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• W4281649983 abstract "Abstract Therapeutics to reduce intracranial pressure are an unmet need. Pre-clinical data has demonstrated a novel strategy to lower intracranial pressure using glucagon-like peptide-1 receptor signaling. Here, we translate these findings into patients by conducting a randomized, placebo controlled, double-blind trial to assess the effect of exenatide, a glucagon-like peptide-1 receptor agonist, on intracranial pressure in idiopathic intracranial hypertension. Telemetric intracranial pressure catheters enabled long-term intracranial pressure monitoring. The trial enrolled adult women with active idiopathic intracranial hypertension (intracranial pressure >25 cmCSF and papilloedema) who receive subcutaneous exenatide or placebo. The three primary outcome measures were intracranial pressure at 2.5 hours, 24 hours and 12 weeks and alpha set a priori at less than 0.1. Among the 16 women recruited, 15 completed the study (mean age 28 ± 9, body mass index 38.1 ± 6.2 kg/m 2 , intracranial pressure 30.6 ± 5.1 cmCSF). Exenatide significantly and meaningfully lowered intracranial pressure at 2.5 hours -5.7 ± 2.9 cmCSF ( p=0 . 048 ); 24 hours of -6.4 ± 2.9 cmCSF ( p=0 . 030 ); and 12 weeks -5.6 ± 3.0 cmCSF ( p=0 . 058 ). No serious safety signals were noted. This data provides confidence to proceed to a phase 3 trial in idiopathic intracranial hypertension and highlights the potential to utilise glucagon-like peptide-1 receptor agonist in other conditions characterised by raised intracranial pressure." @default.
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• W4281649983 date "2022-05-25" @default.
• W4281649983 modified "2023-10-18" @default.
• W4281649983 title "The effect of GLP-1RA exenatide on Idiopathic Intracranial Hypertension: Randomised Clinical Trial" @default.
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• W4281649983 doi "https://doi.org/10.1101/2022.05.24.22275518" @default.
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