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- W4281650459 abstract "The protein kinase, TANK-binding kinase 1 (TBK1), not only regulates various biological processes but also functions as an important regulator of human oncogenesis. However, the detailed function and molecular mechanisms of TBK1 in hepatocellular carcinoma (HCC), especially the resistance of HCC cells to molecular-targeted drugs, are almost unknown. In the present work, the role of TBK1 in regulating the sensitivity of HCC cells to molecular-targeted drugs was measured by multiple assays. The high expression of TBK1 was identified in HCC clinical specimens compared with paired non-tumor tissues. The high level of TBK1 in advanced HCC was associated with a poor prognosis in patients with advanced HCC who received the molecular-targeted drug, sorafenib, compared to patients with advanced HCC patients and a low level of TBK1. Overexpression of TBK1 in HCC cells induced their resistance to molecular-targeted drugs, whereas knockdown of TBK1 enhanced the cells' sensitivity to molecular-targeted dugs. Regarding the mechanism, although overexpression of TBK1 enhanced expression levels of drug-resistance and pro-survival-/anti-apoptosis-related factors, knockdown of TBK1 repressed the expression of these factors in HCC cells. Therefore, TBK1 is a promising therapeutic target for HCC treatment and knockdown of TBK1 enhanced sensitivity of HCC cells to molecular-targeted drugs." @default.
- W4281650459 created "2022-06-13" @default.
- W4281650459 creator A5010358646 @default.
- W4281650459 creator A5030513777 @default.
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- W4281650459 creator A5041058568 @default.
- W4281650459 creator A5051931642 @default.
- W4281650459 creator A5053958973 @default.
- W4281650459 creator A5071366009 @default.
- W4281650459 creator A5074134526 @default.
- W4281650459 creator A5090590010 @default.
- W4281650459 date "2022-06-07" @default.
- W4281650459 modified "2023-09-25" @default.
- W4281650459 title "Knockdown of TANK-Binding Kinase 1 Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Molecular-Targeted Drugs" @default.
- W4281650459 cites W1821077834 @default.
- W4281650459 cites W1971837077 @default.
- W4281650459 cites W1987275335 @default.
- W4281650459 cites W2025732964 @default.
- W4281650459 cites W2065147302 @default.
- W4281650459 cites W2088047746 @default.
- W4281650459 cites W2120687067 @default.
- W4281650459 cites W2340445357 @default.
- W4281650459 cites W2433482993 @default.
- W4281650459 cites W2530417471 @default.
- W4281650459 cites W2560499218 @default.
- W4281650459 cites W2598230851 @default.
- W4281650459 cites W2607409227 @default.
- W4281650459 cites W2748933803 @default.
- W4281650459 cites W2766561082 @default.
- W4281650459 cites W2770055960 @default.
- W4281650459 cites W2787358630 @default.
- W4281650459 cites W2801666689 @default.
- W4281650459 cites W2810034808 @default.
- W4281650459 cites W2883204623 @default.
- W4281650459 cites W2885746240 @default.
- W4281650459 cites W2909506514 @default.
- W4281650459 cites W2922159934 @default.
- W4281650459 cites W2971792960 @default.
- W4281650459 cites W2972619269 @default.
- W4281650459 cites W2975417827 @default.
- W4281650459 cites W2980590270 @default.
- W4281650459 cites W2988833568 @default.
- W4281650459 cites W2995463243 @default.
- W4281650459 cites W2999483628 @default.
- W4281650459 cites W3003360914 @default.
- W4281650459 cites W3004946110 @default.
- W4281650459 cites W3007378086 @default.
- W4281650459 cites W3011857315 @default.
- W4281650459 cites W3033849938 @default.
- W4281650459 cites W3035408975 @default.
- W4281650459 cites W3036988856 @default.
- W4281650459 cites W3041561265 @default.
- W4281650459 cites W3042880579 @default.
- W4281650459 cites W3083439167 @default.
- W4281650459 cites W3087595284 @default.
- W4281650459 cites W3088016495 @default.
- W4281650459 cites W3089866294 @default.
- W4281650459 cites W3113609895 @default.
- W4281650459 cites W3114083559 @default.
- W4281650459 cites W3114608781 @default.
- W4281650459 cites W3117083078 @default.
- W4281650459 cites W3118970349 @default.
- W4281650459 cites W3119009131 @default.
- W4281650459 cites W3123318267 @default.
- W4281650459 cites W3123446037 @default.
- W4281650459 cites W3125511383 @default.
- W4281650459 cites W3128124722 @default.
- W4281650459 cites W3128646645 @default.
- W4281650459 cites W3129501916 @default.
- W4281650459 cites W3129676671 @default.
- W4281650459 cites W3130142296 @default.
- W4281650459 cites W3154897461 @default.
- W4281650459 cites W3156693036 @default.
- W4281650459 cites W3157215406 @default.
- W4281650459 cites W3157452721 @default.
- W4281650459 cites W3162603402 @default.
- W4281650459 cites W3162819955 @default.
- W4281650459 cites W3163655456 @default.
- W4281650459 cites W3164109642 @default.
- W4281650459 cites W3164356564 @default.
- W4281650459 cites W3166816485 @default.
- W4281650459 cites W3169164434 @default.
- W4281650459 cites W3169335588 @default.
- W4281650459 cites W3169574128 @default.
- W4281650459 cites W3174900949 @default.
- W4281650459 cites W3178764027 @default.
- W4281650459 cites W3183181264 @default.
- W4281650459 cites W3185426724 @default.
- W4281650459 cites W3189406047 @default.
- W4281650459 cites W3189821569 @default.
- W4281650459 cites W3190205340 @default.
- W4281650459 cites W3196460117 @default.
- W4281650459 cites W3197184132 @default.
- W4281650459 cites W3205776856 @default.
- W4281650459 cites W3214600690 @default.
- W4281650459 cites W3214766808 @default.
- W4281650459 cites W4200017702 @default.
- W4281650459 cites W4200405832 @default.
- W4281650459 cites W4200451060 @default.
- W4281650459 cites W4212775035 @default.