasAuthorship W4281647564A5050241214 @default.
- W4281647564 hasAuthorship W4281647564A5064681789 @default.
- W4281647564 hasBestOaLocation W42816475641 @default.
- W4281647564 hasConcept C104317684 @default.
- W4281647564 hasConcept C105083479 @default.
- W4281647564 hasConcept C126322002 @default.
- W4281647564 hasConcept C134018914 @default.
- W4281647564 hasConcept C150194340 @default.
- W4281647564 hasConcept C162317418 @default.
- W4281647564 hasConcept C165864922 @default.
- W4281647564 hasConcept C2776948614 @default.
- W4281647564 hasConcept C2777871726 @default.
- W4281647564 hasConcept C2778945730 @default.
- W4281647564 hasConcept C2779279991 @default.
- W4281647564 hasConcept C54355233 @default.
- W4281647564 hasConcept C63405245 @default.
- W4281647564 hasConcept C71924100 @default.
- W4281647564 hasConcept C86803240 @default.
- W4281647564 hasConcept C90856448 @default.
- W4281647564 hasConceptScore W4281647564C104317684 @default.
- W4281647564 hasConceptScore W4281647564C105083479 @default.
- W4281647564 hasConceptScore W4281647564C126322002 @default.
- W4281647564 hasConceptScore W4281647564C134018914 @default.
- W4281647564 hasConceptScore W4281647564C150194340 @default.
- W4281647564 hasConceptScore W4281647564C162317418 @default.
- W4281647564 hasConceptScore W4281647564C165864922 @default.
- W4281647564 hasConceptScore W4281647564C2776948614 @default.
- W4281647564 hasConceptScore W4281647564C2777871726 @default.
- W4281647564 hasConceptScore W4281647564C2778945730 @default.
- W4281647564 hasConceptScore W4281647564C2779279991 @default.
- W4281647564 hasConceptScore W4281647564C54355233 @default.
- W4281647564 hasConceptScore W4281647564C63405245 @default.
- W4281647564 hasConceptScore W4281647564C71924100 @default.
- W4281647564 hasConceptScore W4281647564C86803240 @default.
- W4281647564 hasConceptScore W4281647564C90856448 @default.
- W4281647564 hasLocation W42816475641 @default.
- W4281647564 hasLocation W42816475642 @default.
- W4281647564 hasLocation W42816475643 @default.
- W4281647564 hasLocation W42816475644 @default.